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The donor substrate specificity of the human beta 1,3-glucuronosyltransferase I toward UDP-glucuronic acid is determined by two crucial histidine and arginine residuesEvidence of calcium-dependent pathway in the regulation of human beta1,3-glucuronosyltransferase-1 (GlcAT-I) gene expression: a key enzyme in proteoglycan synthesisSubstrate specificity of the human UDP-glucuronosyltransferase UGT2B4 and UGT2B7. Identification of a critical aromatic amino acid residue at position 33Targeting of Proteoglycan Synthesis Pathway: A New Strategy to Counteract Excessive Matrix Proteoglycan Deposition and Transforming Growth Factor-β1-Induced Fibrotic Phenotype in Lung FibroblastsModulation of xylosyltransferase I expression provides a mechanism regulating glycosaminoglycan chain synthesis during cartilage destruction and repairStructure of UDP-glucuronosyltransferases in membranes.Defective initiation of glycosaminoglycan synthesis due to B3GALT6 mutations causes a pleiotropic Ehlers-Danlos-syndrome-like connective tissue disorder.The functional glycosyltransferase signature sequence of the human beta 1,3-glucuronosyltransferase is a XDD motif.Xylosyltransferase-I regulates glycosaminoglycan synthesis during the pathogenic process of human osteoarthritis.Phosphorylation and sulfation of oligosaccharide substrates critically influence the activity of human beta1,4-galactosyltransferase 7 (GalT-I) and beta1,3-glucuronosyltransferase I (GlcAT-I) involved in the biosynthesis of the glycosaminoglycan-proThe UDP-glucuronosyltransferases of the blood-brain barrier: their role in drug metabolism and detoxication.The human UDP-glucuronosyltransferases: structural aspects and drug glucuronidation.Phylogenetic and mutational analyses reveal key residues for UDP-glucuronic acid binding and activity of beta1,3-glucuronosyltransferase I (GlcAT-I)Insights on membrane topology and structure/function of UDP-glucuronosyltransferases.Recent structures, evolution and mechanisms of glycosyltransferases.'Click'-xylosides as initiators of the biosynthesis of glycosaminoglycans: Comparison of mono-xylosides with xylobiosides.The 2017 international classification of the Ehlers-Danlos syndromes.The Ehlers-Danlos syndromes, rare types.Epigenetics: methylation-associated repression of heparan sulfate 3-O-sulfotransferase gene expression contributes to the invasive phenotype of H-EMC-SS chondrosarcoma cells.The importance of cysteine 126 in the human liver UDP-glucuronosyltransferase UGT1A6.Identification of key functional residues in the active site of human {beta}1,4-galactosyltransferase 7: a major enzyme in the glycosaminoglycan synthesis pathway.Probing the acceptor active site organization of the human recombinant β1,4-galactosyltransferase 7 and design of xyloside-based inhibitors.
P50
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P50
description
onderzoeker
@nl
name
Sylvie Fournel-Gigleux
@ast
Sylvie Fournel-Gigleux
@en
Sylvie Fournel-Gigleux
@es
Sylvie Fournel-Gigleux
@nl
Sylvie Fournel-Gigleux
@sl
type
label
Sylvie Fournel-Gigleux
@ast
Sylvie Fournel-Gigleux
@en
Sylvie Fournel-Gigleux
@es
Sylvie Fournel-Gigleux
@nl
Sylvie Fournel-Gigleux
@sl
prefLabel
Sylvie Fournel-Gigleux
@ast
Sylvie Fournel-Gigleux
@en
Sylvie Fournel-Gigleux
@es
Sylvie Fournel-Gigleux
@nl
Sylvie Fournel-Gigleux
@sl