S. pombe btn1, the orthologue of the Batten disease gene CLN3, is required for vacuole protein sorting of Cpy1p and Golgi exit of Vps10p.
about
Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartmentsThe role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sortingCLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent eventsLarge-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous systemThe juvenile Batten disease protein, CLN3, and its role in regulating anterograde and retrograde post-Golgi trafficking.Osmotic stress changes the expression and subcellular localization of the Batten disease protein CLN3.Fully hydrated yeast cells imaged with electron microscopy.The yeast Batten disease orthologue Btn1 controls endosome-Golgi retrograde transport via SNARE assembly.BTN1, the Saccharomyces cerevisiae homolog to the human Batten disease gene, is involved in phospholipid distribution.Photoreceptor phagosome processing defects and disturbed autophagy in retinal pigment epithelium of Cln3Δex1-6 mice modelling juvenile neuronal ceroid lipofuscinosis (Batten disease).Osmoregulation of ceroid neuronal lipofuscinosis type 3 in the renal medullaVision loss in juvenile neuronal ceroid lipofuscinosis (CLN3 disease)CLN3 loss disturbs membrane microdomain properties and protein transport in brain endothelial cells.Regulation of Ras localization and cell transformation by evolutionarily conserved palmitoyltransferasesHuman iPSC models of neuronal ceroid lipofuscinosis capture distinct effects of TPP1 and CLN3 mutations on the endocytic pathwayNCLs and ER: A stressful relationship.pH-dependent localization of Btn1p in the yeast model for Batten diseaseA central role for TOR signalling in a yeast model for juvenile CLN3 diseasein vivo localization of the neuronal ceroid lipofuscinosis proteins, CLN3 and CLN7, at endogenous expression levelsLack of specificity of antibodies raised against CLN3, the lysosomal/endosomal transmembrane protein mutated in juvenile Batten disease.Modulating membrane fluidity corrects Batten disease phenotypes in vitro and in vivo.
P2860
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P2860
S. pombe btn1, the orthologue of the Batten disease gene CLN3, is required for vacuole protein sorting of Cpy1p and Golgi exit of Vps10p.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
S. pombe btn1, the orthologue ...... py1p and Golgi exit of Vps10p.
@en
S. pombe btn1, the orthologue ...... py1p and Golgi exit of Vps10p.
@nl
type
label
S. pombe btn1, the orthologue ...... py1p and Golgi exit of Vps10p.
@en
S. pombe btn1, the orthologue ...... py1p and Golgi exit of Vps10p.
@nl
prefLabel
S. pombe btn1, the orthologue ...... py1p and Golgi exit of Vps10p.
@en
S. pombe btn1, the orthologue ...... py1p and Golgi exit of Vps10p.
@nl
P2860
P356
P1476
S. pombe btn1, the orthologue ...... py1p and Golgi exit of Vps10p.
@en
P2093
Sandra Codlin
P2860
P304
P356
10.1242/JCS.038323
P407
P50
P577
2009-03-19T00:00:00Z