A Translational Systems Pharmacology Model for Aβ Kinetics in Mouse, Monkey, and Human.

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Studying the Progression of Amyloid Pathology and Its Therapy Using Translational Longitudinal Model of Accumulation and Distribution of Amyloid Beta.

P2860

Q42621653-45D11A51-E156-4FBE-AE69-6F932F9380C8

P2860

A Translational Systems Pharmacology Model for Aβ Kinetics in Mouse, Monkey, and Human.

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http://www.wikidata.org/entity/Q42621620

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2017 nî lūn-bûn

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2017年の論文

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@yue

2017年論文

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2017年論文

@zh-hk

2017年論文

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2017年論文

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name

A Translational Systems Pharmacology Model for Aβ Kinetics in Mouse, Monkey, and Human.

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A Translational Systems Pharmacology Model for Aβ Kinetics in Mouse, Monkey, and Human.

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A Translational Systems Pharmacology Model for Aβ Kinetics in Mouse, Monkey, and Human.

@en

A Translational Systems Pharmacology Model for Aβ Kinetics in Mouse, Monkey, and Human.

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A Translational Systems Pharmacology Model for Aβ Kinetics in Mouse, Monkey, and Human.

@en

A Translational Systems Pharmacology Model for Aβ Kinetics in Mouse, Monkey, and Human.

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P1476

A Translational Systems Pharmacology Model for Aβ Kinetics in Mouse, Monkey, and Human.

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P2093

H A Barton

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O Demin

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S Duvvuri

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T Karelina

http://www.w3.org/2001/XMLSchema#string

T Nicholas

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Y Lu

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P2860

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo

Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

Modulators of γ-secretase activity can facilitate the toxic side-effects and pathogenesis of Alzheimer's disease

Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity

Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus.

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

DBSolve Optimum: a software package for kinetic modeling which allows dynamic visualization of simulation results

Has inhibition of Aβ production adequately been tested as therapeutic approach in mild AD? A model-based meta-analysis of γ-secretase inhibitor data.

Systemic catabolism of Alzheimer's Abeta40 and Abeta42.

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666-675

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scholarly article

P356

10.1002/PSP4.12211

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2017-06-01T00:00:00Z

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A Translational Systems Pharmacology Model for Aβ Kinetics in Mouse, Monkey, and Human.

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P2860

P2860

A Translational Systems Pharmacology Model for Aβ Kinetics in Mouse, Monkey, and Human.

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type

label

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P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P577

P698

P932