Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice - Wikidata - awgldk - TriplyDB

Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice

Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice

http://www.wikidata.org/entity/Q42526889

about

Recent advances in understanding and managing cholestasis Combination therapy of fenofibrate and ursodeoxycholic acid in patients with primary biliary cirrhosis who respond incompletely to UDCA monotherapy: a meta-analysis Peroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme Bezafibrate stimulates canalicular localization of NBD-labeled PC in HepG2 cells by PPARalpha-mediated redistribution of ABCB4.Filling gaps in PPAR-alpha signaling through comparative nutrigenomics analysis.Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Fibrates for the treatment of cholestatic itch (FITCH): study protocol for a randomized controlled trial.Peroxisome proliferator-activated receptor α activates human multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 transcription and increases rat biliary phosphatidylcholine secretion PPARα: A Master Regulator of Bilirubin Homeostasis CNX-013-B2, a unique pan tissue acting rexinoid, modulates several nuclear receptors and controls multiple risk factors of the metabolic syndrome without risk of hypertriglyceridemia, hepatomegaly and body weight gain in animal models.Involvement of SIK3 in glucose and lipid homeostasis in mice.Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1.The mechanism of enterohepatic circulation in the formation of gallstone disease.PPAR-alpha effects on the heart and other vascular tissues.Transcription of the Human Microsomal Epoxide Hydrolase Gene (EPHX1) Is Regulated by PARP-1 and Histone H1.2. Association with Sodium-Dependent Bile Acid Transport.Stress- (and diet-) related regulation of hepatic nuclear receptors and its relevance for ABC-transporter functions.Fibrates and cholestasis Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters.TGF-β-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury Repression of hepatobiliary transporters and differential regulation of classic and alternative bile acid pathways in mice during pregnancy.Metabolomics reveals an essential role for peroxisome proliferator-activated receptor α in bile acid homeostasis.Pregnancy represses induction of efflux transporters in livers of type I diabetic mice.Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers.Nuclear receptors as therapeutic targets in cholestatic liver diseases.Regulation of bile acid and cholesterol metabolism by PPARs The Multiple Facets of ABCB4 (MDR3) Deficiency A human hepatocyte-bearing mouse: an animal model to predict drug metabolism and effectiveness in humans Targeting the ABCB4 gene to control cholesterol homeostasis.Inhibition of JNK signalling mediates PPARα-dependent protection against intrahepatic cholestasis by fenofibrate.Anticholestatic effects of bezafibrate in patients with primary biliary cirrhosis treated with ursodeoxycholic acid.Transcriptional regulation of murine Slc22a1 (Oct1) by peroxisome proliferator agonist receptor-alpha and -gamma.The UDP-glucuronosyltransferase 1A9 enzyme is a peroxisome proliferator-activated receptor alpha and gamma target gene.Alteration of canalicular transporters in a mouse model of total parenteral nutrition.PPAR Medicines and Human Disease: The ABCs of It All.Peroxisome proliferator-activated receptor alpha target genes.Secretory phospholipase A2 increases SR-BI-mediated selective uptake from HDL but not biliary cholesterol secretion.PPAR-α, a lipid-sensing transcription factor, regulates blood-brain barrier efflux transporter expression.A prospective randomized controlled study of long-term combination therapy using ursodeoxycholic acid and bezafibrate in patients with primary biliary cirrhosis and dyslipidemia.A functional classification of ABCB4 variations causing progressive familial intrahepatic cholestasis type 3.Hepatic lipid accumulation in apolipoprotein C-I-deficient mice is potentiated by cholesteryl ester transfer protein.

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P2860

Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice

http://www.wikidata.org/entity/Q42526889

description

2003 nî lūn-bûn

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年學術文章

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2003年學術文章

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2003年學術文章

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Peroxisome proliferator-activa ...... xpression and function in mice

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Peroxisome proliferator-activa ...... xpression and function in mice

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Peroxisome proliferator-activa ...... xpression and function in mice

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P1433

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P1433

Biochemical Journal

P1476

Peroxisome proliferator-activa ...... xpression and function in mice

@en

P2093

Folkert Kuipers

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Henk Wolters

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Peter L M Jansen

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Rick Havinga

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Tineke Kok

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P2860

Protein measurement with the Folin phenol reagent

Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol

Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators

Mechanism of action of fibrates on lipid and lipoprotein metabolism

A simple and sensitive assay of total serum bile acids

ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice

Fibrates induce mdr2 gene expression and biliary phospholipid secretion in the mouse

Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene

The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver

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539-547

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scholarly article

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10.1042/BJ20020981

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P433

Pt 3

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P478

369

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Vincent Walter Bloks

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2003-02-01T00:00:00Z

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12381268

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multiple drug resistance

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1223107

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