Two-stage mechanism for activation of the DNA replication checkpoint kinase Cds1 in fission yeast. - Wikidata - awgldk - TriplyDB

Two-stage mechanism for activation of the DNA replication checkpoint kinase Cds1 in fission yeast.

Two-stage mechanism for activation of the DNA replication checkpoint kinase Cds1 in fission yeast.

http://www.wikidata.org/entity/Q42424667

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Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites Activation of the DNA damage checkpoint in mutants defective in DNA replication initiation Use of quantitative mass spectrometric analysis to elucidate the mechanisms of phospho-priming and auto-activation of the checkpoint kinase Rad53 in vivo.Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint Rad4 mainly functions in Chk1-mediated DNA damage checkpoint pathway as a scaffold protein in the fission yeast Schizosaccharomyces pombe Replication fork stability is essential for the maintenance of centromere integrity in the absence of heterochromatin Mcm4 C-terminal domain of MCM helicase prevents excessive formation of single-stranded DNA at stalled replication forks CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation Mechanism of Dun1 activation by Rad53 phosphorylation in Saccharomyces cerevisiae.Fission yeast Hsk1 (Cdc7) kinase is required after replication initiation for induced mutagenesis and proper response to DNA alkylation damage.Brc1-dependent recovery from replication stress.Rif1 is a global regulator of timing of replication origin firing in fission yeast.Continued DNA synthesis in replication checkpoint mutants leads to fork collapse.The Mek1 phosphorylation cascade plays a role in meiotic recombination of Schizosaccharomyces pombe.The Saccharomyces cerevisiae 14-3-3 proteins Bmh1 and Bmh2 directly influence the DNA damage-dependent functions of Rad53.Mek1 kinase is regulated to suppress double-strand break repair between sister chromatids during budding yeast meiosis Mus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint.Cell cycle regulation by checkpoints.Reconstitution of Rad53 activation by Mec1 through adaptor protein Mrc1.A Cds1-mediated checkpoint protects the MBF activator Rep2 from ubiquitination by anaphase-promoting complex/cyclosome-Ste9 at S-phase arrest in fission yeast.Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response.The CINs of the centromere.Multiple functions of the S-phase checkpoint mediator.Hsk1 kinase and Cdc45 regulate replication stress-induced checkpoint responses in fission yeast.Inner nuclear membrane protein Lem2 facilitates Rad3-mediated checkpoint signaling under replication stress induced by nucleotide depletion in fission yeast Cds1 controls the release of Cdc14-like phosphatase Flp1 from the nucleolus to drive full activation of the checkpoint response to replication stress in fission yeast.Multiple pathways can bypass the essential role of fission yeast Hsk1 kinase in DNA replication initiation.Genome-wide characterization of fission yeast DNA replication origins.Mrc1/Claspin: a new role for regulation of origin firing.Checkpoint-Independent Regulation of Origin Firing by Mrc1 through Interaction with Hsk1 Kinase.Mrc1 marks early-firing origins and coordinates timing and efficiency of initiation in fission yeast.Autoinhibition and autoactivation of the DNA replication checkpoint kinase Cds1 The drinking water contaminant dibromoacetonitrile delays G1-S transition and suppresses Chk1 activation at broken replication forks.The phosphorylation network for efficient activation of the DNA replication checkpoint in fission yeast.Hyperactive Cdc2 kinase interferes with the response to broken replication forks by trapping S.pombe Crb2 in its mitotic T215 phosphorylated state.Hydroxyurea Induces Cytokinesis Arrest in Cells Expressing a Mutated Sterol-14α-Demethylase in the Ergosterol Biosynthesis Pathway Essential domains of Schizosaccharomyces pombe Rad8 required for DNA damage response The kinase domain residue serine 173 of Schizosaccharomyces pombe Chk1 kinase is critical for the response to DNA replication stress.Heme deficiency sensitizes yeast cells to oxidative stress induced by hydroxyurea.

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Two-stage mechanism for activation of the DNA replication checkpoint kinase Cds1 in fission yeast.

http://www.wikidata.org/entity/Q42424667

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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2006年论文

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2006年论文

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name

Two-stage mechanism for activa ...... kinase Cds1 in fission yeast.

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Two-stage mechanism for activa ...... kinase Cds1 in fission yeast.

@nl

type

label

Two-stage mechanism for activa ...... kinase Cds1 in fission yeast.

@en

Two-stage mechanism for activa ...... kinase Cds1 in fission yeast.

@nl

prefLabel

Two-stage mechanism for activa ...... kinase Cds1 in fission yeast.

@en

Two-stage mechanism for activa ...... kinase Cds1 in fission yeast.

@nl

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Genes & Development

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Two-stage mechanism for activa ...... kinase Cds1 in fission yeast.

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P2093

Matthew Davenport

http://www.w3.org/2001/XMLSchema#string

Thomas J Kelly

http://www.w3.org/2001/XMLSchema#string

Yong-jie Xu

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P2860

Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.

Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses.

Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro

S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe

Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA

The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

Mrc1 transduces signals of DNA replication stress to activate Rad53.

Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint.

S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex.

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990-1003

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scholarly article

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10.1101/GAD.1406706

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8

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20

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2006-04-01T00:00:00Z

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7161055

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16618806

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1472306

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