Conserved gating hinge in ligand- and voltage-dependent K+ channels.
about
BK channels: multiple sensors, one activation gateHigh-resolution structure of the open NaK channelStructure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gatingGating of a pH-sensitive K(2P) potassium channel by an electrostatic effect of basic sensor residues on the selectivity filterSeparate gating mechanisms mediate the regulation of K2P potassium channel TASK-2 by intra- and extracellular pHHelical distortion in tryptophan- and lysine-anchored membrane-spanning alpha-helices as a function of hydrophobic mismatch: a solid-state deuterium NMR investigation using the geometric analysis of labeled alanines methodCharacterization and functional restoration of a potassium channel Kir6.2 pore mutation identified in congenital hyperinsulinismGlycine311, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix.Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism.Role of conserved glycines in pH gating of Kir1.1 (ROMK)Molecular characterization of the inositol 1,4,5-trisphosphate receptor pore-forming segment.Transmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K(2P) channels.New roles for a key glycine and its neighboring residue in potassium channel gating.Cysteine scanning and modification reveal major differences between BK channels and Kv channels in the inner pore region.Conservation analysis of residues in the S4-S5 linker and the terminal part of the S5-P-S6 pore modulus in Kv and HCN channels: flexible determinants for the electromechanical coupling.Identification of the Conformational transition pathway in PIP2 Opening Kir Channels.Channel Gating Dependence on Pore Lining Helix Glycine Residues in Skeletal Muscle Ryanodine ReceptorCoupling between the voltage-sensing and pore domains in a voltage-gated potassium channel.Molecular template for a voltage sensor in a novel K+ channel. I. Identification and functional characterization of KvLm, a voltage-gated K+ channel from Listeria monocytogenes.Investigating the putative glycine hinge in Shaker potassium channel.Extrapolating microdomain Ca(2+) dynamics using BK channels as a Ca(2+) sensor.A residue at the cytoplasmic entrance of BK-type channels regulating single-channel opening by its hydrophobicity.Allosteric coupling between proximal C-terminus and selectivity filter is facilitated by the movement of transmembrane segment 4 in TREK-2 channel.End-point targeted molecular dynamics: large-scale conformational changes in potassium channels.Investigations of the contribution of a putative glycine hinge to ryanodine receptor channel gatingDirect analysis of cooperativity in multisubunit allosteric proteins.On the origin of large flexibility of P-glycoprotein in the inward-facing stateMolecular template for a voltage sensor in a novel K+ channel. III. Functional reconstitution of a sensorless pore module from a prokaryotic Kv channelVoltage- and [ATP]-dependent gating of the P2X(2) ATP receptor channel.Molecular mechanisms of BK channel activation.Intersubunit coupling in the pore of BK channels.Dynamic aspects of functional regulation of the ATP receptor channel P2X2.Being flexible: the voltage-controllable activation gate of kv channels.Side chain flexibility and coupling between the S4-S5 linker and the TRP domain in thermo-sensitive TRP channels: Insights from protein modeling.On the simple random-walk models of ion-channel gate dynamics reflecting long-term memory.A Kv channel with an altered activation gate sequence displays both "fast" and "slow" activation kinetics.Molecular Dynamics Simulations of KirBac1.1 Mutants Reveal Global Gating Changes of Kir Channels.Conformational Response of Influenza A M2 Transmembrane Domain to Amantadine Drug Binding at Low pH (pH 5.5).Physicochemical properties of pore residues predict activation gating of Ca V1.2: a correlation mutation analysis.Non-equivalent role of TM2 gating hinges in heteromeric Kir4.1/Kir5.1 potassium channels.
P2860
Q26830341-6D735B75-737E-46D1-A1D8-4AB7FC70BB90Q27653201-8F7A7357-732A-4C37-A816-D775ECF2B91FQ27676659-31EB29D3-04E6-4CF6-9C16-7B89BA073ED5Q28476814-375A96F5-A915-49B7-B836-B86C6E1857E1Q28584821-38B19F55-2914-4A1E-A779-3EEAFC531EFAQ31126703-13EC93A9-EF36-4A79-99ED-B915CBA235B6Q33673386-27022613-E83D-4A6D-AC9B-48965E44A15EQ33814306-5947FC1C-7A71-4FA6-BB70-59A01F6BC6E1Q34409608-22BBAFB6-7498-4B33-900A-83E9E40F6475Q34546935-A4F55534-6D4B-479F-8D4E-8E25D1386A68Q34715202-48316790-7402-403C-B87D-1BAED9C87E38Q34734923-D6EF3E80-4B7A-4C8F-B421-0EA2157AF726Q35052008-A240225C-E367-451A-80DE-F31B3C767445Q35123192-82E81867-8F0F-4151-A49B-64678CB90FFEQ35422054-7E103C96-CC05-4FD3-9E5F-BA73CCE79CB5Q35716412-2B39221D-C4ED-4FA2-B39C-D4FDBC3CA104Q35837216-A086F5D4-D911-4967-90EF-0DDEFA605BC1Q36070158-B716E87E-FA64-4C5F-863C-8122EE756F51Q36295803-85D6C874-76F9-465D-9FA4-2993BD122256Q36493535-70973889-2FBB-455D-828A-6EE651D2B7C1Q36499954-FFFF5E62-643D-4A94-971A-E9B5A4B6A615Q36538181-4F8A4501-13D6-4051-AEB6-C9B41342BBA1Q36583087-F6D3BBFA-2322-4174-91E1-4FCF8623AE2CQ36785203-9DDF02DD-AABE-41BD-83D9-93E19BD81007Q36910107-10D94B97-56B1-478C-BFE0-8279586C5BE5Q36954562-B2E77089-E0D4-46DE-A90B-3B4D2285768FQ36967408-E7162DD4-9FF9-447F-AB49-AE93EBCF1FC0Q36980027-51ED63CC-9E08-4BD7-A2A9-8F802D9CD2AEQ37023269-CA31B2B1-B3D5-47EE-948B-3646279A986CQ37223668-F56037E8-EFF9-4498-8FE0-05C59FFBADADQ37358094-3486A1C4-8FD6-4A3B-A40E-547E7258C080Q37596780-1389120F-44FA-40DA-9E0A-0F87102869EEQ38044898-505BD1D6-AC30-4891-80E4-8EC3F673A434Q39032562-050B1F38-E992-481B-BE95-7C0330BA32F8Q39367774-157013E3-0460-4C8C-8704-E79DA4984AD0Q39995529-26A89F28-98FD-482C-BB74-17ACAFDC4952Q40103040-24BB52F4-ECB6-47EF-B213-F33BE7C83169Q40575932-107E0404-DEFB-4395-A082-28A2BBE610FFQ41645358-AB23DB42-1483-4C00-A10B-29CD7C450CE6Q42046369-67F08017-50EE-4028-B32A-F43E83FA56E3
P2860
Conserved gating hinge in ligand- and voltage-dependent K+ channels.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Conserved gating hinge in ligand- and voltage-dependent K+ channels.
@en
Conserved gating hinge in ligand- and voltage-dependent K+ channels.
@nl
type
label
Conserved gating hinge in ligand- and voltage-dependent K+ channels.
@en
Conserved gating hinge in ligand- and voltage-dependent K+ channels.
@nl
prefLabel
Conserved gating hinge in ligand- and voltage-dependent K+ channels.
@en
Conserved gating hinge in ligand- and voltage-dependent K+ channels.
@nl
P356
P1433
P1476
Conserved gating hinge in ligand- and voltage-dependent K+ channels.
@en
P2093
Elhanan Magidovich
Ofer Yifrach
P304
13242-13247
P356
10.1021/BI048377V
P407
P577
2004-10-01T00:00:00Z