Conformational selection in G-proteins: lessons from Ras and Rho.
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Principles and Overview of Sampling Methods for Modeling Macromolecular Structure and DynamicsExploring the role of receptor flexibility in structure-based drug discoveryConformational analysis of Clostridium difficile toxin B and its implications for substrate recognitionMechanism of Displacement of a Catalytically Essential Loop from the Active Site of Mammalian Fructose-1,6-bisphosphataseYeast translation elongation factor-1A binds vacuole-localized Rho1p to facilitate membrane integrity through F-actin remodeling.Identification of potential small molecule binding pockets on Rho family GTPasesDNA Polymerase Conformational Dynamics and the Role of Fidelity-Conferring Residues: Insights from Computational SimulationsKinesin-5 allosteric inhibitors uncouple the dynamics of nucleotide, microtubule, and neck-linker binding sites.H-Ras forms dimers on membrane surfaces via a protein-protein interface.Intrinsic K-Ras dynamics: A novel molecular dynamics data analysis method shows causality between residue pair motionsIn silico elucidation of the recognition dynamics of ubiquitinBoth protein dynamics and ligand concentration can shift the binding mechanism between conformational selection and induced fitThe role of conserved waters in conformational transitions of Q61H K-ras.Binding hotspots on K-ras: consensus ligand binding sites and other reactive regions from probe-based molecular dynamics analysis.Revealing conformational substates of lipidated N-Ras protein by pressure modulation.Overview of simulation studies on the enzymatic activity and conformational dynamics of the GTPase Ras.Accounting for receptor flexibility and enhanced sampling methods in computer-aided drug design.Specific Conformational States of Ras GTPase upon Effector Bindingw-REXAMD: A Hamiltonian Replica Exchange Approach to Improve Free Energy Calculations for Systems with Kinetically Trapped ConformationsOncogenic K-Ras Binds to an Anionic Membrane in Two Distinct Orientations: A Molecular Dynamics Analysis.Mapping the structural and dynamical features of kinesin motor domainsLessons from computer simulations of Ras proteins in solution and in membraneThe efficacy of Raf kinase recruitment to the GTPase H-ras depends on H-ras membrane conformer-specific nanoclustering.Nucleotide Dependent Switching in Rho GTPase: Conformational Heterogeneity and Competing Molecular Interactions.Flexible receptor docking for drug discovery.Membrane orientation dynamics of lipid-modified small GTPases.Disruption of intrinsic motions as a mechanism for enzyme inhibition.Discovery of Rab1 binding sites using an ensemble of clustering methods.Domain-opening and dynamic coupling in the α-subunit of heterotrimeric G proteins.Free energy simulations of a GTPase: GTP and GDP binding to archaeal initiation factor 2.Biosynthesis of a Novel Glutamate Racemase Containing a Site-Specific 7-Hydroxycoumarin Amino Acid: Enzyme-Ligand Promiscuity Revealed at the Atomistic Level.Light on the structural communication in Ras GTPases.Simulating GTP:Mg and GDP:Mg with a simple force field: a structural and thermodynamic analysis.Investigations of Takeout proteins' ligand binding and release mechanism using molecular dynamics simulation.Nucleotide recognition by the initiation factor aIF5B: Free energy simulations of a neoclassical GTPaseConformational selection through electrostatics: Free energy simulations of gtp and gdp binding to archaeal initiation factor 2
P2860
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P2860
Conformational selection in G-proteins: lessons from Ras and Rho.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Conformational selection in G-proteins: lessons from Ras and Rho.
@en
Conformational selection in G-proteins: lessons from Ras and Rho.
@nl
type
label
Conformational selection in G-proteins: lessons from Ras and Rho.
@en
Conformational selection in G-proteins: lessons from Ras and Rho.
@nl
prefLabel
Conformational selection in G-proteins: lessons from Ras and Rho.
@en
Conformational selection in G-proteins: lessons from Ras and Rho.
@nl
P2860
P1433
P1476
Conformational selection in G-proteins: lessons from Ras and Rho.
@en
P2093
Alemayehu A Gorfe
P2860
P356
10.1016/J.BPJ.2010.10.020
P407
P577
2010-12-01T00:00:00Z