Comparative analysis of Drosophila and mammalian complexins as fusion clamps and facilitators of neurotransmitter release.
about
Deconstructing complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypesC-terminal complexin sequence is selectively required for clamping and priming but not for Ca2+ triggering of synaptic exocytosisComplexin activates exocytosis of distinct secretory vesicles controlled by different synaptotagminsComplexins: small but capableComplexin cross-links prefusion SNAREs into a zigzag arrayComplexin controls spontaneous and evoked neurotransmitter release by regulating the timing and properties of synaptotagmin activitySynaptic vesicles position complexin to block spontaneous fusionComplexin maintains vesicles in the primed state in C. elegansComplexin has opposite effects on two modes of synaptic vesicle fusionMolecular machines in the synapse: overlapping protein sets control distinct steps in neurosecretionRe-examining how complexin inhibits neurotransmitter release.Evolutionary Divergence of the C-terminal Domain of Complexin Accounts for Functional Disparities between Vertebrate and Invertebrate ComplexinsGenetic analysis of the Complexin trans-clamping model for cross-linking SNARE complexes in vivoTensor-based morphometry and stereology reveal brain pathology in the complexin1 knockout mouseMembrane curvature sensing by the C-terminal domain of complexin.Calcium sensitive ring-like oligomers formed by synaptotagminWolf-Hirschhorn syndrome: A review and update.The accessory helix of complexin functions by stabilizing central helix secondary structureTransmission, Development, and Plasticity of Synapses.Differential regulation of evoked and spontaneous neurotransmitter release by C-terminal modifications of complexinEvolutionary conservation of complexins: from choanoflagellates to mice.Phosphorylation of Complexin by PKA Regulates Activity-Dependent Spontaneous Neurotransmitter Release and Structural Synaptic Plasticity.Stabilization of spontaneous neurotransmitter release at ribbon synapses by ribbon-specific subtypes of complexinInteraction of the complexin accessory helix with the C-terminus of the SNARE complex: molecular-dynamics model of the fusion clamp.Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic stateMolecular mechanisms of COMPLEXIN fusion clamp function in synaptic exocytosis revealed in a new Drosophila mutantInsulin signaling controls neurotransmission via the 4eBP-dependent modification of the exocytotic machinery.Complexin Mutants Reveal Partial Segregation between Recycling Pathways That Drive Evoked and Spontaneous NeurotransmissionComplexin synchronizes primed vesicle exocytosis and regulates fusion pore dynamics.Unusual 4p16.3 deletions suggest an additional chromosome region for the Wolf-Hirschhorn syndrome-associated seizures disorder.Adhesion energy can regulate vesicle fusion and stabilize partially fused states.Unique Structural Features of Membrane-Bound C-Terminal Domain Motifs Modulate Complexin Inhibitory Function.Abnormal synaptic vesicle biogenesis in Drosophila synaptogyrin mutants.Complexin facilitates exocytosis and synchronizes vesicle release in two secretory model systems.Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability.A mechanism for exocytotic arrest by the Complexin C-terminusFocused clamping of a single neuronal SNARE complex by complexin under high mechanical tension
P2860
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P2860
Comparative analysis of Drosophila and mammalian complexins as fusion clamps and facilitators of neurotransmitter release.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Comparative analysis of Drosop ...... s of neurotransmitter release.
@en
Comparative analysis of Drosop ...... s of neurotransmitter release.
@nl
type
label
Comparative analysis of Drosop ...... s of neurotransmitter release.
@en
Comparative analysis of Drosop ...... s of neurotransmitter release.
@nl
prefLabel
Comparative analysis of Drosop ...... s of neurotransmitter release.
@en
Comparative analysis of Drosop ...... s of neurotransmitter release.
@nl
P2860
P1476
Comparative analysis of Drosop ...... rs of neurotransmitter release
@en
P2093
Richard W Cho
P2860
P304
P356
10.1016/J.MCN.2010.07.012
P577
2010-07-30T00:00:00Z