The tallysomycin biosynthetic gene cluster from Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insights into the biosynthesis of the bleomycin family of antitumor antibiotics.
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Radical SAM-mediated methylation reactionsRadical-mediated enzymatic methylation: a tale of two SAMSA hybrid NRPS-PKS gene cluster related to the bleomycin family of antitumor antibiotics in Alteromonas macleodii strainsCharacterization of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus unveiling new insights into dialkylmaleic anhydride and polyketide biosynthesis.Metagenomic screening for bleomycin resistance genesThe biosynthetic gene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridis ATCC 21892.Origin and evolution of peptide-modifying dioxygenases and identification of the wybutosine hydroxylase/hydroperoxidase.Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892BlmB and TlmB provide resistance to the bleomycin family of antitumor antibiotics by N-acetylating metal-free bleomycin, tallysomycin, phleomycin, and zorbamycin.Comparative analysis of the biosynthetic gene clusters and pathways for three structurally related antitumor antibiotics: bleomycin, tallysomycin, and zorbamycin.Functional characterization of tlmH in Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insight into tallysomycin biosynthesis and affording a novel bleomycin analogNonribosomal peptide synthetases involved in the production of medically relevant natural products.Characterization of LnmO as a pathway-specific Crp/Fnr-type positive regulator for leinamycin biosynthesis in Streptomyces atroolivaceus and its application for titer improvement.Genomes to natural products PRediction Informatics for Secondary Metabolomes (PRISM)In vivo manipulation of the bleomycin biosynthetic gene cluster in Streptomyces verticillus ATCC15003 revealing new insights into its biosynthetic pathway.Glycopeptide antitumor antibiotic zorbamycin from Streptomyces flavoviridis ATCC 21892: strain improvement and structure elucidationFunctional characterization of tlmK unveiling unstable carbinolamide intermediates in the tallysomycin biosynthetic pathway.Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework.Radical S-adenosylmethionine enzymes.Engineered production and evaluation of 6'-deoxy-tallysomycin H-1 revealing new insights into the structure-activity relationship of the anticancer drug bleomycin.Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.A designer bleomycin with significantly improved DNA cleavage activity.A novel application of radiomimetic compounds as antibiotic drugs.Peroxiredoxin 2 specifically regulates the oxidative and metabolic stress response of human metastatic breast cancer cells in lungs.Isolation and characterization of two putative cytokinin oxidase genes related to grain number per spike phenotype in wheat.MbtH homology codes to identify gifted microbes for genome mining.
P2860
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P2860
The tallysomycin biosynthetic gene cluster from Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insights into the biosynthesis of the bleomycin family of antitumor antibiotics.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
The tallysomycin biosynthetic ...... mily of antitumor antibiotics.
@en
The tallysomycin biosynthetic ...... mily of antitumor antibiotics.
@nl
type
label
The tallysomycin biosynthetic ...... mily of antitumor antibiotics.
@en
The tallysomycin biosynthetic ...... mily of antitumor antibiotics.
@nl
prefLabel
The tallysomycin biosynthetic ...... mily of antitumor antibiotics.
@en
The tallysomycin biosynthetic ...... mily of antitumor antibiotics.
@nl
P2093
P2860
P356
P1433
P1476
The tallysomycin biosynthetic ...... mily of antitumor antibiotics.
@en
P2093
Evelyn Wendt-Pienkowski
Guodong Zhang
Jane M Coughlin
Liyan Wang
Meifeng Tao
Nicholas P George
P2860
P356
10.1039/B615284H
P577
2006-11-28T00:00:00Z