about
Target engagement in lead generationAnalgesic and anti-inflammatory properties of novel, selective, and potent EP4 receptor antagonists.Recent progress in the development of selective TRPV1 antagonists for pain.How hydrogen bonds impact P-glycoprotein transport and permeability.Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression.Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache.Cyclic peptide natural products chart the frontier of oral bioavailability in the pursuit of undruggable targets.Stereochemistry Balances Cell Permeability and Solubility in the Naturally Derived Phepropeptin Cyclic Peptides.Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like ActNeuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid)A Receptor.Breakthroughs in neuroactive steroid drug discovery.Discovery of potent aryl-substituted 3-[(3-methylpyridine-2-carbonyl) amino]-2,4-dimethyl-benzoic acid EP4 antagonists with improved pharmacokinetic profile.Identification and biological activity of 6-alkyl-substituted 3-methyl-pyridine-2-carbonyl amino dimethyl-benzoic acid EP4 antagonists.Lipophilic Permeability Efficiency (LPE) reconciles the opposing roles of lipophilicity in membrane permeability and aqueous solubilityDiscovery of substituted-2,4-dimethyl-(naphthalene-4-carbonyl)amino-benzoic acid as potent and selective EP4 antagonistsDiscovery of selective N-[3-(1-methyl-piperidine-4-carbonyl)-phenyl]-benzamide-based 5-HT1F receptor agonists: Evolution from bicyclic to monocyclic coresTRP channels as emerging targets for pain therapeuticsDesign and syntheses of three haptens to generate catalytic antibodies that cleave amide bonds with nucleophilic catalysisStereoselective Reactions ofN-(9-Phenylfluoren-9-yl)-4-oxoproline Enolates. An Expedient Route for the Preparation of Conformationally Restricted Amino Acid AnaloguesEnantiospecific and Stereoselective Synthesis of Polyhydroxylated Pyrrolidines and Indolizidines fromtrans-4-Hydroxy-l-prolineWomen in Medicinal Chemistry Special IssueNew Chemical Modalities and Strategic Thinking in Early Drug DiscoveryMentoring Matters in Drug DiscoveryAllosteric Modalities for Membrane-Bound Receptors: Insights from Drug Hunting for Brain DiseasesBuilding upon Nature's Framework: Overview of Key Strategies Toward Increasing Drug-Like Properties of Natural Product Cyclopeptides and MacrocyclesWomen in Medicinal Chemistry Special Issue
P50
Q26827296-995AFD7A-C4C6-4392-9514-75164E88835DQ33777968-F32891A4-600C-443A-AA7C-5009FACC6BD7Q37320551-C7188BB6-878E-4A72-A370-A99D4E9CED6CQ38046015-41F0CFC7-10B0-4BD6-8ADD-C77B63DA36E0Q38731703-F51E1486-4229-41E8-80A4-B6B7A47C8B4AQ39138297-C972AFD8-5C7C-4C80-AF75-164C581C8A74Q39344144-A9F8149A-DCA1-47B0-8AF9-F2F9D3B2A72FQ42358786-AD695BDA-EB1B-4DB1-808B-5D53AB3F4915Q46954842-B00736E9-1619-4CCE-AC5E-6767CF4CA239Q47269228-69B7FE92-9F3F-4006-A394-45A4465EFFCFQ49977296-28016CBE-80F8-432C-8375-07F94C9A16F0Q53213684-0A1631D2-7A2C-491B-9836-41FA38D3CA1DQ53622852-3DB89CAA-A2B7-4555-B944-BB98942647ECQ58610950-A40CB7F0-19A7-451C-9136-0D2A548EF7C3Q62782943-B511EE5C-0656-4244-8C96-36AF81E86481Q62782971-F7722AAD-8330-4A11-9296-18331B0B50C2Q62783003-85C390C4-0EE5-485B-86DB-DFDA508F4BA7Q62783045-34C5811F-12EC-4617-B269-41F21E92079BQ62783058-063A8CC5-7849-40A0-8523-846A38F1183BQ62783081-6B3DACFC-6A28-4B84-B99F-F20B1BFCF95EQ90412575-40FBB9EE-A6BA-47D3-AAFE-C2242058961DQ90412597-1E6A3D6A-E2E7-4C05-8DB5-3E43CDFA5591Q90412616-4D29A6B8-1459-4A7C-AD7E-C3CD88E2C80AQ91350857-5CF0D56A-82A8-4EA6-A7AA-668C5FC34C46Q92330588-4736EFAE-B12C-46DB-9DB4-E86D621EACF1Q92929397-6F2A2BAD-C65E-48B2-A580-F2124AAE1E99
P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Maria-Jesus Blanco
@ast
Maria-Jesus Blanco
@en
Maria-Jesus Blanco
@es
Maria-Jesus Blanco
@nl
Maria-Jesus Blanco
@sl
type
label
Maria-Jesus Blanco
@ast
Maria-Jesus Blanco
@en
Maria-Jesus Blanco
@es
Maria-Jesus Blanco
@nl
Maria-Jesus Blanco
@sl
prefLabel
Maria-Jesus Blanco
@ast
Maria-Jesus Blanco
@en
Maria-Jesus Blanco
@es
Maria-Jesus Blanco
@nl
Maria-Jesus Blanco
@sl
P1053
E-4313-2017
P106
P1153
36850376600
P1960
YIn2-RUAAAAJ
P2038
Maria_Jesus_Blanco
P21
P31
P3829
P3835
maria-jesus-blanco2
P496
0000-0003-4333-365X