Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, guinea pigs, dogs, monkeys, and humans.
about
A new approach to predicting human hepatic clearance of CYP3A4 substrates using monkey pharmacokinetic data.Expressed sequence tags from cynomolgus monkey (Macaca fascicularis) liver: a systematic identification of drug-metabolizing enzymes.Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries.Binding of diverse environmental chemicals with human cytochromes P450 2A13, 2A6, and 1B1 and enzyme inhibition.Acute versus chronic alcohol consumption in acetaminophen-induced hepatotoxicity.In vitro cytochrome P450-mediated hepatic activities for five substrates in specific pathogen free chickens.Issues related to the use of canines in toxicologic pathology--issues with pharmacokinetics and metabolism.Immunochemical detection of cytochrome P450 enzymes in liver microsomes of 27 cynomolgus monkeys.Genome-based analysis of the nonhuman primate Macaca fascicularis as a model for drug safety assessmentSpontaneous and drug-induced hepatic pathology of the laboratory beagle dog, the cynomolgus macaque and the marmoset.The conduct of drug metabolism studies considered good practice (II): in vitro experimentsA Toxicologist's Guide to the Preclinical Assessment of Hepatic Microsomal Enzyme Induction.Hepatic enzyme induction: histopathology.Psychophysiological stress: a significant parameter in drug pharmacokinetics.Emerging roles for brain drug-metabolizing cytochrome P450 enzymes in neuropsychiatric conditions and responses to drugs.Pharmacokinetics cannot explain the increased effective dose requirement for morphine and midazolam in rats during their extended administration alone or in combination.Rifampin-Mediated Induction of Tamoxifen Metabolism in a Humanized PXR-CAR-CYP3A4/3A7-CYP2D6 Mouse Model.Inhibitory mechanisms of celastrol on human liver cytochrome P450 1A2, 2C19, 2D6, 2E1 and 3A4.A novel CYP2A26 identified in cynomolgus monkey liver metabolizes coumarin.Chlorzoxazone: a probe drug the metabolism of which can be used to monitor one-point blood sampling in the carbon tetrachloride-intoxicated rat.Biotransformation of flobufen enantiomers in ruminant hepatocytes and subcellular fractions.Reduction of flobufen in pig hepatocytes: effect of pig breed (domestic, wild) and castration.mRNA and protein expression of dog liver cytochromes P450 in relation to the metabolism of human CYP2C substrates.Effect of gemfibrozil on the metabolism of pitavastatin--determining the best animal model for human CYP and UGT activities.Comprehensive evaluation of liver microsomal cytochrome P450 3A (CYP3A) inhibition: comparison of cynomolgus monkey and human.The effect of the Pheroid delivery system on the in vitro metabolism and in vivo pharmacokinetics of artemisone.Characterization of cytochrome P450 (CYP3A12) induction by rifampicin in dog liver.Interlaboratory comparison of the assessment of P450 activities in human hepatic microsomal samples.Characterization of cytochrome P450-mediated drug metabolism in cats.Species differences in hepatic and intestinal metabolic activities for 43 human cytochrome P450 substrates between humans and rats or dogs.Toward reduction in animal sacrifice for drugs: molecular modeling of Macaca fascicularis P450 2C20 for virtual screening of Homo sapiens P450 2C8 substrates.Expanding biological space coverage enhances the prediction of drug adverse effects in human using in vitro activity profiles.Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: A comparative studyin vitro
P2860
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P2860
Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, guinea pigs, dogs, monkeys, and humans.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Cytochrome P450-dependent drug ...... gs, dogs, monkeys, and humans.
@en
Cytochrome P450-dependent drug ...... gs, dogs, monkeys, and humans.
@nl
type
label
Cytochrome P450-dependent drug ...... gs, dogs, monkeys, and humans.
@en
Cytochrome P450-dependent drug ...... gs, dogs, monkeys, and humans.
@nl
prefLabel
Cytochrome P450-dependent drug ...... gs, dogs, monkeys, and humans.
@en
Cytochrome P450-dependent drug ...... gs, dogs, monkeys, and humans.
@nl
P2093
P356
P1476
Cytochrome P450-dependent drug ...... gs, dogs, monkeys, and humans.
@en
P2093
P2888
P304
P356
10.1007/S002040050403
P577
1997-01-01T00:00:00Z