Two-stage mechanism for activation of the DNA replication checkpoint kinase Cds1 in fission yeast.
about
Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchangeActivation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sitesActivation of the DNA damage checkpoint in mutants defective in DNA replication initiationUse of quantitative mass spectrometric analysis to elucidate the mechanisms of phospho-priming and auto-activation of the checkpoint kinase Rad53 in vivo.Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpointRad4 mainly functions in Chk1-mediated DNA damage checkpoint pathway as a scaffold protein in the fission yeast Schizosaccharomyces pombeReplication fork stability is essential for the maintenance of centromere integrity in the absence of heterochromatinMcm4 C-terminal domain of MCM helicase prevents excessive formation of single-stranded DNA at stalled replication forksCDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptationMechanism of Dun1 activation by Rad53 phosphorylation in Saccharomyces cerevisiae.Fission yeast Hsk1 (Cdc7) kinase is required after replication initiation for induced mutagenesis and proper response to DNA alkylation damage.Brc1-dependent recovery from replication stress.Rif1 is a global regulator of timing of replication origin firing in fission yeast.Continued DNA synthesis in replication checkpoint mutants leads to fork collapse.The Mek1 phosphorylation cascade plays a role in meiotic recombination of Schizosaccharomyces pombe.The Saccharomyces cerevisiae 14-3-3 proteins Bmh1 and Bmh2 directly influence the DNA damage-dependent functions of Rad53.Mek1 kinase is regulated to suppress double-strand break repair between sister chromatids during budding yeast meiosisMus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint.Cell cycle regulation by checkpoints.Reconstitution of Rad53 activation by Mec1 through adaptor protein Mrc1.A Cds1-mediated checkpoint protects the MBF activator Rep2 from ubiquitination by anaphase-promoting complex/cyclosome-Ste9 at S-phase arrest in fission yeast.Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response.The CINs of the centromere.Multiple functions of the S-phase checkpoint mediator.Hsk1 kinase and Cdc45 regulate replication stress-induced checkpoint responses in fission yeast.Inner nuclear membrane protein Lem2 facilitates Rad3-mediated checkpoint signaling under replication stress induced by nucleotide depletion in fission yeastCds1 controls the release of Cdc14-like phosphatase Flp1 from the nucleolus to drive full activation of the checkpoint response to replication stress in fission yeast.Multiple pathways can bypass the essential role of fission yeast Hsk1 kinase in DNA replication initiation.Genome-wide characterization of fission yeast DNA replication origins.Mrc1/Claspin: a new role for regulation of origin firing.Checkpoint-Independent Regulation of Origin Firing by Mrc1 through Interaction with Hsk1 Kinase.Mrc1 marks early-firing origins and coordinates timing and efficiency of initiation in fission yeast.Autoinhibition and autoactivation of the DNA replication checkpoint kinase Cds1The drinking water contaminant dibromoacetonitrile delays G1-S transition and suppresses Chk1 activation at broken replication forks.The phosphorylation network for efficient activation of the DNA replication checkpoint in fission yeast.Hyperactive Cdc2 kinase interferes with the response to broken replication forks by trapping S.pombe Crb2 in its mitotic T215 phosphorylated state.Hydroxyurea Induces Cytokinesis Arrest in Cells Expressing a Mutated Sterol-14α-Demethylase in the Ergosterol Biosynthesis PathwayEssential domains of Schizosaccharomyces pombe Rad8 required for DNA damage responseThe kinase domain residue serine 173 of Schizosaccharomyces pombe Chk1 kinase is critical for the response to DNA replication stress.Heme deficiency sensitizes yeast cells to oxidative stress induced by hydroxyurea.
P2860
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P2860
Two-stage mechanism for activation of the DNA replication checkpoint kinase Cds1 in fission yeast.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Two-stage mechanism for activa ...... kinase Cds1 in fission yeast.
@en
Two-stage mechanism for activa ...... kinase Cds1 in fission yeast.
@nl
type
label
Two-stage mechanism for activa ...... kinase Cds1 in fission yeast.
@en
Two-stage mechanism for activa ...... kinase Cds1 in fission yeast.
@nl
prefLabel
Two-stage mechanism for activa ...... kinase Cds1 in fission yeast.
@en
Two-stage mechanism for activa ...... kinase Cds1 in fission yeast.
@nl
P2093
P2860
P356
P1433
P1476
Two-stage mechanism for activa ...... kinase Cds1 in fission yeast.
@en
P2093
Matthew Davenport
Thomas J Kelly
Yong-jie Xu
P2860
P304
P356
10.1101/GAD.1406706
P577
2006-04-01T00:00:00Z