about
Characterization of the poly-T variant in the TOMM40 gene in diverse populationsThe Alu neurodegeneration hypothesis: A primate-specific mechanism for neuronal transcription noise, mitochondrial dysfunction, and manifestation of neurodegenerative disease.APOE ε4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African AmericansGenetic variation at a single locus and age of onset for Alzheimer's disease.The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes.Using genetics to enable studies on the prevention of Alzheimer's diseaseThe genetic contributions of SNCA and LRRK2 genes to Lewy Body pathology in Alzheimer's disease.Are APOE ɛ genotype and TOMM40 poly-T repeat length associations with cognitive ageing mediated by brain white matter tract integrity?Alzheimer's disease susceptibility genes APOE and TOMM40, and hippocampal volumes in the Lothian birth cohort 1936.Cerebrospinal fluid cortisol concentrations in healthy elderly are affected by both APOE and TOMM40 variants.Effect of APOE and CD33 on Cognitive Decline.Levels of cerebrospinal fluid neurofilament light protein in healthy elderly vary as a function of TOMM40 variantsA homopolymer polymorphism in the TOMM40 gene contributes to cognitive performance in agingA cytosine-thymine (CT)-rich haplotype in intron 4 of SNCA confers risk for Lewy body pathology in Alzheimer's disease and affects SNCA expression.Novel loci and pathways significantly associated with longevity.A Genetics-based Biomarker Risk Algorithm for Predicting Risk of Alzheimer's Disease.Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced AgesAlzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936.TOMM40 and APOE: Requirements for replication studies of association with age of disease onset and enrichment of a clinical trial.New applications of disease genetics and pharmacogenetics to drug development.Managing genomic and proteomic knowledge.TOMM40'523 variant and cognitive decline in older persons with APOE ε3/3 genotype.Structural variants can be more informative for disease diagnostics, prognostics and translation than current SNP mapping and exon sequencing.New Genetic Approaches to AD: Lessons from APOE-TOMM40 Phylogenetics.Assessment of the COBAS Amplicor HBV Monitor Test for quantitation of serum hepatitis B virus DNA levels.Interactions of 1263W94 with other antiviral agents in inhibition of human cytomegalovirus replication.Understanding the genetics of APOE and TOMM40 and role of mitochondrial structure and function in clinical pharmacology of Alzheimer's disease.On the importance of the "antagonist assumption" to how receptors express themselves.APOE/TOMM40 genetic loci, white matter hyperintensities, and cerebral microbleeds.The SSV Evaluation System: A Tool to Prioritize Short Structural Variants for Studies of Possible Regulatory and Causal VariantsCorrection: Effect of APOE and CD33 on Cognitive Decline.Characterization of APOE and TOMM40 allele frequencies in the Japanese population.The cubic ternary complex receptor-occupancy model. III. resurrecting efficacy.African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles.A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing.The TOMM40 poly-T rs10524523 variant is associated with cognitive performance among non-demented elderly with type 2 diabetes.Family history and TOMM40 '523 interactive associations with memory in middle-aged and Alzheimer's disease cohorts.Genetic analysis of α-synuclein 3' untranslated region and its corresponding microRNAs in relation to Parkinson's disease compared to dementia with Lewy bodies.Neuropathologic features of TOMM40 '523 variant on late-life cognitive decline.Peak alignment of urine NMR spectra using fuzzy warping.
P50
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P50
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Michael W. Lutz
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Michael W. Lutz
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Michael W. Lutz
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Michael W. Lutz
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Michael W. Lutz
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Michael W. Lutz
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Michael W. Lutz
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Michael W. Lutz
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Michael W. Lutz
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Michael W. Lutz
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Michael W. Lutz
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Michael W. Lutz
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Michael W. Lutz
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Michael W. Lutz
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Michael W. Lutz
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P21
P2456
P31
P496
0000-0001-8809-5574