Late-stage [(18)F]Fluorination: New Solutions to Old Problems
about
Methods to Increase the Metabolic Stability of (18)F-RadiotracersRadiochemistry, PET Imaging, and the Internet of Chemical ThingsTargeted fluorination with the fluoride ion by manganese-catalyzed decarboxylation.Titania-catalyzed radiofluorination of tosylated precursors in highly aqueous medium.Total Radiosynthesis: Thinking outside "the box"Palladium-catalyzed enantioselective 1,1-fluoroarylation of aminoalkenes.Difluorocarbene-Derived Trifluoromethylthiolation and [(18)F]Trifluoromethylthiolation of Aliphatic ElectrophilesIodonium ylide-mediated radiofluorination of 18F-FPEB and validation for human useBeyond ferryl-mediated hydroxylation: 40 years of the rebound mechanism and C-H activation.Fluorine-18 patents (2009-2015). Part 1: novel radiotracers.Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging.Hypervalent iodine(iii) fluorinations of alkenes and diazo compounds: new opportunities in fluorination chemistry.Fluorination methods for drug discovery and development.Fluorine-18 patents (2009-2015). Part 2: new radiochemistry.Fluorine-18 labelled building blocks for PET tracer synthesis.Sulfonium salts as leaving groups for aromatic labelling of drug-like small molecules with fluorine-18.Synthesis of (18) F-Difluoromethylarenes from Aryl (Pseudo) HalidesCu-Mediated C-H 18F-Fluorination of Electron-Rich (Hetero)arenesCopper-Mediated Radiofluorination of Arylstannanes with [18F]KF.Radiosynthesis and preliminary PET evaluation of (18)F-labeled 2-(1-(3-fluorophenyl)-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile for imaging AMPA receptors.Divergent reactivities in fluoronation of allylic alcohols: synthesis of Z-fluoroalkenes via carbon-carbon bond cleavage.Efficient Pathway for the Preparation of Aryl(isoquinoline)iodonium(III) Salts and Synthesis of Radiofluorinated Isoquinolines.Mechanistic Studies and Radiofluorination of Structurally Diverse Pharmaceuticals with Spirocyclic Iodonium(III) Ylides.Catalytic Nucleophilic Fluorination of Secondary and Tertiary Propargylic Electrophiles with a Copper-N-Heterocyclic Carbene ComplexDevelopment of Customized [18F]Fluoride Elution Techniques for the Enhancement of Copper-Mediated Late-Stage Radiofluorination.Moving Metal-Mediated (18)F-Fluorination from Concept to Clinic.Synthesis of [18F]Arenes via the Copper-Mediated [18F]Fluorination of Boronic Acids.Facile room temperature synthesis of fluorine-18 labeled fluoronicotinic acid-2,3,5,6-tetrafluorophenyl ester without azeotropic drying of fluorine-18.Metal-free 18F-labeling of aryl-CF2H via nucleophilic radiofluorination and oxidative C-H activation.A catalytic fluoride-rebound mechanism for C(sp3)-CF3 bond formation.Synthesis of [18 F]Fluoroarenes by Nucleophilic Radiofluorination of N-Arylsydnones.Regioselective decarboxylative addition of malonic acid and its mono(thio)esters to 4-trifluoromethylpyrimidin-2(1H)-ones.Rapid Iododeboronation with and without Gold Catalysis: Application to Radiolabelling of Arenes.Organocatalyst-assisted Ar-18F bond formation: a universal procedure for direct aromatic radiofluorination.Hydrogen Bonding: Regulator for Nucleophilic Fluorination.Alcohol-Enhanced Cu-Mediated Radiofluorination.Copper-mediated aromatic radiofluorination revisited: efficient production of PET tracers on a preparative scale.Green approaches to late-stage fluorination: radiosyntheses of (18)F-labelled radiopharmaceuticals in ethanol and water.Silver-promoted (radio)fluorination of unsaturated carbamates via a radical process.Organomediated Enantioselective (18)F Fluorination for PET Applications.
P2860
Q26781407-562A73E7-E480-45A4-A0B5-377A362A2FCDQ28069182-A00F7AA5-13D2-4B78-B61A-BA085082282DQ34465519-9B9F7A19-830E-4E69-9E7F-8425CF952FC0Q35797216-9926D64F-A705-4217-8048-8CDF8952FE91Q36100908-485DA022-FA2E-4770-AA87-FE483E45B4A4Q36147885-CFD12A18-0A0B-450B-8B2D-B2827EB7E2F0Q36407430-0C6530A6-2E3B-4160-95E5-D16EE3A454C0Q36930894-92D6750A-2907-4508-B586-16ACEDCC93CAQ37699790-CA019ECB-2ED7-42EC-ACB5-41230E62D128Q38670162-2475B019-40BB-4516-AE3C-31F00D04E20AQ38810544-27B386AF-4436-468D-9B87-E3CFF939929FQ38896999-F029E9F8-ABC6-4369-8A8A-FD3E5B4D4BBBQ38933998-3D130CF8-3954-48A2-A1F8-74F0E2854214Q38950052-5E7664FD-F3FD-4AAE-8611-743DBD1EC42EQ39369099-085739C9-D569-40BC-B574-48D22CB77F72Q39830736-1A72AEAF-D99B-4B62-9F14-DF3D628B0972Q39978269-AACB83E5-5F08-4C5D-A8DA-DCC67389DE6FQ41110557-CE9F9B34-70A9-478E-B49D-BBA75AE0E0DDQ41569105-F530B462-75CB-413D-B871-3C29A4D5ACCCQ41634484-C92EDC5C-C039-48BF-9663-686424155133Q41664519-E106E980-D74A-4D98-B1A6-BC4F81ED13D5Q41719499-1E2D3BF3-924E-4A78-A16E-3DE8FE45CA44Q41741654-865171B1-67FC-4916-9B7E-13B609955CF2Q42152537-A898A528-462A-4620-ABA4-D17B298DE4C5Q42274302-1F5EC2A0-58FB-4D63-ADC8-327B2DF02FA7Q42908028-FB89F229-76FB-4C5D-B215-5CFB8D19C530Q43139997-55C8429A-6B1C-492C-8CDE-F8689EF31FC0Q45285746-FCD6E7A1-34E4-46CD-B181-059EFBCB3F12Q45299363-B0C5B35A-79D2-4E86-8557-3E88AB17C2B2Q46626309-6331BE0B-BC50-4F32-8E2D-28770AE87D45Q46639116-A92526DA-C26E-4086-AC8B-81AF1EA54C15Q47148854-36D623B2-4834-47B6-B55B-40E20C386612Q47378538-9A4F7801-629F-497C-8C17-8237361D8F5DQ47607464-915AAE4A-07DF-449B-8A59-05771C5E5186Q47763611-081AD207-7F5D-483E-A7DF-1FC7C9F3D642Q48164114-B5AD6AA8-B54A-4409-8A5E-D3962FB13811Q48313658-C9F5E9B1-DBA1-44E8-85F8-DD2EA304FDD1Q50248094-91B20B7B-E8C2-471E-9005-CEE6A8BF498CQ50965510-4815AB2C-632E-4740-AC02-CFE2805AE5C2Q52991000-DE3DF8A7-7F66-402B-A7D3-6D979C1F2E48
P2860
Late-stage [(18)F]Fluorination: New Solutions to Old Problems
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Late-stage [
@nl
Late-stage [(18)F]Fluorination: New Solutions to Old Problems
@en
type
label
Late-stage [
@nl
Late-stage [(18)F]Fluorination: New Solutions to Old Problems
@en
prefLabel
Late-stage [
@nl
Late-stage [(18)F]Fluorination: New Solutions to Old Problems
@en
P2860
P50
P356
P1433
P1476
Late-stage [18F]Fluorination: New Solutions to Old Problems
@en
P2093
Joseph J Topczewski
Naoko Ichiishi
P2860
P304
P356
10.1039/C4SC02099E
P577
2014-12-01T00:00:00Z