Torsade de pointes with an antihistamine metabolite: potassium channel blockade with desmethylastemizole.
about
Involvement of multiple human cytochromes P450 in the liver microsomal metabolism of astemizole and a comparison with terfenadineDifferences in action potential and early afterdepolarization properties in LQT2 and LQT3 models of long QT syndromeVitamin K modulates cardiac action potential by blocking sodium and potassium ion channels.Iatrogenic QT Abnormalities and Fatal Arrhythmias: Mechanisms and Clinical SignificanceThe metabolism of antihistamines and drug interactions: the role of cytochrome P450 enzymes.Cardiac ion channels and antihistamines: possible mechanisms of cardiotoxicity.The metabolic profile of second-generation antihistamines.H1-antihistamines: inverse agonism, anti-inflammatory actions and cardiac effects.Both T- and L-type Ca2+ channels can contribute to excitation-contraction coupling in cardiac Purkinje cells.Drug-induced long QT syndromePrinciples in pharmacogenetics.The significance of QT interval in drug development.Mechanistic basis of adverse drug reactions: the perils of inappropriate dose schedules.Drug-induced Inhibition and Trafficking Disruption of ion Channels: Pathogenesis of QT Abnormalities and Drug-induced Fatal Arrhythmias.New substituted benzimidazole derivatives: a patent review (2010 - 2012).New substituted benzimidazole derivatives: a patent review (2013 - 2014).Reckless administration of QT interval-prolonging agents in elderly patients with drug-induced torsade de pointes.Evidence for the hERG Liability of Antihistamines, Antipsychotics, and Anti-Infective Agents: A Systematic Literature Review From the ARITMO Project.Therapeutic advantages of third generation antihistamines.ICH E14 Q&A(R2) document: commentary on the further updated recommendations on thorough QT studies.Simultaneous gene expression signature of heart and peripheral blood mononuclear cells in astemizole-treated rats.Sildenafil citrate does not affect QT intervals and QT dispersion: an important observation for drug safety.Antihistamines in severe/chronic rhinitis.Electrophysiological effects of cetirizine, astemizole and D-sotalol in a canine model of long QT syndrome.Drug‐induced QT interval prolongation: regulatory perspectives and drug developmentInternational Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment
P2860
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P2860
Torsade de pointes with an antihistamine metabolite: potassium channel blockade with desmethylastemizole.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Torsade de pointes with an ant ...... kade with desmethylastemizole.
@en
Torsade de pointes with an ant ...... kade with desmethylastemizole.
@nl
type
label
Torsade de pointes with an ant ...... kade with desmethylastemizole.
@en
Torsade de pointes with an ant ...... kade with desmethylastemizole.
@nl
prefLabel
Torsade de pointes with an ant ...... kade with desmethylastemizole.
@en
Torsade de pointes with an ant ...... kade with desmethylastemizole.
@nl
P2093
P1476
Torsade de pointes with an ant ...... kade with desmethylastemizole.
@en
P2093
P304
P356
10.1016/S0735-1097(96)00352-X
P407
P577
1996-11-01T00:00:00Z