about
Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survivalThreshold effects of nitric oxide-induced toxicity and cellular responses in wild-type and p53-null human lymphoblastoid cellsN-formylation of lysine in histone proteins as a secondary modification arising from oxidative DNA damagem(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells.Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteinsDefects in purine nucleotide metabolism lead to substantial incorporation of xanthine and hypoxanthine into DNA and RNAA human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-αA quantitative systems approach reveals dynamic control of tRNA modifications during cellular stress2'-O methylation of internal adenosine by flavivirus NS5 methyltransferaseQuantitative analysis of histone modifications: formaldehyde is a source of pathological n(6)-formyllysine that is refractory to histone deacetylasesQuantitative analysis of ribonucleoside modifications in tRNA by HPLC-coupled mass spectrometryResistance to nitric oxide-induced necrosis in heme oxygenase-1 overexpressing pulmonary epithelial cells associated with decreased lipid peroxidationGenomic mapping of phosphorothioates reveals partial modification of short consensus sequencesThe DNA-damage signature in Saccharomyces cerevisiae is associated with single-strand breaks in DNA.Mechanisms of oxidation of guanine in DNA by carbonate radical anion, a decomposition product of nitrosoperoxycarbonate.Photosensitized oxidative DNA damage: from hole injection to chemical product formation and strand cleavage.Oxidation of guanine in G, GG, and GGG sequence contexts by aromatic pyrenyl radical cations and carbonate radical anions: relationship between kinetics and distribution of alkali-labile lesionsOne-electron oxidation of a pyrenyl photosensitizer covalently attached to DNA and competition between its further oxidation and DNA hole injectionQuantification of DNA damage products resulting from deamination, oxidation and reaction with products of lipid peroxidation by liquid chromatography isotope dilution tandem mass spectrometry.An improved method for large-scale preparation of negatively and positively supercoiled plasmid DNA.Quantification of the 2-deoxyribonolactone and nucleoside 5'-aldehyde products of 2-deoxyribose oxidation in DNA and cells by isotope-dilution gas chromatography mass spectrometry: differential effects of gamma-radiation and Fe2+-EDTAIntegrated molecular analysis indicates undetectable change in DNA damage in mice after continuous irradiation at ~ 400-fold natural background radiation.The biological and metabolic fates of endogenous DNA damage productsDNA phosphorothioation is widespread and quantized in bacterial genomes.Diverse cell stresses induce unique patterns of tRNA up- and down-regulation: tRNA-seq for quantifying changes in tRNA copy numberStability of 2'-deoxyxanthosine in DNA.An automated Fpg-based FADU method for the detection of oxidative DNA lesions and screening of antioxidantsDNA methylation impacts gene expression and ensures hypoxic survival of Mycobacterium tuberculosis.28S rRNA is inducibly pseudouridylated by the mTOR pathway translational control in CHO cell culturesChemistry meets biology in colitis-associated carcinogenesistRNA modifications regulate translation during cellular stress.Pathological phenotypes and in vivo DNA cleavage by unrestrained activity of a phosphorothioate-based restriction system in SalmonellaHighly Predictive Reprogramming of tRNA Modifications Is Linked to Selective Expression of Codon-Biased GenesSupercoiling affects the accessibility of glutathione to DNA-bound molecules: positive supercoiling inhibits calicheamicin-induced DNA damage.Reactive nitrogen species in the chemical biology of inflammation.Sequence-dependent variation in the reactivity of 8-Oxo-7,8-dihydro-2'-deoxyguanosine toward oxidation.Reactive species and DNA damage in chronic inflammation: reconciling chemical mechanisms and biological fates.Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer.A system for exposing molecules and cells to biologically relevant and accurately controlled steady-state concentrations of nitric oxide and oxygen.Opportunities to integrate new approaches in genetic toxicology: an ILSI-HESI workshop report.
P50
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P50
description
hulumtues
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onderzoeker
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researcher
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հետազոտող
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name
Peter C. Dedon
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Peter C. Dedon
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Peter C. Dedon
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Peter C. Dedon
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Peter C. Dedon
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type
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Peter C. Dedon
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Peter C. Dedon
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Peter C. Dedon
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Peter C. Dedon
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Peter C. Dedon
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prefLabel
Peter C. Dedon
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Peter C. Dedon
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Peter C. Dedon
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Peter C. Dedon
@nl
Peter C. Dedon
@sl
P106
P1153
7003942489
P21
P31
P496
0000-0003-0011-3067