about
IRS1-independent defects define major nodes of insulin resistanceInsulin resistance is a cellular antioxidant defense mechanismDeclining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during agingNiclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetesMitochondrial stress signaling promotes cellular adaptationsActivation of AMPK by bitter melon triterpenoids involves CaMKKβDilinoleoyl-phosphatidic acid mediates reduced IRS-1 tyrosine phosphorylation in rat skeletal muscle cells and mouse muscleThe role of mitochondrial glycerol-3-phosphate acyltransferase-1 in regulating lipid and glucose homeostasis in high-fat diet fed miceAn Actn3 knockout mouse provides mechanistic insights into the association between alpha-actinin-3 deficiency and human athletic performanceGenetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation.Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle.Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivityAcute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity.NF1 is a critical regulator of muscle development and metabolismHigh-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db miceIdentification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity.PPARα-independent actions of omega-3 PUFAs contribute to their beneficial effects on adiposity and glucose homeostasisExploring the relationship between α-actinin-3 deficiency and obesity in mice and humans.Differing endoplasmic reticulum stress response to excess lipogenesis versus lipid oversupply in relation to hepatic steatosis and insulin resistance.Overfeeding reduces insulin sensitivity and increases oxidative stress, without altering markers of mitochondrial content and function in humans.Loss of Krüppel-like factor 3 (KLF3/BKLF) leads to upregulation of the insulin-sensitizing factor adipolin (FAM132A/CTRP12/C1qdc2).High passage MIN6 cells have impaired insulin secretion with impaired glucose and lipid oxidation.The effect of exercise on the skeletal muscle phospholipidome of rats fed a high-fat dietThe ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed miceCholesterol effect on the dipole potential of lipid membranes.Mitochondrial dysfunction and insulin resistance: an update.The evolution of insulin resistance in muscle of the glucose infused ratPPARδ agonists have opposing effects on insulin resistance in high fat-fed rats and mice due to different metabolic responses in muscle.The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathwayOverexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistancePharmacological PPARα activation markedly alters plasma turnover of the amino acids glycine, serine and arginine in the rat.Identification of BMP and activin membrane-bound inhibitor (BAMBI) as a potent negative regulator of adipogenesis and modulator of autocrine/paracrine adipogenic factors.The evolution of endothermy: role for membranes and molecular activity.Overexpression of manganese superoxide dismutase ameliorates high-fat diet-induced insulin resistance in rat skeletal muscle.Disparate metabolic response to fructose feeding between different mouse strainsLimits to physical performance and metabolism across species.Muscle insulin resistance: a case of fat overconsumption, not mitochondrial dysfunction.Minimal impact of age and housing temperature on the metabolic phenotype of Acc2-/- mice.Fast exchange fluxes around the pyruvate node: a leaky cell model to explain the gain and loss of unlabelled and labelled metabolites in a tracer experiment.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Nigel Turner
@ast
Nigel Turner
@en
Nigel Turner
@es
Nigel Turner
@nl
Nigel Turner
@sl
type
label
Nigel Turner
@ast
Nigel Turner
@en
Nigel Turner
@es
Nigel Turner
@nl
Nigel Turner
@sl
prefLabel
Nigel Turner
@ast
Nigel Turner
@en
Nigel Turner
@es
Nigel Turner
@nl
Nigel Turner
@sl
P1053
H-7176-2013
P106
P1153
7202573171
P21
P2798
P31
P3829
P496
0000-0002-0119-9328