about
Antiinflammatory, gastrosparing, and antiplatelet properties of new NO-donor esters of aspirinMechanism of action of novel NO-releasing furoxan derivatives of aspirin in human plateletsThe Lipophilicity Behavior of Three Catechol-O-methyltransferase (COMT) Inhibitors and Simple AnaloguesLipophilicity behaviour of the Zwitterionic antihistamine cetirizine in phosphatidylcholine liposomes/water systems.Liposome/water lipophilicity: methods, information content, and pharmaceutical applications.Synthesis of some novel organic nitrates and comparative in vitro study of their vasodilator profile.Leishmanicidal activities of novel synthetic furoxan and benzofuroxan derivatives.New praziquantel derivatives containing NO-donor furoxans and related furazans as active agents against Schistosoma mansoni.In vitro pharmacological evaluation of multitarget agents for thromboxane prostanoid receptor antagonism and COX-2 inhibition.A nitric oxide-donor furoxan moiety improves the efficacy of edaravone against early renal dysfunction and injury evoked by ischemia/reperfusionChemokine nitration prevents intratumoral infiltration of antigen-specific T cells.Liposomal nitrooxy-doxorubicin: one step over caelyx in drug-resistant human cancer cells.Doxorubicin-antioxidant co-drugs.Designing multitarget anti-inflammatory agents: chemical modulation of the lumiracoxib structure toward dual thromboxane antagonists-COX-2 inhibitors.Nitric oxide donor doxorubicins accumulate into Doxorubicin-resistant human colon cancer cells inducing cytotoxicity.Nitrooxyacyl derivatives of salicylic acid: aspirin-like molecules that covalently inactivate cyclooxygenase-1.Phenylsulfonylfuroxans as modulators of multidrug-resistance-associated protein-1 and P-glycoprotein.4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues.Synthesis and Biological Evaluation of the First Example of NO-Donor Histone Deacetylase InhibitorHydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds.Synthesis of NO-donor bisphosphonates and their in-vitro action on bone resorption.New 1,4-dihydropyridines endowed with NO-donor and calcium channel agonist properties.Synthesis and voltage-clamp studies of methyl 1,4-dihydro-2, 6-dimethyl-5-nitro-4-(benzofurazanyl)pyridine-3-carboxylate racemates and enantiomers and of their benzofuroxanyl analogues.Novel R-roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents.Amodiaquine analogues containing NO-donor substructures: synthesis and their preliminary evaluation as potential tools in the treatment of cerebral malaria.A new series of amodiaquine analogues modified in the basic side chain with in vitro antileishmanial and antiplasmodial activity.A novel hybrid aspirin-NO-releasing compound inhibits TNFalpha release from LPS-activated human monocytes and macrophages.A rapid screening for cytochrome P450 catalysis on new chemical entities: cytochrome P450 BM3 and 1,2,5-oxadiazole derivatives.Multitarget drugs: synthesis and preliminary pharmacological characterization of zileuton analogues endowed with Dual 5-LO inhibitor and NO-dependent activities.(Nitrooxyacyloxy)methyl esters of aspirin as novel nitric oxide releasing aspirins.Nitrooxymethyl-substituted analogues of rofecoxib: synthesis and pharmacological characterization.Physicochemical profile and in vitro permeation behavior of a new class of non-steroidal anti-inflammatory drug candidates.Synthesis and preliminary pharmacological characterisation of a new class of nitrogen-containing bisphosphonates (N-BPs).N-Substituted analogues of S-nitroso-N-acetyl-D,L-penicillamine: chemical stability and prolonged nitric oxide mediated vasodilatation in isolated rat femoral arteries.Studies on agents with mixed NO-dependent and calcium channel antagonistic vasodilating activities.Searching for balanced hybrid NO-donor 1,4-dihydropyridines with basic properties.Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors.A new class of ibuprofen derivatives with reduced gastrotoxicity.Nitroanilines are the reduction products of benzofuroxan system by oxyhemoglobin (HbO2 2+).Mitochondrial-targeting nitrooxy-doxorubicin: a new approach to overcome drug resistance.
P50
Q28194973-15FCA17E-C399-4F5E-BFA8-120F96B5BDAEQ28218042-8EC76D65-2D2C-41F5-B1E4-B3DE7CD9F7E2Q29542306-383B2EE8-7DF4-4C7F-A406-EADA93D7BD11Q30656849-2FE02CA5-935F-4139-8448-9E75E152EF69Q30909523-7601F5C7-728C-4AEB-85C5-50E6FF31E7FBQ33347110-7EB4AE84-9EEF-4A83-964F-14014EB38C01Q34058373-85991EDB-385D-4482-8189-03651F44AC58Q34163477-1136E755-5F63-43C0-8630-7DE790398367Q34503558-FF7CB259-84EE-4C10-A95B-19B444DBA199Q35193649-B169AADE-5BED-419F-8C21-4E4F7E43201DQ35237477-D9C53DA7-5A98-40C9-A768-D225077B1131Q38972248-B477F6E2-E4F5-4E79-9F65-29EE00A58A34Q39105965-65EC9B1A-C528-4106-A7BC-3D6B6BEDEEC8Q39301982-FBD74ACD-8216-41E4-B681-A5F23F2BD8D7Q39514398-92125EEF-926A-44B4-9806-3C6DAA11042BQ39584172-792F2F41-5214-477F-A6F6-E49F35D71EEEQ39671590-9EFA9425-2A0E-4205-8493-09FD57DA8704Q39712422-9FFAE16D-E713-49C9-95F5-153BA985F0F1Q39772119-360A5E92-1DDF-4363-9E39-D02795CDA958Q40258788-46B5350A-58B0-4740-8A7D-5266BCF54057Q40451895-9DE54FF0-325F-4579-90BA-F35DE88B9785Q40561606-5D6EE9C1-5B34-4718-8DEF-E06BFFDF300FQ40959339-1B63D164-7F18-4DF0-9669-0494D04F1532Q41885497-402F43E2-1D33-4530-BF30-DA8248E818CBQ41933282-8F03D902-5B0D-4F86-95D5-6F3B2687DFF6Q41937512-FB6AE9D8-7890-433F-8B38-51ABC284CCE7Q42417725-E235AE75-79B5-47B2-A31D-E186C17067E3Q42668307-30739DF4-E8F8-410D-AB42-07AC7DF06BC7Q42964832-5296B2E1-7773-4F2D-AE89-7CCF58F00381Q43013158-D3709610-7D52-446C-94CA-96296CEBE666Q43057500-D32398DA-AB37-45CC-8058-365CA9F14C22Q43116859-05C3DA3E-D4BC-42F5-A760-F307953BD424Q43124760-3E686D64-5522-44CB-B6B2-76EA97E33864Q43189343-777C61F6-11AB-4A9B-9B6F-906F01C390F1Q43639286-4CDF281F-5CF7-4888-B5C1-4DEC9C6F6950Q43702247-051DBE11-EF44-414C-9A0D-DFCFD1FA11B5Q43730478-32195BC4-59E0-4547-955D-76E932A84927Q43755656-6F102CF9-EFE8-46B6-92E9-20C0160465B8Q43805730-DAAB982D-15CD-45D3-8334-355CD1C6D117Q43838088-9E8CC073-C211-440A-AA96-F2A6E52F6A72
P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Roberta Fruttero
@ast
Roberta Fruttero
@en
Roberta Fruttero
@es
Roberta Fruttero
@nl
Roberta Fruttero
@sl
type
label
Roberta Fruttero
@ast
Roberta Fruttero
@en
Roberta Fruttero
@es
Roberta Fruttero
@nl
Roberta Fruttero
@sl
prefLabel
Roberta Fruttero
@ast
Roberta Fruttero
@en
Roberta Fruttero
@es
Roberta Fruttero
@nl
Roberta Fruttero
@sl
P106
P1153
7004516159
P21
P31
P496
0000-0001-6726-1254