The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells. - Wikidata - awgldk - TriplyDB

The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells.

The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells.

http://www.wikidata.org/entity/Q42481082

about

The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers Akt kinases in breast cancer and the results of adjuvant therapy Loss of cellular adhesion to matrix induces p53-independent expression of PTEN tumor suppressor Differential responses to doxorubicin-induced phosphorylation and activation of Akt in human breast cancer cells.Circadian disruption and breast cancer: an epigenetic link?PTEN activity could be a predictive marker of trastuzumab efficacy in the treatment of ErbB2-overexpressing breast cancer FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines PTEN is a protein tyrosine phosphatase for IRS1 Critical role of PTEN in the coupling between PI3K/Akt and JNK1/2 signaling in ischemic brain injury Registered report: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology TOR signaling.Lipid raft localization of EGFR alters the response of cancer cells to the EGFR tyrosine kinase inhibitor gefitinib Inhibition of proliferation by PERK regulates mammary acinar morphogenesis and tumor formation.Oncogenic ras-induced down-regulation of autophagy mediator Beclin-1 is required for malignant transformation of intestinal epithelial cells Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo.An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice.Akt phosphorylation at Ser473 predicts benefit of paclitaxel chemotherapy in node-positive breast cancer.Phosphatidylinositol 3-kinases in tumor progression.Increased p50/p50 NF-kappaB activation in human papillomavirus type 6- or type 11-induced laryngeal papilloma tissue.Role of hypoxia and EGF on expression, activity, localization and phosphorylation of carbonic anhydrase IX in MDA-MB-231 breast cancer cells.Effect of tumor suppressor PTEN gene on apoptosis and cell cycle of human airway smooth muscle cells.LKB1 (XEEK1) regulates Wnt signalling in vertebrate development.Indole-3-carbinol prevents PTEN loss in cervical cancer in vivo Odontogenic ameloblast-associated protein (ODAM) inhibits growth and migration of human melanoma cells and elicits PTEN elevation and inactivation of PI3K/AKT signaling.Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma.Negative Regulation of Receptor Tyrosine Kinase (RTK) Signaling: A Developing Field Suppression of gastric cancer growth by adenovirus-mediated transfer of the PTEN gene.Autophagic vacuolation induced by excess ROS generation in HABP1/p32/gC1qR overexpressing fibroblasts and its reversal by polymeric hyaluronan.AEG-1 promotes anoikis resistance and orientation chemotaxis in hepatocellular carcinoma cells.Epigenetics in breast and prostate cancer Autophagy regulation in cancer development and therapy.Destination 'lysosome': a target organelle for tumour cell killing?Oncogenic ras-induced down-regulation of pro-apoptotic protease caspase-2 is required for malignant transformation of intestinal epithelial cells.The receptor tyrosine kinase EphA2 is a direct target gene of hypermethylated in cancer 1 (HIC1).Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3.Increased signalling of EGFR and IGF1R, and deregulation of PTEN/PI3K/Akt pathway are related with trastuzumab resistance in HER2 breast carcinomas.Gene expression in breastmilk cells is associated with maternal and infant characteristics.Integrin alpha4beta1 regulates migration across basement membranes by lung fibroblasts: a role for phosphatase and tensin homologue deleted on chromosome 10 Intracellular delivery of the PTEN protein using cationic lipidoids for cancer therapy.PTEN expression as a predictor for the response to trastuzumab-based therapy in Her-2 overexpressing metastatic breast cancer.

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The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells.

http://www.wikidata.org/entity/Q42481082

description

1999 nî lūn-bûn

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年论文

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1999年论文

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1999年论文

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name

The PTEN/MMAC1/TEP tumor suppr ...... noikis in breast cancer cells.

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The PTEN/MMAC1/TEP tumor suppr ...... noikis in breast cancer cells.

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type

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The PTEN/MMAC1/TEP tumor suppr ...... noikis in breast cancer cells.

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The PTEN/MMAC1/TEP tumor suppr ...... noikis in breast cancer cells.

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prefLabel

The PTEN/MMAC1/TEP tumor suppr ...... noikis in breast cancer cells.

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The PTEN/MMAC1/TEP tumor suppr ...... noikis in breast cancer cells.

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The PTEN/MMAC1/TEP tumor suppr ...... noikis in breast cancer cells.

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B Cuevas

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G B Mills

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H Khan

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K Siminovitch

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M A Davies

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M C Hung

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M Mao

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P Steck

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R LaPushin

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R Zinner

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P2860

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

Alterations of PTEN/MMAC1, a candidate tumor suppressor gene, and its homologue, PTH2, in small cell lung cancer cell lines

Regulation of cell death protease caspase-9 by phosphorylation

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

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7034-7045

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10.1038/SJ.ONC.1203183

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