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A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptorSpecific detection of non-functional human P2X(7) receptors in HEK293 cells and B-lymphocytesPoint mutations confer loss of ATP-induced human P2X(7) receptor functionP2X(7) is a scavenger receptor for apoptotic cells in the absence of its ligand, extracellular ATP.A new role for the P2X7 receptor: a scavenger receptor for bacteria and apoptotic cells in the absence of serum and extracellular ATPP2X7 receptor-mediated scavenger activity of mononuclear phagocytes toward non-opsonized particles and apoptotic cells is inhibited by serum glycoproteins but remains active in cerebrospinal fluid.Non-synonymous polymorphisms in the P2RX ( 4 ) are related to bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients.Genetics of the P2X7 receptor and human disease.Epistasis with HLA DR3 implicates the P2X7 receptor in the pathogenesis of primary Sjögren's syndrome.An Arg307 to Gln polymorphism within the ATP-binding site causes loss of function of the human P2X7 receptor.A loss-of-function polymorphism in the human P2X4 receptor is associated with increased pulse pressure.Extracellular ATP dissociates nonmuscle myosin from P2X(7) complex: this dissociation regulates P2X(7) pore formation.A rare functional haplotype of the P2RX4 and P2RX7 genes leads to loss of innate phagocytosis and confers increased risk of age-related macular degeneration.Innate phagocytosis by peripheral blood monocytes is altered in Alzheimer's disease.Two haplotypes of the P2X(7) receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1beta secretion.Shear stress modulates endothelial KLF2 through activation of P2X4.P2Y(11) receptor expression by human lymphocytes: evidence for two cAMP-linked purinoceptors.A quantitative method for routine measurement of cell surface P2X7 receptor function in leucocyte subsets by two-colour time-resolved flow cytometry.A quantitative method for measuring innate phagocytosis by human monocytes using real-time flow cytometry.Rapid ATP-induced release of matrix metalloproteinase 9 is mediated by the P2X7 receptor.P2X7 receptors mediate innate phagocytosis by human neural precursor cells and neuroblasts.A 5' intronic splice site polymorphism leads to a null allele of the P2X7 gene in 1-2% of the Caucasian population.Functional significance of P2RX7 polymorphisms associated with affective mood disordersP2X7 Receptors Regulate Phagocytosis and Proliferation in Adult Hippocampal and SVZ Neural Progenitor Cells: Implications for Inflammation in NeurogenesisP2X7 as a scavenger receptor for innate phagocytosis in the brain
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Ben J. Gu
@ast
Ben J. Gu
@en
Ben J. Gu
@es
Ben J. Gu
@nl
Ben J. Gu
@sl
type
label
Ben J. Gu
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Ben J. Gu
@en
Ben J. Gu
@es
Ben J. Gu
@nl
Ben J. Gu
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altLabel
Baijun Gu
@en
prefLabel
Ben J. Gu
@ast
Ben J. Gu
@en
Ben J. Gu
@es
Ben J. Gu
@nl
Ben J. Gu
@sl
P106
P1153
7201864433
P21
P31
P496
0000-0001-5500-4453