A strongly transdominant mutation in the human immunodeficiency virus type 1 gag gene defines an Achilles heel in the virus life cycle
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HIV type 1 Gag as a target for antiviral therapyThe choreography of HIV-1 proteolytic processing and virion assemblyAlkyl Amine Bevirimat Derivatives Are Potent and Broadly Active HIV-1 Maturation Inhibitors.Structure-Activity Relationships of the Human Immunodeficiency Virus Type 1 Maturation Inhibitor PF-46396Protein Interferon-Stimulated Gene 15 Conjugation Delays but Does Not Overcome Coronavirus Proliferation in a Model of Fulminant HepatitisMaturation of the HIV-1 core by a non-diffusional phase transition.In vitro protease cleavage and computer simulations reveal the HIV-1 capsid maturation pathway.Novel approaches to inhibiting HIV-1 replication.The capsid-spacer peptide 1 Gag processing intermediate is a dominant-negative inhibitor of HIV-1 maturation.Cryo electron tomography of native HIV-1 budding sites.Structural analysis of HIV-1 maturation using cryo-electron tomography.Distinct nucleic acid interaction properties of HIV-1 nucleocapsid protein precursor NCp15 explain reduced viral infectivity.The ISG15 conjugation system broadly targets newly synthesized proteins: implications for the antiviral function of ISG15.Generation of infectious feline immunodeficiency virus (FIV) encoding FIV/human immunodeficiency virus chimeric protease.Fundamental differences between the nucleic acid chaperone activities of HIV-1 nucleocapsid protein and Gag or Gag-derived proteins: biological implicationsDevelopment of a Novel Screening Strategy Designed to Discover a New Class of HIV Drugs.A sensitive assay using a native protein substrate for screening HIV-1 maturation inhibitors targeting the protease cleavage site between the matrix and capsidTargeting the HIV entry, assembly and release pathways for anti-HIV gene therapy.Lentiviral Gag assembly analyzed through the functional characterization of chimeric simian immunodeficiency viruses expressing different domains of the feline immunodeficiency virus capsid protein.ATP generation in a host cell in early-phase infection is increased by upregulation of cytochrome c oxidase activity via the p2 peptide from human immunodeficiency virus type 1 Gag.Elucidation of the Molecular Mechanism Driving Duplication of the HIV-1 PTAP Late Domain.Site-selective probing of cTAR destabilization highlights the necessary plasticity of the HIV-1 nucleocapsid protein to chaperone the first strand transfer.Integrating the HIV-1 assembly/maturation pathway.A mutant Tat protein provides strong protection from HIV-1 infection in human CD4+ T cells.Glyceraldehyde 3-phosphate dehydrogenase negatively regulates human immunodeficiency virus type 1 infection.Three residues in HIV-1 matrix contribute to protease inhibitor susceptibility and replication capacity.A Truncated Nef Peptide from SIVcpz Inhibits the Production of HIV-1 Infectious Progeny.RNA and Nucleocapsid Are Dispensable for Mature HIV-1 Capsid Assembly.The C-terminal domain of glyceraldehyde 3-phosphate dehydrogenase plays an important role in suppression of tRNALys3 packaging into human immunodeficiency virus type-1 particles.A Direct Interaction with RNA Dramatically Enhances the Catalytic Activity of the HIV-1 Protease In VitroInduced maturation of human immunodeficiency virus.BST-2 diminishes HIV-1 infectivity.Protease-Mediated Maturation of HIV: Inhibitors of Protease and the Maturation ProcessClearly different mechanisms of enhancement of short-lived Nef-mediated viral infectivity between SIV and HIV-1.A cleavage enzyme-cytometric bead array provides biochemical profiling of resistance mutations in HIV-1 Gag and protease.Patterns of conserved gp120 epitope presentation on attached HIV-1 virions.An RNA-binding compound that stabilizes the HIV-1 gRNA packaging signal structure and specifically blocks HIV-1 RNA encapsidation.Transmission genetics of drug-resistant hepatitis C virus.
P2860
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P2860
A strongly transdominant mutation in the human immunodeficiency virus type 1 gag gene defines an Achilles heel in the virus life cycle
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
A strongly transdominant mutat ...... s heel in the virus life cycle
@en
A strongly transdominant mutat ...... s heel in the virus life cycle
@nl
type
label
A strongly transdominant mutat ...... s heel in the virus life cycle
@en
A strongly transdominant mutat ...... s heel in the virus life cycle
@nl
prefLabel
A strongly transdominant mutat ...... s heel in the virus life cycle
@en
A strongly transdominant mutat ...... s heel in the virus life cycle
@nl
P2860
P356
P1433
P1476
A strongly transdominant mutat ...... s heel in the virus life cycle
@en
P2093
Janera Harris
Sook-Kyung Lee
P2860
P304
P356
10.1128/JVI.00317-09
P407
P577
2009-06-10T00:00:00Z