BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells.
about
A NIK-IKKα module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1BRCA1 is a negative modulator of the PRC2 complexStem cell technology in breast cancer: current status and potential applicationsDevelopmental signaling pathways regulating mammary stem cells and contributing to the etiology of triple-negative breast cancerP-cadherin and the journey to cancer metastasisOf mice and women: a comparative tissue biology perspective of breast stem cells and differentiationThe mammary stem cell hierarchy: a looking glass into heterogeneous breast cancer landscapesBRCA1 and estrogen/estrogen receptor in breast cancer: where they interact?Epithelial-mesenchymal plasticity of breast cancer stem cells: implications for metastasis and therapeutic resistanceCrosstalk of the Insulin-Like Growth Factor Receptor with the Wnt Signaling Pathway in Breast CancerSLUG: Critical regulator of epithelial cell identity in breast development and cancerMammary stem cells and the differentiation hierarchy: current status and perspectivesLuminal progenitors restrict their lineage potential during mammary gland developmentMammary gland stem cells and their application in breast cancerGenetically engineered mouse models in oncology research and cancer medicineThe Sharing Experimental Animal Resources, Coordinating Holdings (SEARCH) Framework: Encouraging Reduction, Replacement, and Refinement in Animal ResearchA phenotypic mouse model of basaloid breast tumorsDistinct effects of EGFR ligands on human mammary epithelial cell differentiationPalb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancerPhysiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumorsROCK1 inhibition promotes the self-renewal of a novel mouse mammary cancer stem cell.Collective invasion in breast cancer requires a conserved basal epithelial program.BRCA1 modulates the expression of hnRNPA2B1 and KHSRP.RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland.The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment.In vivo models in breast cancer research: progress, challenges and future directions.Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungsTAp63 suppresses mammary tumorigenesis through regulation of the Hippo pathway.Tip30 controls differentiation of murine mammary luminal progenitor to estrogen receptor-positive luminal cell through regulating FoxA1 expressionContribution of an alveolar cell of origin to the high-grade malignant phenotype of pregnancy-associated breast cancerPhenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland.Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity.BRCA1 controls the cell division axis and governs ploidy and phenotype in human mammary cells.Basal but not luminal mammary epithelial cells require PI3K/mTOR signaling for Ras-driven overgrowth.Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis.Differentiation generates paracrine cell pairs that maintain basaloid mouse mammary tumors: proof of concept.Oxidative stress and counteracting mechanisms in hormone receptor positive, triple-negative and basal-like breast carcinomasConcise review: breast cancer stem cells: regulatory networks, stem cell niches, and disease relevanceDistinct EMT programs control normal mammary stem cells and tumour-initiating cells.Self-renewing Pten-/- TP53-/- protospheres produce metastatic adenocarcinoma cell lines with multipotent progenitor activity.
P2860
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P2860
BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
BRCA1 basal-like breast cancer ...... and not from basal stem cells.
@en
BRCA1 basal-like breast cancer ...... and not from basal stem cells.
@nl
type
label
BRCA1 basal-like breast cancer ...... and not from basal stem cells.
@en
BRCA1 basal-like breast cancer ...... and not from basal stem cells.
@nl
prefLabel
BRCA1 basal-like breast cancer ...... and not from basal stem cells.
@en
BRCA1 basal-like breast cancer ...... and not from basal stem cells.
@nl
P2093
P50
P1433
P1476
BRCA1 basal-like breast cancer ...... and not from basal stem cells.
@en
P2093
Afshan McCarthy
Alan Mackay
Andrew Tutt
Felipe C Geyer
Fiona-Ann Magnay
Gemma Molyneux
Howard Kendrick
P304
P356
10.1016/J.STEM.2010.07.010
P407
P577
2010-09-01T00:00:00Z