SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins.
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Revealing Atomic-Level Mechanisms of Protein Allostery with Molecular Dynamics SimulationsExtended Phase-Space Methods for Enhanced Sampling in Molecular Simulations: A ReviewThematic Minireview Series: New Directions in G Protein-coupled Receptor PharmacologyComputational Simulation of the Activation Cycle of Gα Subunit in the G Protein Cycle Using an Elastic Network ModelThe Quantum Nature of Drug-Receptor Interactions: Deuteration Changes Binding Affinities for Histamine Receptor LigandsA Conserved Hydrophobic Core in Gαi1 Regulates G Protein Activation and Release from Activated ReceptorBeyond Membrane Protein Structure: Drug Discovery, Dynamics and Difficulties.Role of Structural Dynamics at the Receptor G Protein Interface for Signal TransductionOptimization of a Nucleic Acids united-RESidue 2-Point model (NARES-2P) with a maximum-likelihood approachDynamic Coupling and Allosteric Networks in the α Subunit of Heterotrimeric G Proteins.Probing Gαi1 protein activation at single-amino acid resolution.Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding.Diverse activation pathways in class A GPCRs converge near the G-protein-coupling regionThe structural basis of the dominant negative phenotype of the Gαi1β1γ2 G203A/A326S heterotrimer.GIV/Girdin activates Gαi and inhibits Gαs via the same motifRic-8A, a G protein chaperone with nucleotide exchange activity induces long-range secondary structure changes in Gα.Recent Progress in Understanding the Conformational Mechanism of Heterotrimeric G Protein ActivationDIRECT-ID: An automated method to identify and quantify conformational variations--application to β2 -adrenergic GPCR.The ins and outs of adrenergic signaling.Computational Membrane Biophysics: From Ion Channels Interactions with Drugs to Cellular Function.Homology modeling of FFA2 identifies novel agonists that potentiate insulin secretion.Single-molecule analysis of ligand efficacy in β2AR-G-protein activation.Invited review: Activation of G proteins by GTP and the mechanism of Gα-catalyzed GTP hydrolysis.Hitchhiking on the heptahelical highway: structure and function of 7TM receptor complexes.Mechanistic insights into GPCR-G protein interactions.The GAPs, GEFs, GDIs and…now, GEMs: New kids on the heterotrimeric G protein signaling block.Capturing Invisible Motions in the Transition from Ground to Rare Excited States of T4 Lysozyme L99A.A PII-Like Protein Regulated by Bicarbonate: Structural and Biochemical Studies of the Carboxysome-Associated CPII Protein.Engineering a minimal G protein to facilitate crystallisation of G protein-coupled receptors in their active conformation.A test on reactive force fields for the study of silica dimerization reactions.Nanosecond Dynamics of Gαi1 Bound to Nucleotides or Ric-8A, a Gα Chaperone with GEF Activity.Biased AllosteryER/K linked GPCR-G protein fusions systematically modulate second messenger response in cellsExpression and Purification of the Pain Receptor TRPV1 for Spectroscopic AnalysisLipid interaction sites on channels, transporters and receptors: Recent insights from molecular dynamics simulations.Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif.Exploring the inhibition mechanism of adenylyl cyclase type 5 by n-terminal myristoylated Gαi1Single-molecule imaging reveals receptor-G protein interactions at cell surface hot spots.Intracellular Transfer of Na+ in an Active-State G-Protein-Coupled Receptor.Finding the needle in the haystack: towards solving the protein-folding problem computationally.
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P2860
SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
SIGNAL TRANSDUCTION. Structura ...... in heterotrimeric G proteins.
@en
SIGNAL TRANSDUCTION. Structura ...... in heterotrimeric G proteins.
@nl
type
label
SIGNAL TRANSDUCTION. Structura ...... in heterotrimeric G proteins.
@en
SIGNAL TRANSDUCTION. Structura ...... in heterotrimeric G proteins.
@nl
prefLabel
SIGNAL TRANSDUCTION. Structura ...... in heterotrimeric G proteins.
@en
SIGNAL TRANSDUCTION. Structura ...... in heterotrimeric G proteins.
@nl
P2093
P2860
P50
P356
P1433
P1476
SIGNAL TRANSDUCTION. Structura ...... in heterotrimeric G proteins.
@en
P2093
Ansgar Philippsen
Daniel H Arlow
Daniel Hilger
David E Shaw
Michael T Lerch
Nicolas Villanueva
Roger K Sunahara
Ron O Dror
Thomas J Mildorf
Zhongyu Yang
P2860
P304
P356
10.1126/SCIENCE.AAA5264
P407
P577
2015-06-01T00:00:00Z