The Smc5-Smc6 DNA repair complex. bridging of the Smc5-Smc6 heads by the KLEISIN, Nse4, and non-Kleisin subunits.
about
Interactions between the Nse3 and Nse4 components of the SMC5-6 complex identify evolutionarily conserved interactions between MAGE and EID FamiliesIdentification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complexSmc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisionsInterplay between the Smc5/6 complex and the Mph1 helicase in recombinational repairFlexibility in the order of action and in the enzymology of the nuclease, polymerases, and ligase of vertebrate non-homologous DNA end joining: relevance to cancer, aging, and the immune systemCharacterisation of the SUMO-like domains of Schizosaccharomyces pombe Rad60Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung diseaseH2A.Z-dependent regulation of cohesin dynamics on chromosome armsIn Favor of Establishment: Regulation of Chromatid Cohesion in PlantsNon-SMC elements 1 and 3 are required for early embryo and seedling development in Arabidopsis.Cruciform structures are a common DNA feature important for regulating biological processes.The maintenance of chromosome structure: positioning and functioning of SMC complexes.The Smc5/Smc6/MAGE complex confers resistance to caffeine and genotoxic stress in Drosophila melanogaster.The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complexATPase-dependent control of the Mms21 SUMO ligase during DNA repair.Nse1-dependent recruitment of Smc5/6 to lesion-containing loci contributes to the repair defects of mutant complexesNSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activityChromatin association of the SMC5/6 complex is dependent on binding of its NSE3 subunit to DNA.Nse1 RING-like domain supports functions of the Smc5-Smc6 holocomplex in genome stability.The Nse2/Mms21 SUMO ligase of the Smc5/6 complex in the maintenance of genome stability.The SMC complexes, DNA and chromosome topology: right or knot?Functional interplay between cohesin and Smc5/6 complexes.Purification, crystallization and preliminary X-ray crystallographic studies of the complex between Smc5 and the SUMO E3 ligase Mms21.Resolving complex chromosome structures during meiosis: versatile deployment of Smc5/6.SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes.Length-dependent binding of human XLF to DNA and stimulation of XRCC4.DNA ligase IV activity.Nse1 and Nse4, subunits of the Smc5-Smc6 complex, are involved in Dictyostelium development upon starvation.Smc5/6 Is a Telomere-Associated Complex that Regulates Sir4 Binding and TPE.Localization of Smc5/6 to centromeres and telomeres requires heterochromatin and SUMO, respectively.Non-Smc element 5 (Nse5) of the Smc5/6 complex interacts with SUMO pathway components.Analysis of the Nse3/MAGE-binding domain of the Nse4/EID family proteins.Smc5-Smc6-dependent removal of cohesin from mitotic chromosomes.Architecture of the Smc5/6 Complex of Saccharomyces cerevisiae Reveals a Unique Interaction between the Nse5-6 Subcomplex and the Hinge Regions of Smc5 and Smc6DNA Entry into and Exit out of the Cohesin Ring by an Interlocking Gate Mechanism.The Arabidopsis CAP-D proteins are required for correct chromatin organisation, growth and fertility.The STRUCTURAL MAINTENANCE OF CHROMOSOMES 5/6 complex promotes sister chromatid alignment and homologous recombination after DNA damage in Arabidopsis thaliana.Interaction of the Saccharomyces cerevisiae RING-domain protein Nse1 with Nse3 and the Smc5/6 complex is required for chromosome replication and stability.Scaffolding for Repair: Understanding Molecular Functions of the SMC5/6 Complex.
P2860
Q24294572-954523BB-6D7C-4259-9340-B70346433305Q24304051-71DD6117-F19C-41D5-BA94-57E827ED9A1AQ27317410-24232264-1B63-4CA2-A21C-DC4B1D6CA1DEQ27933139-AB415CBB-F627-405B-A672-3A29956ABD33Q28261381-56BEAAD2-E7D0-4D53-94CA-675D90ABD289Q28475600-50EDD3EB-51A0-4DC7-A124-A21B4147E3A6Q28975769-6FC672D8-47B7-4019-A487-3C548CB0040DQ30424283-FB1A1821-5E5A-4CE1-9FD5-AFBC69CF4EF1Q33716096-942085B9-68CB-4995-BE2D-BCB7F82166FFQ33719572-78B24C4B-20E2-4FC5-80B7-51FCCC2ADD43Q33982201-521C1295-0691-4E11-A8D3-C2D5CDF7D13AQ34434467-85826C03-9EEA-41A6-9E6A-6A7E62F4A1B4Q34652479-DCB35B29-B326-49E2-BDB8-71DDC36522F0Q35543268-EEBE5E48-A4E0-492A-92FC-49894A18C3E5Q35575863-4A607825-B26B-4CDB-9917-CFD6088312BAQ35579830-BF7A3315-E70E-46FC-B280-E3D13653D9B9Q36270944-E0CC02D5-D11D-49A2-ABFD-EB18B23D05A2Q36588869-73E479E3-2EA5-46A6-9B61-5A42DA201FF1Q36914240-9286DA9D-1CD8-4E3C-AD10-7184EC8136A5Q37873070-045CAD8C-966D-4C5F-A7D3-D9A7815EC429Q37933389-288AE030-EFCA-423B-BF59-4AE95A177956Q38224980-4B222153-D412-4948-861A-D5CE81A4322FQ38351746-2F106B05-94ED-40AD-BA99-B6A530092BAEQ38462736-50856AE8-C431-48DD-8BE3-DD90D2EE8940Q38902484-CB4B270D-7BCD-4B74-B3C4-E8C869C59C34Q40167736-F37F8015-B99F-4674-B594-C6D7C79C00F1Q40876755-3956CFE6-3A89-40D6-96A1-6FAE91365867Q40957649-4CBCBC79-4653-45DC-9060-F39CDDBF1736Q41807702-D0C0C5FC-43AF-47B8-9B63-D7D481F9F3BAQ41898662-830EC8B5-C614-4E20-BDA6-F66711B1D4ACQ41954063-0C856758-EAA1-456C-9415-9F3D88678C08Q42065819-3E082B67-7157-45ED-9B52-8765B7290543Q42094944-D01F9DA7-D238-4F98-BA06-EB58FE80073EQ42673051-2420FC5E-5B38-4493-8251-461F240E9EAEQ43480848-5F422099-42D0-4731-A065-D840B7BC913AQ44997290-662EF43E-D03E-4BCA-9535-698D1391E947Q47422734-701E0EAD-82E3-4A0F-A27A-CBDB7AE72DAEQ48253217-03FA8F12-1DE7-4F79-AE3E-194F07B049EE
P2860
The Smc5-Smc6 DNA repair complex. bridging of the Smc5-Smc6 heads by the KLEISIN, Nse4, and non-Kleisin subunits.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
The Smc5-Smc6 DNA repair compl ...... se4, and non-Kleisin subunits.
@en
The Smc5-Smc6 DNA repair compl ...... se4, and non-Kleisin subunits.
@nl
type
label
The Smc5-Smc6 DNA repair compl ...... se4, and non-Kleisin subunits.
@en
The Smc5-Smc6 DNA repair compl ...... se4, and non-Kleisin subunits.
@nl
prefLabel
The Smc5-Smc6 DNA repair compl ...... se4, and non-Kleisin subunits.
@en
The Smc5-Smc6 DNA repair compl ...... se4, and non-Kleisin subunits.
@nl
P2093
P2860
P356
P1476
The Smc5-Smc6 DNA repair compl ...... se4, and non-Kleisin subunits.
@en
P2093
Aidan J Doherty
Alan R Lehmann
Susanne Vidot
P2860
P304
36952-36959
P356
10.1074/JBC.M608004200
P407
P50
P577
2006-09-27T00:00:00Z