about
Genetic draft and quasi-neutrality in large facultatively sexual populationsThe rate of establishment of complex adaptationsWaiting for two mutations: with applications to regulatory sequence evolution and the limits of Darwinian evolutionHuman cancers express a mutator phenotypeEvolutionary analysis of human immunodeficiency virus type 1 therapies based on conditionally replicating vectorsStochastic Tunneling of Two Mutations in a Population of Cancer CellsSteering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic ResistanceAdaptive Landscape by Environment Interactions Dictate Evolutionary Dynamics in Models of Drug ResistanceA New Take on John Maynard Smith's Concept of Protein Space for Understanding Molecular EvolutionContingency and entrenchment in protein evolution under purifying selectionScaling expectations for the time to establishment of complex adaptationsOrganism size promotes the evolution of specialized cells in multicellular digital organismsCryptic genetic variation can make “irreducible complexity” a common mode of adaptation in sexual populationsThe potential for respiratory droplet-transmissible A/H5N1 influenza virus to evolve in a mammalian host.Spatial interactions and cooperation can change the speed of evolution of complex phenotypes.The impact of population size on the evolution of asexual microbes on smooth versus rugged fitness landscapes.Modeling Tumor Clonal Evolution for Drug Combinations DesignAdaptive evolution of complex innovations through stepwise metabolic niche expansion.Inferring fitness landscapes by regression produces biased estimates of epistasis.Selection in spatial stochastic models of cancer: migration as a key modulator of fitnessThe rate of fitness-valley crossing in sexual populations.Experiments on the role of deleterious mutations as stepping stones in adaptive evolutionMutational effects and population dynamics during viral adaptation challenge current modelsEvolutionary capacitance may be favored by natural selection.Negative clonal selection in tumor evolution.The rank ordering of genotypic fitness values predicts genetic constraint on natural selection on landscapes lacking sign epistasis.The resolution of sexual antagonism by gene duplication.Epistasis increases the rate of conditionally neutral substitution in an adapting population.Patterns of proliferative activity in the colonic crypt determine crypt stability and rates of somatic evolution.Symmetric vs. asymmetric stem cell divisions: an adaptation against cancer?The age incidence of chronic myeloid leukemia can be explained by a one-mutation model.The dynamics of alternative pathways to compensatory substitution.Effect of dedifferentiation on time to mutation acquisition in stem cell-driven cancers.The role of the effective population size in compensatory evolution.The genomic landscape of compensatory evolutionStochastic tunneling and metastable states during the somatic evolution of cancer.Toward a general model for the evolutionary dynamics of gene duplicates.Adaptive gene introgression after secondary contact.Imperfect drug penetration leads to spatial monotherapy and rapid evolution of multidrug resistance.Multiple routes to subfunctionalization and gene duplicate specialization.
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Stochastic tunnels in evolutionary dynamics.
@en
Stochastic tunnels in evolutionary dynamics.
@nl
type
label
Stochastic tunnels in evolutionary dynamics.
@en
Stochastic tunnels in evolutionary dynamics.
@nl
prefLabel
Stochastic tunnels in evolutionary dynamics.
@en
Stochastic tunnels in evolutionary dynamics.
@nl
P2860
P1433
P1476
Stochastic tunnels in evolutionary dynamics.
@en
P2093
Franziska Michor
Martin A Nowak
P2860
P304
P356
10.1534/GENETICS.166.3.1571
P407
P50
P577
2004-03-01T00:00:00Z