Activation of specific RXR heterodimers by an antagonist of RXR homodimers.
about
Role of Nuclear Receptors in Central Nervous System Development and Associated DiseasesThe structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12Modulators of the structural dynamics of the retinoid X receptor to reveal receptor functionThe “Phantom Effect” of the Rexinoid LG100754: Structural and Functional InsightsRetinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiationInduction of the fatty acid transport protein 1 and acyl-CoA synthase genes by dimer-selective rexinoids suggests that the peroxisome proliferator-activated receptor-retinoid X receptor heterodimer is their molecular targetHeterodimeric interaction between retinoid X receptor alpha and orphan nuclear receptor OR1 reveals dimerization-induced activation as a novel mechanism of nuclear receptor activationRetinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling.Metabolism to a response pathway selective retinoid ligand during axial pattern formation.Rexinoid bexarotene modulates triglyceride but not cholesterol metabolism via gene-specific permissivity of the RXR/LXR heterodimer in the liver.The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosisA mutation mimicking ligand-induced conformational change yields a constitutive RXR that senses allosteric effects in heterodimers.Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression.A structural model of the constitutive androstane receptor defines novel interactions that mediate ligand-independent activityIn vivo activation of PPAR target genes by RXR homodimers.Organotins are potent activators of PPARγ and adipocyte differentiation in bone marrow multipotent mesenchymal stromal cellsNuclear receptors as therapeutic targets for Alzheimer's diseaseNovel peroxisome proliferator-activated receptor ligands for Type 2 diabetes and the metabolic syndrome.Analysis of differential secondary effects of novel rexinoids: select rexinoid X receptor ligands demonstrate differentiated side effect profiles.Therapeutic potential of retinoid x receptor modulators for the treatment of the metabolic syndromeCoexpression of nuclear receptor partners increases their solubility and biological activities.Chemoprevention of lung cancer: concepts and strategies.Inhibition of trans-retinoic acid-resistant human breast cancer cell growth by retinoid X receptor-selective retinoidsPPAR γ Networks in Cell Signaling: Update and Impact of Cyclic Phosphatidic Acid.Cooperative activation of gene expression by agonists and antagonists mediated by estrogen receptor heteroligand dimer complexes.Retinoid X receptor and peroxisome proliferator-activated receptor-gamma agonists cooperate to inhibit matrix metalloproteinase gene expression.Modeling, synthesis, and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydroThe multi-faceted role of retinoid X receptor in bone remodeling.Retinoid X receptor (RXR) agonist-induced activation of dominant-negative RXR-retinoic acid receptor alpha403 heterodimers is developmentally regulated during myeloid differentiationLigand-dependent degradation of retinoid X receptors does not require transcriptional activity or coactivator interactions.Transactivation by retinoid X receptor-peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimers: intermolecular synergy requires only the PPARgamma hormone-dependent activation functionResearch resource: transcriptome profiling of genes regulated by RXR and its permissive and nonpermissive partners in differentiating monocyte-derived dendritic cells.Functional evidence for retinoid X receptor (RXR) as a nonsilent partner in the thyroid hormone receptor/RXR heterodimer.Involvement of NF-kappaB subunit p65 and retinoic acid receptors, RARalpha and RXRalpha, in transcriptional regulation of the human GnRH II gene.A permissive retinoid X receptor/thyroid hormone receptor heterodimer allows stimulation of prolactin gene transcription by thyroid hormone and 9-cis-retinoic acid.Synthetic retinoids: structure-activity relationships.Retinoid signalling and gene expression in neuroblastoma cells: RXR agonist and antagonist effects on CRABP-II and RARbeta expression.Identification of gene-selective modulators of the bile acid receptor FXR.Novel roles of retinoid X receptor (RXR) and RXR ligand in dynamically modulating the activity of the thyroid hormone receptor/RXR heterodimer.Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies.
P2860
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P2860
Activation of specific RXR heterodimers by an antagonist of RXR homodimers.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Activation of specific RXR heterodimers by an antagonist of RXR homodimers.
@en
Activation of specific RXR heterodimers by an antagonist of RXR homodimers.
@nl
type
label
Activation of specific RXR heterodimers by an antagonist of RXR homodimers.
@en
Activation of specific RXR heterodimers by an antagonist of RXR homodimers.
@nl
prefLabel
Activation of specific RXR heterodimers by an antagonist of RXR homodimers.
@en
Activation of specific RXR heterodimers by an antagonist of RXR homodimers.
@nl
P2093
P356
P1433
P1476
Activation of specific RXR heterodimers by an antagonist of RXR homodimers.
@en
P2093
Croston GE
Dardashti LJ
Mukherjee R
Schulman IG
P2888
P304
P356
10.1038/383450A0
P407
P577
1996-10-01T00:00:00Z
P6179
1051667326