Effects of insulin on steady state kinetics of GLUT4 subcellular distribution in rat adipocytes. Evidence of constitutive GLUT4 recycling.
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Contraction stimulates translocation of glucose transporter GLUT4 in skeletal muscle through a mechanism distinct from that of insulinCloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscleSites of glucose transporter-4 vesicle fusion with the plasma membrane correlate spatially with microtubulesInsulin resistance and the disruption of Glut4 trafficking in skeletal muscleSyntaxin 4 heterozygous knockout mice develop muscle insulin resistanceInsulin-regulated aminopeptidase is a key regulator of GLUT4 trafficking by controlling the sorting of GLUT4 from endosomes to specialized insulin-regulated vesiclesInsulin signaling diverges into Akt-dependent and -independent signals to regulate the recruitment/docking and the fusion of GLUT4 vesicles to the plasma membraneActin filaments play a critical role in insulin-induced exocytotic recruitment but not in endocytosis of GLUT4 in isolated rat adipocytes.Kinetic evidence for unique regulation of GLUT4 trafficking by insulin and AMP-activated protein kinase activators in L6 myotubesInsulin-regulated release from the endosomal recycling compartment is regulated by budding of specialized vesicles.Insulin can regulate GLUT4 internalization by signaling to Rab5 and the motor protein dynein.Rab5 activity regulates GLUT4 sorting into insulin-responsive and non-insulin-responsive endosomal compartments: a potential mechanism for development of insulin resistanceKinetic evidence that Glut4 follows different endocytic pathways than the receptors for transferrin and alpha2-macroglobulin.Conventional kinesin KIF5B mediates insulin-stimulated GLUT4 movements on microtubulesgp160, a tissue-specific marker for insulin-activated glucose transportGLUT4 is retained by an intracellular cycle of vesicle formation and fusion with endosomesGLUT-4 NH2 terminus contains a phenylalanine-based targeting motif that regulates intracellular sequestrationExofacial epitope-tagged glucose transporter chimeras reveal COOH-terminal sequences governing cellular localization.The amino terminus of GLUT4 functions as an internalization motif but not an intracellular retention signal when substituted for the transferrin receptor cytoplasmic domainA double leucine within the GLUT4 glucose transporter COOH-terminal domain functions as an endocytosis signal.Insulin resistance, diabetes, and the insulin-regulated trafficking of GLUT-4.Induction of caveolin during adipogenesis and association of GLUT4 with caveolin-rich vesicles.Distinct signals in the GLUT4 glucose transporter for internalization and for targeting to an insulin-responsive compartment.GLUT4 and transferrin receptor are differentially sorted along the endocytic pathway in CHO cellsThe ras signaling pathway mimics insulin action on glucose transporter translocationInsulin signaling and the regulation of glucose transport.Syntaxin 4, VAMP2, and/or VAMP3/cellubrevin are functional target membrane and vesicle SNAP receptors for insulin-stimulated GLUT4 translocation in adipocytesDisruption of cortical actin in skeletal muscle demonstrates an essential role of the cytoskeleton in glucose transporter 4 translocation in insulin-sensitive tissues.Chromium picolinate positively influences the glucose transporter system via affecting cholesterol homeostasis in adipocytes cultured under hyperglycemic diabetic conditionsThe formation of an insulin-responsive vesicular cargo compartment is an early event in 3T3-L1 adipocyte differentiation.Specialized sorting of GLUT4 and its recruitment to the cell surface are independently regulated by distinct Rabs.Separation of insulin signaling into distinct GLUT4 translocation and activation steps.Insulin stimulation of GLUT4 exocytosis, but not its inhibition of endocytosis, is dependent on RabGAP AS160.Multilevel regulation of an α-arrestin by glucose depletion controls hexose transporter endocytosis.Insulin-responsive compartments containing GLUT4 in 3T3-L1 and CHO cells: regulation by amino acid concentrationsMuscling in on GLUT4 kinetics.The glucose transporter family: structure, function and tissue-specific expression.Analysis of the co-localization of the insulin-responsive glucose transporter (GLUT4) and the trans Golgi network marker TGN38 within 3T3-L1 adipocytes.Chloroquine inhibits glucose-transporter recruitment induced by insulin in rat adipocytes independently of its action on endomembrane pH.Comparison of glucose-transporter-containing vesicles from rat fat and muscle tissues: evidence for a unique endosomal compartment.
P2860
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P2860
Effects of insulin on steady state kinetics of GLUT4 subcellular distribution in rat adipocytes. Evidence of constitutive GLUT4 recycling.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Effects of insulin on steady s ...... constitutive GLUT4 recycling.
@en
Effects of insulin on steady s ...... constitutive GLUT4 recycling.
@nl
type
label
Effects of insulin on steady s ...... constitutive GLUT4 recycling.
@en
Effects of insulin on steady s ...... constitutive GLUT4 recycling.
@nl
prefLabel
Effects of insulin on steady s ...... constitutive GLUT4 recycling.
@en
Effects of insulin on steady s ...... constitutive GLUT4 recycling.
@nl
P2093
P1476
Effects of insulin on steady s ...... constitutive GLUT4 recycling.
@en
P2093
P304
17710-17715
P407
P577
1992-09-01T00:00:00Z