The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M β-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation

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Clinical Variants of New Delhi Metallo-β-Lactamase Are Evolving To Overcome Zinc Scarcity.Structural and Mechanistic Basis for Extended-Spectrum Drug-Resistance Mutations in Altering the Specificity of TEM, CTX-M, and KPC β-lactamases.Megahertz serial crystallography

P2860

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P2860

The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M β-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation

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2017 nî lūn-bûn

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2017年の論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年论文

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2017年论文

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2017年论文

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name

The Drug-Resistant Variant P16 ...... the Active Site upon Acylation

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The Drug-Resistant Variant P16 ...... the Active Site upon Acylation

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The Drug-Resistant Variant P16 ...... the Active Site upon Acylation

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The Drug-Resistant Variant P16 ...... the Active Site upon Acylation

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The Drug-Resistant Variant P16 ...... the Active Site upon Acylation

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The Drug-Resistant Variant P16 ...... the Active Site upon Acylation

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P1476

The Drug-Resistant Variant P16 ...... the Active Site upon Acylation

@en

P2093

Banumathi Sankaran

http://www.w3.org/2001/XMLSchema#string

Liya Hu

http://www.w3.org/2001/XMLSchema#string

Meha P Patel

http://www.w3.org/2001/XMLSchema#string

Vlatko Stojanoski

http://www.w3.org/2001/XMLSchema#string

P2860

Three decades of beta-lactamase inhibitors

Structures of the acyl-enzyme complexes of the Staphylococcus aureus beta-lactamase mutant Glu166Asp:Asn170Gln with benzylpenicillin and cephaloridine

Structures of ceftazidime and its transition-state analogue in complex with AmpC beta-lactamase: implications for resistance mutations and inhibitor design

Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs

Acyl-intermediate structures of the extended-spectrum class A beta-lactamase, Toho-1, in complex with cefotaxime, cephalothin, and benzylpenicillin

Molecular structure of the acyl-enzyme intermediate in beta-lactam hydrolysis at 1.7 A resolution

Genetic and Structural Characterization of an L201P Global Suppressor Substitution in TEM-1 β-Lactamase

Structural Bases for Stability–Function Tradeoffs in Antibiotic Resistance

Structural insights into substrate recognition and product expulsion in CTX-M enzymes

Crystal structure of the E166A mutant of extended-spectrum beta-lactamase Toho-1 at 1.8 A resolution

P304

3443-3453

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scholarly article

P356

10.1021/ACS.BIOCHEM.7B00176

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English

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P478

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B.V.Venkataram Prasad

Timothy Palzkill

P577

2017-06-14T00:00:00Z

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28613873

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P932

5645026

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The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M β-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation

about

P2860

P2860

The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M β-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation

description

name

type

label

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P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P932