Access and binding of local anesthetics in the closed sodium channel.
about
Exploring volatile general anesthetic binding to a closed membrane-bound bacterial voltage-gated sodium channel via computationBisphenol A binds to the local anesthetic receptor site to block the human cardiac sodium channelStructures of KcsA in Complex with Symmetrical Quaternary Ammonium Compounds Reveal a Hydrophobic Binding SiteStructural Basis for Pharmacology of Voltage-Gated Sodium and Calcium ChannelsA molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channelVoltage-Dependent Inhibition of Glycine Receptor Channels by Niflumic AcidExploring the structure of the voltage-gated Na+ channel by an engineered drug access pathway to the receptor site for local anesthetics.Folding similarity of the outer pore region in prokaryotic and eukaryotic sodium channels revealed by docking of conotoxins GIIIA, PIIIA, and KIIIA in a NavAb-based model of Nav1.4.A homology model of the pore domain of a voltage-gated calcium channel is consistent with available SCAM data.Fluoxetine blocks Nav1.5 channels via a mechanism similar to that of class 1 antiarrhythmics.Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism.Molecular determinants of state-dependent block of voltage-gated sodium channels by pilsicainide.Methylsulfonylnitrobenzoates, a new class of irreversible inhibitors of the interaction of the thyroid hormone receptor and its obligate coactivators that functionally antagonizes thyroid hormone.Identification of new batrachotoxin-sensing residues in segment IIIS6 of the sodium channel.Batrachotoxin, pyrethroids, and BTG 502 share overlapping binding sites on insect sodium channels.Three-dimensional modelling of the voltage-gated sodium ion channel from Anopheles gambiae reveals spatial clustering of evolutionarily conserved acidic residues at the extracellular sites.Energy for wild-type acetylcholine receptor channel gating from different choline derivativesInteraction of local anesthetics with the K (+) channel pore domain: KcsA as a model for drug-dependent tetramer stabilityUsing lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity.Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors.Novel molecular determinants in the pore region of sodium channels regulate local anesthetic binding.Block of human cardiac sodium channels by lacosamide: evidence for slow drug binding along the activation pathway.The sodium channel as a target for local anesthetic drugs.The Receptor Site and Mechanism of Action of Sodium Channel Blocker Insecticides.Molecular Insights into the Local Anesthetic Receptor within Voltage-Gated Sodium Channels Using Hydroxylated Analogs of Mexiletine.Non-classical mechanism of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor channel block by fluoxetine.Effect of previous scorpion bite(s) on the action of intrathecal bupivacaine: A case control studyMechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants.Structural model for dihydropyridine binding to L-type calcium channels.Possible roles of exceptionally conserved residues around the selectivity filters of sodium and calcium channelsStructural model for phenylalkylamine binding to L-type calcium channels.Structural Models of Ligand-Bound Sodium Channels.Aconitum and delphinium diterpenoid alkaloids of local anesthetic activity: comparative QSAR analysis based on GA-MLRA/PLS and optimal descriptors approach.The effects of conformational constraints in the polyamine moiety of philanthotoxins on AMPAR inhibition.Functional Characterization and Comparison of Intercellular Communication in Stem Cell-Derived Cardiomyocytes.Voltage-Gated Sodium Channels as Insecticide Targets.Predicting Structural Details of the Sodium Channel Pore Basing on Animal Toxin Studies
P2860
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P2860
Access and binding of local anesthetics in the closed sodium channel.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Access and binding of local anesthetics in the closed sodium channel.
@en
Access and binding of local anesthetics in the closed sodium channel.
@nl
type
label
Access and binding of local anesthetics in the closed sodium channel.
@en
Access and binding of local anesthetics in the closed sodium channel.
@nl
prefLabel
Access and binding of local anesthetics in the closed sodium channel.
@en
Access and binding of local anesthetics in the closed sodium channel.
@nl
P2093
P356
P1476
Access and binding of local anesthetics in the closed sodium channel.
@en
P2093
Boris S Zhorov
Denis B Tikhonov
Iva Bruhova
P304
P356
10.1124/MOL.108.049759
P577
2008-07-24T00:00:00Z