C-terminal and heparin-binding domains of collagenic tail subunit are both essential for anchoring acetylcholinesterase at the synapse.
about
Protein-anchoring strategy for delivering acetylcholinesterase to the neuromuscular junction.Fell-Muir Lecture: Heparan sulphate and the art of cell regulation: a polymer chain conducts the protein orchestra.COOH-terminal collagen Q (COLQ) mutants causing human deficiency of endplate acetylcholinesterase impair the interaction of ColQ with proteins of the basal lamina.A COLQ missense mutation in Labrador Retrievers having congenital myasthenic syndrome.Assembly and regulation of acetylcholinesterase at the vertebrate neuromuscular junctionCongenital myasthenic syndromes in 2012.What have we learned from the congenital myasthenic syndromesSpecific binding of collagen Q to the neuromuscular junction is exploited to cure congenital myasthenia and to explore bases of myasthenia gravis.Anti-MuSK autoantibodies block binding of collagen Q to MuSK.Current status of the congenital myasthenic syndromes.A COLQ Missense Mutation in Sphynx and Devon Rex Cats with Congenital Myasthenic SyndromeSRSF1 and hnRNP H antagonistically regulate splicing of COLQ exon 16 in a congenital myasthenic syndromeCollagen Q and anti-MuSK autoantibody competitively suppress agrin/LRP4/MuSK signaling.COLQ variant associated with Devon Rex and Sphynx feline hereditary myopathy.hnRNP H enhances skipping of a nonfunctional exon P3A in CHRNA1 and a mutation disrupting its binding causes congenital myasthenic syndromeFurther observations in congenital myasthenic syndromesSynaptic basal lamina-associated congenital myasthenic syndromes.Collagen Q is a key player for developing rational therapy for congenital myasthenia and for dissecting the mechanisms of anti-MuSK myasthenia gravis.Splicing regulation and dysregulation of cholinergic genes expressed at the neuromuscular junction.Most acetylcholinesterase activity of non-nervous tissues and cells arises from the AChE-H transcript.Mutations in the C-terminal domain of ColQ in endplate acetylcholinesterase deficiency compromise ColQ-MuSK interaction.Non-enzymatic developmental functions of acetylcholinesterase--the question of redundancy.Clinical and molecular genetic findings in COLQ-mutant congenital myasthenic syndromes.Acetylcholinesterase dynamics at the neuromuscular junction of live animals.Agrin-LRP4-MuSK signaling as a therapeutic target for myasthenia gravis and other neuromuscular disorders.Rules and tools to predict the splicing effects of exonic and intronic mutations.Collagen Q--a potential target for autoantibodies in myasthenia gravis.
P2860
Q30519561-8E10F20D-CFB1-4271-B1AD-8338D24E1F3FQ30568524-C0CB90BE-76DB-4743-BB2A-B056063F3D94Q33624642-48929730-8549-48D4-AD33-6E9B2037CC59Q34105435-58D6DE14-C452-4894-9BB5-6D0A47C22AC7Q34187396-9F10C995-CF48-4FCD-8008-C3FCD1AD8BA4Q34407051-1139AC87-BB5D-4A2F-8946-CAB5E5F5A0EFQ34632327-D0436787-FF9B-47AC-AEB7-33A92903FB77Q35511648-573B4A52-3935-4463-9B18-E6AAE53AA2D4Q35599522-4DAF948B-686C-40E2-AA77-F13DD035B8D0Q35718489-FE4951ED-9132-457F-99F0-20516E0E0F21Q35761079-401F9076-BEEB-4E33-B08B-270A3663C2B8Q35964255-DC710EC8-DB33-493F-8956-A0FD73E24119Q36044172-904C117B-9DE8-4DC3-B1CF-B6C00DF49C1BQ36260439-96D85866-F560-4F0B-96B9-75C724436D51Q37089623-D79B6FC9-964E-4BAD-B39E-18691EBE8081Q37196071-F8F6C1B7-13D2-4D4E-8D93-905E7AC7CF0FQ38070755-78882466-4DAF-4068-B00C-E63A83F844A6Q38162769-9E472E48-E5C3-4BFA-B2AE-7BB6745C6506Q39078041-16AF009E-8575-43AE-8A3D-C0A557755D9BQ45172161-47529A15-ABC4-4FF9-A891-69B812DE70ABQ46069435-3A87925D-F088-4A18-9F06-D984EBA023CEQ46373925-AC12B326-8314-4458-8BD0-46CBB19EA619Q46819149-3C1A7C86-60ED-4C55-8BCE-4AE4BA12C6B7Q46925592-2D912AB8-274B-4DB0-984D-E6A750A8663AQ47928036-B6B0C644-ABA7-453D-802E-AC9E2EC46B8EQ49832045-482AB31A-11C9-4AA3-867B-7A645B9C9122Q54297679-4387E715-D42D-43F0-A001-8E5093292135
P2860
C-terminal and heparin-binding domains of collagenic tail subunit are both essential for anchoring acetylcholinesterase at the synapse.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
C-terminal and heparin-binding ...... cholinesterase at the synapse.
@en
C-terminal and heparin-binding ...... cholinesterase at the synapse.
@nl
type
label
C-terminal and heparin-binding ...... cholinesterase at the synapse.
@en
C-terminal and heparin-binding ...... cholinesterase at the synapse.
@nl
prefLabel
C-terminal and heparin-binding ...... cholinesterase at the synapse.
@en
C-terminal and heparin-binding ...... cholinesterase at the synapse.
@nl
P2093
P2860
P356
P1476
C-terminal and heparin-binding ...... cholinesterase at the synapse.
@en
P2093
Andrew G Engel
Lewis M Kimbell
Richard L Rotundo
P2860
P304
10997-11005
P356
10.1074/JBC.M305462200
P407
P50
P577
2003-12-31T00:00:00Z