about
Targeted lipidomics in Drosophila melanogaster identifies novel 2-monoacylglycerols and N-acyl amidesCloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brainRobo1 and Robo2 are homophilic binding molecules that promote axonal growthInter-residue distances derived from fold contact propensities correlate with evolutionary substitution costsLoss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out miceGanglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonistsTranscriptional basis for the inhibition of neural stem cell proliferation and migration by the TGFβ-family member GDF11Regional effects of endocannabinoid, BDNF and FGF receptor signalling on neuroblast motility and guidance along the rostral migratory stream.RalA promotes a direct exocyst-Par6 interaction to regulate polarity in neuronal developmentThe COX-2 inhibitors, meloxicam and nimesulide, suppress neurogenesis in the adult mouse brain.The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.Drebrin regulates neuroblast migration in the postnatal mammalian brain.Fascin regulates the migration of subventricular zone-derived neuroblasts in the postnatal brain.Receptors for myelin inhibitors: Structures and therapeutic opportunities.Nucleofection of rodent neuroblasts to study neuroblast migration in vitro.In vivo postnatal electroporation and time-lapse imaging of neuroblast migration in mouse acute brain slices.DAGL-dependent endocannabinoid signalling: roles in axonal pathfinding, synaptic plasticity and adult neurogenesis.The diacylglycerol lipases: structure, regulation and roles in and beyond endocannabinoid signallingThe molecular interplay between endocannabinoid and neurotrophin signals in the nervous system and beyond.A diacylglycerol lipase-CB2 cannabinoid pathway regulates adult subventricular zone neurogenesis in an age-dependent manner.A novel live cell assay to measure diacylglycerol lipase α activityThe molecular basis of the cooperation between EGF, FGF and eCB receptors in the regulation of neural stem cell function.Endocannabinoids regulate the migration of subventricular zone-derived neuroblasts in the postnatal brain.Down-regulation of diacylglycerol lipase-alpha during neural stem cell differentiation: identification of elements that regulate transcription.The fibroblast growth factor receptor acid box is essential for interactions with N-cadherin and all of the major isoforms of neural cell adhesion molecule.Identification of an N-cadherin motif that can interact with the fibroblast growth factor receptor and is required for axonal growth.The FGFR1 inhibitor PD 173074 selectively and potently antagonizes FGF-2 neurotrophic and neurotropic effects.An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling.Nanoscale Structural Plasticity of the Active Zone Matrix Modulates Presynaptic Function.Overcoming amino-Nogo-induced inhibition of cell spreading and neurite outgrowth by 12-O-tetradecanoylphorbol-13-acetate-type tumor promoters.Neuroglian and FasciclinII can promote neurite outgrowth via the FGF receptor Heartless.The FGF receptor uses the endocannabinoid signaling system to couple to an axonal growth responseOvercoming the inhibitors of myelin with a novel neurotrophin strategy.Dimeric versions of two short N-cadherin binding motifs (HAVDI and INPISG) function as N-cadherin agonists.Polysialyltransferase ST8Sia II (STX) polysialylates all of the major isoforms of NCAM and facilitates neurite outgrowth.A retinoic acid receptor beta agonist (CD2019) overcomes inhibition of axonal outgrowth via phosphoinositide 3-kinase signalling in the injured adult spinal cord.Amphotericin B, identified from a natural product screen, antagonizes CNS inhibitors to promote axon growth via activation of an Akt pathway in neurons.BDNF regulates neuronal sensitivity to endocannabinoids.Direct measurement of local raised subplasmalemmal calcium concentrations in growth cones advancing on an N-cadherin substrate.The endocannabinoid receptor, CB1, is required for normal axonal growth and fasciculation.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Patrick Doherty
@ast
Patrick Doherty
@en
Patrick Doherty
@es
Patrick Doherty
@nl
Patrick Doherty
@sl
type
label
Patrick Doherty
@ast
Patrick Doherty
@en
Patrick Doherty
@es
Patrick Doherty
@nl
Patrick Doherty
@sl
prefLabel
Patrick Doherty
@ast
Patrick Doherty
@en
Patrick Doherty
@es
Patrick Doherty
@nl
Patrick Doherty
@sl
P106
P21
P2456
P31
P496
0000-0002-0407-5689