Functional role of a conserved motif in TM6 of the rat mu opioid receptor: constitutively active and inactive receptors result from substitutions of Thr6.34(279) with Lys and Asp.
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The relative potency of inverse opioid agonists and a neutral opioid antagonist in precipitated withdrawal and antagonism of analgesia and toxicityEnhanced spontaneous activity of the mu opioid receptor by cysteine mutations: characterization of a tool for inverse agonist screeningTwo distinct conformations of helix 6 observed in antagonist-bound structures of a 1-adrenergic receptorCrystal structure of the µ-opioid receptor bound to a morphinan antagonistComputationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding.Brain region-specific N-glycosylation and lipid rafts association of the rat mu opioid receptorModeling activated states of GPCRs: the rhodopsin template.Search for the "ideal analgesic" in pain treatment by engineering the mu-opioid receptor.The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors.Homology modeling of opioid receptor-ligand complexes using experimental constraintsExploring molecular mechanisms of ligand recognition by opioid receptors with metadynamics.K303⁶·⁵⁸ in the μ opioid (MOP) receptor is important in conferring selectivity for covalent binding of β-funaltrexamine (β-FNA).Characterization of G protein coupling mediated by the conserved D134(3.49) of DRY motif, M241(6.34), and F251(6.44) residues on human CXCR1.Conformational changes of G protein-coupled receptors during their activation by agonist binding.Structural Determinants for the Binding of Morphinan Agonists to the μ-Opioid ReceptorHallucinogen actions on 5-HT receptors reveal distinct mechanisms of activation and signaling by G protein-coupled receptors.Agonist treatment did not affect association of mu opioid receptors with lipid rafts and cholesterol reduction had opposite effects on the receptor-mediated signaling in rat brain and CHO cellsDifferential dynamics in the G protein-coupled receptor rhodopsin revealed by solution NMR.Detection of the endogenous mu opioid receptor (mopr) in brainA common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability.Two intracellular helices of G-protein coupling receptors could generally support oligomerization and coupling with transducers.X-ray structural information of GPCRs in drug design: what are the limitations and where do we go?Insight into the mechanism of dopamine D1-like receptor activation. Evidence for a molecular interplay between the third extracellular loop and the cytoplasmic tail.Drug Binding Poses Relate Structure with Efficacy in the μ Opioid Receptor.Insights into the function of opioid receptors from molecular dynamics simulations of available crystal structures.Molecular details of the activation of the μ opioid receptor.The third intracellular loop stabilizes the inactive state of the neuropeptide Y1 receptor.Conserved helix 7 tyrosine acts as a multistate conformational switch in the 5HT2C receptor. Identification of a novel "locked-on" phenotype and double revertant mutations.Molecular details of dimerization kinetics reveal negligible populations of transient µ-opioid receptor homodimers at physiological concentrations.
P2860
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P2860
Functional role of a conserved motif in TM6 of the rat mu opioid receptor: constitutively active and inactive receptors result from substitutions of Thr6.34(279) with Lys and Asp.
description
2001 nî lūn-bûn
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2001年の論文
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2001年学术文章
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2001年学术文章
@zh-cn
2001年学术文章
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2001年学术文章
@zh-my
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2001年學術文章
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name
Functional role of a conserved ...... from substitutions of Thr6.34
@nl
Functional role of a conserved ...... Thr6.34(279) with Lys and Asp.
@en
type
label
Functional role of a conserved ...... from substitutions of Thr6.34
@nl
Functional role of a conserved ...... Thr6.34(279) with Lys and Asp.
@en
prefLabel
Functional role of a conserved ...... from substitutions of Thr6.34
@nl
Functional role of a conserved ...... Thr6.34(279) with Lys and Asp.
@en
P2093
P356
P1433
P1476
Functional role of a conserved ...... Thr6.34(279) with Lys and Asp
@en
P2093
P304
13501-13509
P356
10.1021/BI010917Q
P407
P577
2001-11-01T00:00:00Z