Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes.
about
Imaging alterations of cardiomyocyte cAMP microdomains in diseaseInhibition of type 5 phosphodiesterase counteracts β2-adrenergic signalling in beating cardiomyocytesPDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signallingInhibition of phosphodiesterase 2 augments cGMP and cAMP signaling to ameliorate pulmonary hypertension.Efficacy of B-Type Natriuretic Peptide Is Coupled to Phosphodiesterase 2A in Cardiac Sympathetic Neurons.Gene-Gene Associations with the Susceptibility of Kawasaki Disease and Coronary Artery Lesions.Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy.Interaction between phosphodiesterases in the regulation of the cardiac β-adrenergic pathway.Roles of phosphodiesterases in the regulation of the cardiac cyclic nucleotide cross-talk signaling networkOld dog, new tricks: novel cardiac targets and stress regulation by protein kinase G.Temporal and spatial regulation of cAMP signaling in disease: role of cyclic nucleotide phosphodiesterases.New insights in (inter)cellular mechanisms by heart failure with preserved ejection fraction.β-adrenergic receptor signalling and its functional consequences in the diseased heart.Cyclic nucleotide regulation of cardiac sympatho-vagal responsiveness.Molecular Physiology of Membrane Guanylyl Cyclase Receptors.Mechanisms of the cyclic nucleotide cross-talk signaling network in cardiac L-type calcium channel regulation.Cardiac Phosphodiesterases and Their Modulation for Treating Heart Disease.Therapeutic Targeting of PDEs and PI3K in Heart Failure with Preserved Ejection Fraction (HFpEF).Genetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart Failure.PDE2 activity differs in right and left rat ventricular myocardium and differentially regulates β2 adrenoceptor-mediated effects.Response to Wagner et al.: phosphodiesterase-2-anti-adrenergic friend or hypertrophic foe in heart disease?PDE2-mediated cAMP hydrolysis accelerates cardiac fibroblast to myofibroblast conversion and is antagonized by exogenous activation of cGMP signaling pathways.Inhibitors of phosphodiesterases PDE2, PDE3, and PDE4 do not increase the sinoatrial tachycardia of noradrenaline and prostaglandin PGE₁ in mice.In vivo model with targeted cAMP biosensor reveals changes in receptor-microdomain communication in cardiac disease.Imaging of PDE2- and PDE3-Mediated cGMP-to-cAMP Cross-Talk in Cardiomyocytes.Phosphodiesterase 2: anti-adrenergic friend or hypertrophic foe in heart disease?Roles of A-Kinase Anchoring Proteins and Phosphodiesterases in the Cardiovascular System.Phosphodiesterase 2A as a therapeutic target to restore cardiac neurotransmission during sympathetic hyperactivity.The Development of Compartmentation of cAMP Signaling in Cardiomyocytes: The Role of T-Tubules and Caveolae Microdomains.
P2860
Q26785322-285009FB-4FAF-4DE0-8ADB-A65A6F24D4E6Q27967859-4A741A23-E212-4407-88FD-658E39BC9A60Q33112068-B136BAA4-588B-4AEF-B997-F6CD10F24007Q34011572-38F6BE95-E2A7-468F-9D24-17C67FEFAC21Q35806196-4134C748-B366-4986-9B32-8407981F9BADQ35855926-41CBB31C-D819-44F5-85B8-21E7DAF04525Q35987917-DCBEC429-FC4F-4D37-B8C4-726816232E00Q36270020-1A0DEFF0-A029-434D-A26A-E1417E0D7DA8Q36609843-0A116474-9D1E-46CA-A806-F652C17D6C46Q37075920-51D6F38F-FABB-4BDA-8A72-538D8577167DQ38205932-B5EA8D2A-AC55-438C-937F-E0BE53B67BC1Q38246170-6FAC8FC6-B330-4BB5-8CAA-920C9F08FBA4Q38722030-7362E844-7286-4E16-9B44-9FAFD739C640Q38750251-B7C19416-12E1-475D-BC89-1C5E731C36DCQ38794203-4AA0EBFB-CBE1-4C86-98A9-1D7F90C6B9BFQ38862807-1EEB746D-AEC0-4152-B8AE-A00B60B6C85AQ38992600-D2FA2686-1EC1-43D0-9834-EB3BA1C5C034Q39268911-16C14A9B-B63F-47CC-8B18-C801743B791DQ40601692-4C19EA2B-AF26-42C1-9085-05B848331658Q42285592-8F2FD00B-A15C-4C89-B5CA-0889F2C70E21Q42384597-1512601E-EAD1-41B0-8D7F-B7BB75018B69Q42454314-4D5F6540-1C69-4F01-AD2D-F35443C51CDDQ42484617-60F5A067-6683-4AD7-ABB7-792F97588D13Q48749621-942E67E2-3ECC-4D5D-AE6D-7EF6E2C1840CQ49787366-75653883-24EA-499B-A4E0-6D869197EC81Q51554788-0A5C3D79-DD8F-40CE-A9C9-4DFD5D52831BQ52809588-B7D21DE9-3098-4FFC-8893-7EFBF930D867Q55341491-208AA37E-3965-4D4C-A010-BED3F71D7A7FQ55452338-5A92A3E1-9EAB-4F32-9435-AADDA1AEBCEF
P2860
Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Phosphodiesterase-2 is up-regu ...... c responses in cardiomyocytes.
@en
Phosphodiesterase-2 is up-regu ...... c responses in cardiomyocytes.
@nl
type
label
Phosphodiesterase-2 is up-regu ...... c responses in cardiomyocytes.
@en
Phosphodiesterase-2 is up-regu ...... c responses in cardiomyocytes.
@nl
prefLabel
Phosphodiesterase-2 is up-regu ...... c responses in cardiomyocytes.
@en
Phosphodiesterase-2 is up-regu ...... c responses in cardiomyocytes.
@nl
P2093
P50
P1476
Phosphodiesterase-2 is up-regu ...... c responses in cardiomyocytes.
@en
P2093
Ali El-Armouche
Audrey Varin
Christiane Vettel
Danilo Seppelt
Dobromir Dobrev
Florence Lefebvre
Grégoire Vandecasteele
Hind Mehel
Julius Emons
Jérôme Leroy
P304
P356
10.1016/J.JACC.2013.05.057
P407
P577
2013-06-26T00:00:00Z