Activation of specific RXR heterodimers by an antagonist of RXR homodimers. - Wikidata - awgldk - TriplyDB

Activation of specific RXR heterodimers by an antagonist of RXR homodimers.

Activation of specific RXR heterodimers by an antagonist of RXR homodimers.

http://www.wikidata.org/entity/Q42553589

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Role of Nuclear Receptors in Central Nervous System Development and Associated Diseases The structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12 Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function The “Phantom Effect” of the Rexinoid LG100754: Structural and Functional Insights Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation Induction of the fatty acid transport protein 1 and acyl-CoA synthase genes by dimer-selective rexinoids suggests that the peroxisome proliferator-activated receptor-retinoid X receptor heterodimer is their molecular target Heterodimeric interaction between retinoid X receptor alpha and orphan nuclear receptor OR1 reveals dimerization-induced activation as a novel mechanism of nuclear receptor activation Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling.Metabolism to a response pathway selective retinoid ligand during axial pattern formation.Rexinoid bexarotene modulates triglyceride but not cholesterol metabolism via gene-specific permissivity of the RXR/LXR heterodimer in the liver.The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis A mutation mimicking ligand-induced conformational change yields a constitutive RXR that senses allosteric effects in heterodimers.Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression.A structural model of the constitutive androstane receptor defines novel interactions that mediate ligand-independent activity In vivo activation of PPAR target genes by RXR homodimers.Organotins are potent activators of PPARγ and adipocyte differentiation in bone marrow multipotent mesenchymal stromal cells Nuclear receptors as therapeutic targets for Alzheimer's disease Novel peroxisome proliferator-activated receptor ligands for Type 2 diabetes and the metabolic syndrome.Analysis of differential secondary effects of novel rexinoids: select rexinoid X receptor ligands demonstrate differentiated side effect profiles.Therapeutic potential of retinoid x receptor modulators for the treatment of the metabolic syndrome Coexpression of nuclear receptor partners increases their solubility and biological activities.Chemoprevention of lung cancer: concepts and strategies.Inhibition of trans-retinoic acid-resistant human breast cancer cell growth by retinoid X receptor-selective retinoids PPAR γ Networks in Cell Signaling: Update and Impact of Cyclic Phosphatidic Acid.Cooperative activation of gene expression by agonists and antagonists mediated by estrogen receptor heteroligand dimer complexes.Retinoid X receptor and peroxisome proliferator-activated receptor-gamma agonists cooperate to inhibit matrix metalloproteinase gene expression.Modeling, synthesis, and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydro The multi-faceted role of retinoid X receptor in bone remodeling.Retinoid X receptor (RXR) agonist-induced activation of dominant-negative RXR-retinoic acid receptor alpha403 heterodimers is developmentally regulated during myeloid differentiation Ligand-dependent degradation of retinoid X receptors does not require transcriptional activity or coactivator interactions.Transactivation by retinoid X receptor-peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimers: intermolecular synergy requires only the PPARgamma hormone-dependent activation function Research resource: transcriptome profiling of genes regulated by RXR and its permissive and nonpermissive partners in differentiating monocyte-derived dendritic cells.Functional evidence for retinoid X receptor (RXR) as a nonsilent partner in the thyroid hormone receptor/RXR heterodimer.Involvement of NF-kappaB subunit p65 and retinoic acid receptors, RARalpha and RXRalpha, in transcriptional regulation of the human GnRH II gene.A permissive retinoid X receptor/thyroid hormone receptor heterodimer allows stimulation of prolactin gene transcription by thyroid hormone and 9-cis-retinoic acid.Synthetic retinoids: structure-activity relationships.Retinoid signalling and gene expression in neuroblastoma cells: RXR agonist and antagonist effects on CRABP-II and RARbeta expression.Identification of gene-selective modulators of the bile acid receptor FXR.Novel roles of retinoid X receptor (RXR) and RXR ligand in dynamically modulating the activity of the thyroid hormone receptor/RXR heterodimer.Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies.

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P2860

Activation of specific RXR heterodimers by an antagonist of RXR homodimers.

http://www.wikidata.org/entity/Q42553589

description

1996 nî lūn-bûn

@nan

1996年の論文

@ja

1996年論文

@yue

1996年論文

@zh-hant

1996年論文

@zh-hk

1996年論文

@zh-mo

1996年論文

@zh-tw

1996年论文

@wuu

1996年论文

@zh

1996年论文

@zh-cn

name

Activation of specific RXR heterodimers by an antagonist of RXR homodimers.

@en

Activation of specific RXR heterodimers by an antagonist of RXR homodimers.

@nl

type

label

Activation of specific RXR heterodimers by an antagonist of RXR homodimers.

@en

Activation of specific RXR heterodimers by an antagonist of RXR homodimers.

@nl

prefLabel

Activation of specific RXR heterodimers by an antagonist of RXR homodimers.

@en

Activation of specific RXR heterodimers by an antagonist of RXR homodimers.

@nl

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Activation of specific RXR heterodimers by an antagonist of RXR homodimers.

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P2093

Croston GE

http://www.w3.org/2001/XMLSchema#string

Dardashti LJ

http://www.w3.org/2001/XMLSchema#string

Evans RM

http://www.w3.org/2001/XMLSchema#string

Heyman RA

http://www.w3.org/2001/XMLSchema#string

Koch SS

http://www.w3.org/2001/XMLSchema#string

Lala DS

http://www.w3.org/2001/XMLSchema#string

Mukherjee R

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Nadzan AM

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Schulman IG

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450-453

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scholarly article

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10.1038/383450A0

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P433

6599

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383

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1996-10-01T00:00:00Z

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1051667326

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8837780

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