Mechanism of phospho-ubiquitin-induced PARKIN activation.
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Ubiquitin modificationsMyosins, Actin and AutophagyImpaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron DegenerationUbiquitin phosphorylation in Parkinson's disease: Implications for pathogenesis and treatmentParkin Regulation and Neurodegenerative DisordersThe Function of Autophagy in Neurodegenerative DiseasesExpanding the ubiquitin code through post-translational modificationThe critical roles of mitophagy in cerebral ischemiaMolecular basis for specificity of the Met1-linked polyubiquitin signalTargeting Pink1-Parkin-mediated mitophagy for treating liver injuryGDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson diseaseProbes of ubiquitin E3 ligases enable systematic dissection of parkin activationStructural insights into Parkin substrate lysine targeting from minimal Miro substratesSite-specific Interaction Mapping of Phosphorylated Ubiquitin to Uncover Parkin Activation.Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation.Data in support of UbSRD: The Ubiquitin Structural Relational Database.A Ubl/ubiquitin switch in the activation of ParkinInteraction between RING1 (R1) and the Ubiquitin-like (UBL) Domains Is Critical for the Regulation of Parkin Activity.The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradationMethyl-Arginine Profile of Brain from Aged PINK1-KO+A53T-SNCA Mice Suggests Altered Mitochondrial Biogenesis.Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis.Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation.Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice.Covalent ISG15 conjugation positively regulates the ubiquitin E3 ligase activity of parkinPINK1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy.Structure of phosphorylated UBL domain and insights into PINK1-orchestrated parkin activation.PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology?Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism.Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI.Parkin-dependent mitophagy in the heart.Design Principles Involving Protein Disorder Facilitate Specific Substrate Selection and Degradation by the Ubiquitin-Proteasome System.Ubiquitin S65 phosphorylation engenders a pH-sensitive conformational switch.Specificity and disease in the ubiquitin systemCentral Parkin: The evolving role of Parkin in the heart.Parkin Regulates the Activity of Pyruvate Kinase M2Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.The increasing complexity of the ubiquitin code.The mitochondrial kinase PINK1: functions beyond mitophagy.Structural insights into the catalysis and regulation of E3 ubiquitin ligases.Autophagy in leukocytes and other cells: mechanisms, subsystem organization, selectivity, and links to innate immunity.
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P2860
Mechanism of phospho-ubiquitin-induced PARKIN activation.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Mechanism of phospho-ubiquitin-induced PARKIN activation.
@en
Mechanism of phospho-ubiquitin-induced PARKIN activation.
@nl
type
label
Mechanism of phospho-ubiquitin-induced PARKIN activation.
@en
Mechanism of phospho-ubiquitin-induced PARKIN activation.
@nl
prefLabel
Mechanism of phospho-ubiquitin-induced PARKIN activation.
@en
Mechanism of phospho-ubiquitin-induced PARKIN activation.
@nl
P2093
P2860
P356
P1433
P1476
Mechanism of phospho-ubiquitin-induced PARKIN activation.
@en
P2093
Alexander Schubert
David Komander
Michal Simicek
Tobias Wauer
P2860
P2888
P304
P356
10.1038/NATURE14879
P407
P577
2015-07-10T00:00:00Z
P6179
1019279072