Structure-function relationships of omega-conotoxin GVIA. Synthesis, structure, calcium channel binding, and functional assay of alanine-substituted analogues.
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Recombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton-gated cation channelsBioactive Mimetics of Conotoxins and other Venom PeptidesRefined solution structure of omega-conotoxin GVIA: implications for calcium channel bindingOmega-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminalsSolution structure and alanine scan of a spider toxin that affects the activation of mammalian voltage-gated sodium channelsNovel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypesBinding of Ala-scanning analogs of omega-conotoxin MVIIC to N- and P/Q-type calcium channels.Role of Thr(11) in the binding of omega-conotoxin MVIIC to N-type Ca2+ channels.Structure-activity relationships of omega-conotoxins at N-type voltage-sensitive calcium channels.Binding modes of two scorpion toxins to the voltage-gated potassium channel kv1.3 revealed from molecular dynamics.Role of N-type calcium channels in autonomic neurotransmission in guinea-pig isolated left atriaCardiovascular and autonomic effects of omega-conotoxins MVIIA and CVID in conscious rabbits and isolated tissue assays.SO-3, a new O-superfamily conopeptide derived from Conus striatus, selectively inhibits N-type calcium currents in cultured hippocampal neurons.Venom peptides as a rich source of cav2.2 channel blockers.A Conus regularis conotoxin with a novel eight-cysteine framework inhibits CaV2.2 channels and displays an anti-nociceptive activityStrategies for the development of conotoxins as new therapeutic leads.Targeting voltage-gated calcium channels: developments in peptide and small-molecule inhibitors for the treatment of neuropathic pain.omega-conotoxin GVIA alters gating charge movement of N-type (CaV2.2) calcium channels.Scanning mutagenesis reveals a role for serine 189 of the heterotrimeric G-protein beta 1 subunit in the inhibition of N-type calcium channels.Site-specific effects of diselenide bridges on the oxidative folding of a cystine knot peptide, omega-selenoconotoxin GVIA.Scanning mutagenesis of a Janus-faced atracotoxin reveals a bipartite surface patch that is essential for neurotoxic function.Roles of key functional groups in omega-conotoxin GVIA synthesis, structure and functional assay of selected peptide analogues.Conotoxins as Tools to Understand the Physiological Function of Voltage-Gated Calcium (CaV) Channels.Structural analysis of free and enzyme-bound amaranth alpha-amylase inhibitor: classification within the knottin fold superfamily and analysis of its functional flexibility.Cloning and characterization of a putative inhibitor of melanization from Anopheles gambiae.Design, Synthesis and Biological Evaluation of Two Opioid Agonist and Cav 2.2 Blocker Multitarget Ligands.ω-Conotoxins GVIA, MVIIA and CVID: SAR and Clinical Potential.Molecular Engineering of Conus Peptides as Therapeutic Leads.New Conotoxin SO-3 Targeting N-type Voltage-Sensitive Calcium Channels.Function and solution structure of Huwentoxin-X, a specific blocker of N-type calcium channels, from the Chinese bird spider Ornithoctonus huwena.Physiological and biochemical analysis of L. tredecimguttatus venom collected by electrical stimulation.Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides
P2860
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P2860
Structure-function relationships of omega-conotoxin GVIA. Synthesis, structure, calcium channel binding, and functional assay of alanine-substituted analogues.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Structure-function relationshi ...... alanine-substituted analogues.
@en
Structure-function relationshi ...... alanine-substituted analogues.
@nl
type
label
Structure-function relationshi ...... alanine-substituted analogues.
@en
Structure-function relationshi ...... alanine-substituted analogues.
@nl
prefLabel
Structure-function relationshi ...... alanine-substituted analogues.
@en
Structure-function relationshi ...... alanine-substituted analogues.
@nl
P2093
P2860
P50
P356
P1476
Structure-function relationshi ...... alanine-substituted analogues
@en
P2093
P K Pallaghy
R S Norton
S L Whorlow
P2860
P304
12014-12023
P356
10.1074/JBC.272.18.12014
P407
P577
1997-05-01T00:00:00Z