Effect of YC-1, an NO-independent, superoxide-sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators. - Wikidata - awgldk - TriplyDB

Effect of YC-1, an NO-independent, superoxide-sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators.

Effect of YC-1, an NO-independent, superoxide-sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators.

http://www.wikidata.org/entity/Q42435281

about

Human soluble guanylate cyclase: functional expression and revised isoenzyme family NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential NO-independent regulatory site of direct sGC stimulators like YC-1 and BAY 41-2272 Heme-dependent and independent soluble guanylate cyclase activators and vasodilation.Post-transcriptional regulation of soluble guanylyl cyclase expression in rat aorta NO-independent regulatory site on soluble guanylate cyclase.Release of nitric oxide from endothelial cells stimulated by YC-1, an activator of soluble guanylyl cyclase Protective effects of YC-1 against glutamate induced PC12 cell apoptosis.YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components Nitric oxide down-regulates brain-derived neurotrophic factor secretion in cultured hippocampal neurons Increased cytochrome P4502E1 expression and altered hydroxyeicosatetraenoic acid formation mediate diabetic vascular dysfunction: rescue by guanylyl-cyclase activation.Targeting soluble guanylate cyclase for the treatment of pulmonary hypertension.Activators of soluble guanylate cyclase for the treatment of male erectile dysfunction.Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary disease.YC-1 potentiates nitric oxide-induced relaxation in guinea-pig trachea.Cardiovascular actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vivo studies Pharmacological actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vitro studies YC-1 increases cyclo-oxygenase-2 expression through protein kinase G- and p44/42 mitogen-activated protein kinase-dependent pathways in A549 cells.NO- and haem-independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle.The Rho-kinase inhibitor Y-27632 and the soluble guanylyl cyclase activator BAY41-2272 relax rabbit vaginal wall and clitoral corpus cavernosum The soluble guanylyl cyclase activator YC-1 increases intracellular cGMP and cAMP via independent mechanisms in INS-1E cells Soluble guanylyl cyclase: physiological role as an NO receptor and the potential molecular target for therapeutic application.Nitric oxide-cyclic GMP pathway with some emphasis on cavernosal contractility.Nitric oxide/redox-based signalling as a therapeutic target for penile disorders.Inhibitors of cellular signalling are cytotoxic or block the budded-to-hyphal transition in the pathogenic yeast Candida albicans.A Review of the Pathophysiology and Novel Treatments for Erectile Dysfunction.Oxidative stress and endothelial dysfunction in hypertension.Guanylate cyclase activators, cell volume changes and IOP reduction.Stimulators and activators of soluble guanylate cyclase: review and potential therapeutic indications.Stimulators of soluble guanylyl cyclase: future clinical indications The chemistry and biology of soluble guanylate cyclase stimulators and activators.YC-1, a novel potential anticancer agent, inhibit multidrug-resistant protein via cGMP-dependent pathway.T cell-mediated vascular dysfunction of human allografts results from IFN-gamma dysregulation of NO synthase.Involvement of the cGMP signalling pathway in the regulation of viability in insulin-secreting BRIN-BD11 cells.A functional domain of the alpha1 subunit of soluble guanylyl cyclase is necessary for activation of the enzyme by nitric oxide and YC-1 but is not involved in heme binding.Activation of soluble guanylate cyclase causes relaxation of corpus cavernosum tissue: synergism of nitric oxide and YC-1.Acute blood pressure effects of YC-1-induced activation of soluble guanylyl cyclase in normotensive and hypertensive rats.Stimulation of soluble guanylate cyclase by superoxide dismutase is mediated by NO.YC-1 stimulates the expression of gaseous monoxide-generating enzymes in vascular smooth muscle cells.Effects of the soluble guanylyl cyclase activator, YC-1, on vascular tone, cyclic GMP levels and phosphodiesterase activity.

P2860

Q24314629-33C6A5C0-67EF-4FF9-AA9E-BCDDC94F96F4 Q24656131-049CA22D-AA83-4E50-9591-8141C47B4183 Q24798007-09E5BB0B-B2CC-4CF0-B8F7-0560540327F7 Q27692662-CB1C31C4-D420-465C-94ED-944036572131 Q28567622-41044D03-D90D-4306-AD89-B9956F87D190 Q32165040-4EAAD795-04EB-499E-A809-A82A34E5D851 Q33179221-4281FFA2-FB33-43FF-A7C2-B1CE492EEF1C Q33743118-70A475F0-FF60-42DA-B611-BB9A0A27B21B Q33948966-7E0F7E33-43C1-4803-B7C6-E5C65AF42E77 Q34017513-566191ED-2B1F-4B7F-BF4C-431B4B668AE6 Q34024378-E7322FD5-DB92-4FE8-A1BE-BA313625BD93 Q34179857-E868B5B5-0176-4E28-AAC7-BD233424F71B Q34564998-F1E23A8C-DA32-43CB-853F-2C857658B800 Q35010064-767BD155-1EE0-4722-8009-3B54DED86282 Q35041586-2ABE3EFD-B6FF-46D4-8FA7-7D7B9C5F57C8 Q35044037-C8A43FA0-F04B-461B-A129-6E0406DC755C Q35044042-49F9F059-B361-43E5-B2B4-F50E8724A4D9 Q35044436-5F2EEB28-917D-4ACD-97C9-C5CDD5C6674D Q35044464-CCABB276-732C-4E22-B302-2A67078DD289 Q35044932-AFAA7E73-7CC7-4BF9-A675-AC119912260B Q35188169-10A57492-74A4-410F-B30B-FEB2AC44659D Q35206512-569BC802-3010-4E08-977E-75294325DF33 Q35824102-1E8F261B-FA1C-4995-ADE7-C91D1A35A723 Q36481074-D793DB8B-FE55-4B26-9B76-BA62BC41070E Q37343625-2AC1E75F-8922-423F-AE5E-CB330DA43596 Q37820206-DEA2A23F-4805-453C-8E0B-840B777A3074 Q37867946-1B22167D-6039-4884-A8C8-5CEE2A78F411 Q37969557-B3317E9F-9D54-49FB-94EE-9E1CAF1C8FEB Q38000562-CA87A8A3-39F5-428F-99DF-B8EAB8D69B3F Q38093420-8DAD7FB3-F3AC-4F7E-B2B8-9C3EE231445F Q38130465-4D0BA224-CA9B-4BB6-85E6-5FF906A34861 Q39672848-84240DD3-CDE7-4250-A2EC-D0FD3B288942 Q39989025-C0B75684-07F0-4A65-9B87-8BE967AFCCAB Q40590465-2666F544-79EB-4A97-A548-C521E2BECC4F Q40673658-7A1BE52D-787E-4070-A6CB-F1EE1BDE5577 Q40735472-68D2540A-79E0-458D-8D28-B370027E5608 Q41903134-83DF27E0-39D3-41A3-96EE-328A112747F6 Q41963144-5DC4B196-368C-43A4-9EBF-13541DAE220F Q41983813-C0EEABE4-FF41-4650-8392-3AB9CA45CD5A Q42099241-A0C35CB4-4449-444B-BDE3-E2CD8192D742

P2860

Effect of YC-1, an NO-independent, superoxide-sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators.

http://www.wikidata.org/entity/Q42435281

description

1997 nî lūn-bûn

@nan

1997年の論文

@ja

1997年論文

@yue

1997年論文

@zh-hant

1997年論文

@zh-hk

1997年論文

@zh-mo

1997年論文

@zh-tw

1997年论文

@wuu

1997年论文

@zh

1997年论文

@zh-cn

name

Effect of YC-1, an NO-independ ...... siveness to nitrovasodilators.

@en

Effect of YC-1, an NO-independ ...... siveness to nitrovasodilators.

@nl

type

label

Effect of YC-1, an NO-independ ...... siveness to nitrovasodilators.

@en

Effect of YC-1, an NO-independ ...... siveness to nitrovasodilators.

@nl

prefLabel

Effect of YC-1, an NO-independ ...... siveness to nitrovasodilators.

@en

Effect of YC-1, an NO-independ ...... siveness to nitrovasodilators.

@nl

P1433

Q42435281-488309C9-FCED-41B0-8BCA-2B54C3EC8A01

P1476

Q42435281-4FC856DB-C5A7-4D45-B4BD-5556D0294376

P2093

Q42435281-3B6FEB4A-4D6A-4DCF-9846-1B9AB6752FC3

Q42435281-3E43F880-88D4-4D3A-85AA-35CD41EA30D7

Q42435281-4C90FA95-05C6-4098-8337-1FEF8823F33B

Q42435281-CAAD776F-7C89-4CEE-9A5D-41EFE404052B

Q42435281-E7E4FE56-F70E-4C90-A070-2F35CEF6B6DA

Q42435281-E985D858-8F0D-47C9-8595-BA7BB02A7E06

P2860

Q42435281-64F7DFD8-001F-4DAA-95A3-2AA8095E8458

Q42435281-C3213370-26C5-4BFA-A095-CA818B6B4D95

Q42435281-E40F2E3A-2EAE-4115-BC7F-5BB5677746E7

P304

Q42435281-C43B3701-24FE-4887-BA53-02545A7318EB

P31

Q42435281-CF0875A6-D4C4-4518-B280-327CE5DCFAF2

P356

Q42435281-A96F3111-FA73-4EAB-BDC4-BD5053F1C2DE

P407

Q42435281-6670C51A-4521-451F-AF3B-9F45EE231C65

P433

Q42435281-DB7C383F-8F34-448F-B794-E4F7E3E29B1E

P478

Q42435281-7442E706-F3F1-444A-BB05-505E0BF4A448

P577

Q42435281-044BBDED-C4FE-41DE-A4C5-D655F231DAC7

P5875

Q42435281-665AD032-AEBC-4204-9FDD-544B5D3928AB

P698

Q42435281-E9A8C02F-FB23-4195-9577-41FBC78B77C4

P932

Q42435281-54E0C652-4768-4E5F-9A22-01FCE2A15005

P356

P1433

British Journal of Pharmacology

P1476

Effect of YC-1, an NO-independ ...... siveness to nitrovasodilators.

@en

P2093

Bauersachs J

http://www.w3.org/2001/XMLSchema#string

Busse R

http://www.w3.org/2001/XMLSchema#string

Kast R

http://www.w3.org/2001/XMLSchema#string

Mülsch A

http://www.w3.org/2001/XMLSchema#string

Schäfer A

http://www.w3.org/2001/XMLSchema#string

Stasch JP

http://www.w3.org/2001/XMLSchema#string

P2860

YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase

Specificity of different organic nitrates to elicit NO formation in rabbit vascular tissues and organs in vivo.

Mechanism of anti-proliferation caused by YC-1, an indazole derivative, in cultured rat A10 vascular smooth-muscle cells.

P304

681-689

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/SJ.BJP.0700982

http://www.w3.org/2001/XMLSchema#string

P407

P433

4

http://www.w3.org/2001/XMLSchema#string

P478

120

http://www.w3.org/2001/XMLSchema#string

P577

1997-02-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

14160766

http://www.w3.org/2001/XMLSchema#string

P698

9051308

http://www.w3.org/2001/XMLSchema#string

P932

1564520

http://www.w3.org/2001/XMLSchema#string