about
G protein-coupled receptor signalling in astrocytes in health and disease: a focus on metabotropic glutamate receptorsEndogenous G protein-coupled receptor kinase 6 Regulates M3 muscarinic acetylcholine receptor phosphorylation and desensitization in human SH-SY5Y neuroblastoma cellsStructural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptorsClustered coding variants in the glutamate receptor complexes of individuals with schizophrenia and bipolar disorderMechanisms underlying the neuronal calcium sensor-1-evoked enhancement of exocytosis in PC12 cellsThe regulation of M1 muscarinic acetylcholine receptor desensitization by synaptic activity in cultured hippocampal neuronsRegulation of oxytocin receptor responsiveness by G protein-coupled receptor kinase 6 in human myometrial smooth muscleSelective regulation of H1 histamine receptor signaling by G protein-coupled receptor kinase 2 in uterine smooth muscle cells.Long-term channel block is required to inhibit cellular transformation by human ether-à-go-go-related gene (hERG1) potassium channels.FRET-based detection of M1 muscarinic acetylcholine receptor activation by orthosteric and allosteric agonists.[Ca2+]i oscillations in ASM: relationship with persistent airflow obstruction in asthma.Arrestins differentially regulate histamine- and oxytocin-evoked phospholipase C and mitogen-activated protein kinase signalling in myometrial cells.Characterization of an atypical muscarinic cholinoceptor mediating contraction of the guinea-pig isolated uterus.No evidence for altered intracellular calcium-handling in airway smooth muscle cells from human subjects with asthmaSteady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2BStructural aspects of M₃ muscarinic acetylcholine receptor dimer formation and activationArrestins 2 and 3 differentially regulate ETA and P2Y2 receptor-mediated cell signaling and migration in arterial smooth muscle.Defining the roles of arrestin2 and arrestin3 in vasoconstrictor receptor desensitization in hypertension.Increased nicotinamide adenine dinucleotide phosphate oxidase 4 expression mediates intrinsic airway smooth muscle hypercontractility in asthma.Distinct and complementary roles for α and β isoenzymes of PKC in mediating vasoconstrictor responses to acutely elevated glucose"Phenotypic" pharmacology: the influence of cellular environment on G protein-coupled receptor antagonist and inverse agonist pharmacology.An Antibody Biosensor Establishes the Activation of the M1 Muscarinic Acetylcholine Receptor during Learning and Memory.Characterization of anandamide-stimulated cannabinoid receptor signaling in human ULTR myometrial smooth muscle cells.Novel structural and functional insights into M3 muscarinic receptor dimer/oligomer formation.Roles of phosphorylation-dependent and -independent mechanisms in the regulation of M1 muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 in hippocampal neurons.Biosynthetic infochemical communication.Effects of positive allosteric modulators on single-cell oscillatory Ca2+ signaling initiated by the type 5 metabotropic glutamate receptor.Temporal profiling of changes in phosphatidylinositol 4,5-bisphosphate, inositol 1,4,5-trisphosphate and diacylglycerol allows comprehensive analysis of phospholipase C-initiated signalling in single neurons.Regulation of cyclic AMP response-element binding-protein (CREB) by Gq/11-protein-coupled receptors in human SH-SY5Y neuroblastoma cells.Modulation of Gq-protein-coupled inositol trisphosphate and Ca2+ signaling by the membrane potential.HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4.A single point mutation (N514Y) in the human M3 muscarinic acetylcholine receptor reveals differences in the properties of antagonists: evidence for differential inverse agonism.Single cell analysis and temporal profiling of agonist-mediated inositol 1,4,5-trisphosphate, Ca2+, diacylglycerol, and protein kinase C signaling using fluorescent biosensors.Specificity of g protein-coupled receptor kinase 6-mediated phosphorylation and regulation of single-cell m3 muscarinic acetylcholine receptor signaling.Reassessment of the Ca2+ sensing property of a type I metabotropic glutamate receptor by simultaneous measurement of inositol 1,4,5-trisphosphate and Ca2+ in single cells.Pharmacological characterization of type 1alpha metabotropic glutamate receptor-stimulated [35S]-GTPgammaS binding.Principal role of adenylyl cyclase 6 in K⁺ channel regulation and vasodilator signalling in vascular smooth muscle cells.Endothelin signalling in arterial smooth muscle is tightly regulated by G protein-coupled receptor kinase 2.Enhanced purinoceptor-mediated Ca2+ signalling in L-fibroblasts overexpressing type 1 inositol 1,4,5-trisphosphate receptors.Growth inhibition by the muscarinic M(3) acetylcholine receptor: evidence for p21(Cip1/Waf1) involvement in G(1) arrest.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
John Challiss
@ast
John Challiss
@en
John Challiss
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John Challiss
@nl
John Challiss
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type
label
John Challiss
@ast
John Challiss
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John Challiss
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John Challiss
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John Challiss
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altLabel
R A John Challiss
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prefLabel
John Challiss
@ast
John Challiss
@en
John Challiss
@es
John Challiss
@nl
John Challiss
@sl
P106
P1153
57201905353
7005655779
P21
P31
P496
0000-0001-5506-2848