Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα
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Immune dysregulation and cognitive vulnerability in the aging brain: Interactions of microglia, IL-1β, BDNF and synaptic plasticityAPOE-modulated Aβ-induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspectiveDexamethasone rescues neurovascular unit integrity from cell damage caused by systemic administration of shiga toxin 2 and lipopolysaccharide in mice motor cortexGrowth factors in synaptic function.Target engagement analysis and link to pharmacodynamic endpoint for a novel class of CNS-penetrant and efficacious p38α MAPK inhibitors.The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanismThe emerging role of autoimmunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/cfs).Deficiency in p38β MAPK fails to inhibit cytokine production or protect neurons against inflammatory insult in in vitro and in vivo mouse models.Trimethyltin-Induced Microglial Activation via NADPH Oxidase and MAPKs Pathway in BV-2 Microglial Cells.Role of MK2 signaling pathway in the chronic compression of cervical spinal cordThe p38α MAPK regulates microglial responsiveness to diffuse traumatic brain injury.Evidence of neurodegeneration in autism spectrum disorderSelective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology.Structure of Crenezumab Complex with Aβ Shows Loss of β-Hairpin.Clinically relevant intronic splicing enhancer mutation in myelin proteolipid protein leads to progressive microglia and astrocyte activation in white and gray matter regions of the brainEndogenous recovery after brain damage: molecular mechanisms that balance neuronal life/death fate.Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes.Molecular Anti-inflammatory Mechanisms of Retinoids and Carotenoids in Alzheimer's Disease: a Review of Current Evidence.Glial Cell Line-Derived Neurotrophic Factor Family Members Reduce Microglial Activation via Inhibiting p38MAPKs-Mediated Inflammatory ResponsesSterile Neuroinflammation and Strategies for Therapeutic InterventionQuantitative proteomic analysis reveals that lipopolysaccharide induces mitogen-activated protein kinase-dependent activation in human microglial cells.Individual Cytokines Modulate the Neurological Symptoms of ATM Deficiency in a Region Specific Manner(1,2,3)Synthetic phosphorylation of p38α recapitulates protein kinase activityEarly stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology.Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model.Inhibition of neuronal p38α, but not p38β MAPK, provides neuroprotection against three different neurotoxic insults.Antimalarial Drug Artemether Inhibits Neuroinflammation in BV2 Microglia Through Nrf2-Dependent Mechanisms.p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1.The Anti-inflammatory Effects of 4-((5-Bromo-3-chloro-2-hydroxybenzyl) amino)-2-hydroxybenzoic Acid in Lipopolysaccharide-Activated Primary Microglial Cells.Protective Effect of Lupeol Against Lipopolysaccharide-Induced Neuroinflammation via the p38/c-Jun N-Terminal Kinase Pathway in the Adult Mouse Brain.Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility.ABBY: A phase 2 randomized trial of crenezumab in mild to moderate Alzheimer disease.An isoform-selective p38α mitogen-activated protein kinase inhibitor rescues early entorhinal cortex dysfunctions in a mouse model of Alzheimer's disease
P2860
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P2860
Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Microglial p38α MAPK is critic ...... ugh a mechanism involving TNFα
@en
Microglial p38α MAPK is critic ...... ugh a mechanism involving TNFα
@nl
type
label
Microglial p38α MAPK is critic ...... ugh a mechanism involving TNFα
@en
Microglial p38α MAPK is critic ...... ugh a mechanism involving TNFα
@nl
prefLabel
Microglial p38α MAPK is critic ...... ugh a mechanism involving TNFα
@en
Microglial p38α MAPK is critic ...... ugh a mechanism involving TNFα
@nl
P2860
P356
P1476
Microglial p38α MAPK is critic ...... ugh a mechanism involving TNFα
@en
P2093
Linda J Van Eldik
P2860
P2888
P356
10.1186/1750-1326-6-84
P577
2011-12-20T00:00:00Z
P5875
P6179
1027336562