A state-independent interaction between ligand and a conserved arginine residue in cyclic nucleotide-gated channels reveals a functional polarity of the cyclic nucleotide binding site.
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The pharmacology of cyclic nucleotide-gated channels: emerging from the darknessStructural Basis for the cAMP-dependent Gating in the Human HCN4 ChannelProperties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotideC-Linker of cyclic nucleotide-gated channels controls coupling of ligand binding to channel gatingDifferential regulation by cyclic nucleotides of the CNGA4 and CNGB1b subunits in olfactory cyclic nucleotide-gated channelsAbsence of direct cyclic nucleotide modulation of mEAG1 and hERG1 channels revealed with fluorescence and electrophysiological methodsCprK crystal structures reveal mechanism for transcriptional control of halorespiration.Double electron-electron resonance reveals cAMP-induced conformational change in HCN channels.Family of prokaryote cyclic nucleotide-modulated ion channelsMovement of the C-helix during the gating of cyclic nucleotide-gated channels.Ligand-binding domain subregions contributing to bimodal agonism in cyclic nucleotide-gated channelsGating of HCN channels by cyclic nucleotides: residue contacts that underlie ligand binding, selectivity, and efficacy.Cellular context and multiple channel domains determine cAMP sensitivity of HCN4 channels: ligand-independent relief of autoinhibition in HCN4.Structure and Energetics of Allosteric Regulation of HCN2 Ion Channels by Cyclic Nucleotides.Efficient coupling of ligand binding to channel opening by the binding domain of a modulatory (beta) subunit of the olfactory cyclic nucleotide-gated channel.Quantifying the cooperative subunit action in a multimeric membrane receptorA secondary structural transition in the C-helix promotes gating of cyclic nucleotide-regulated ion channelsVoltage-dependent opening of HCN channels: Facilitation or inhibition by the phytoestrogen, genistein, is determined by the activation status of the cyclic nucleotide gating ring.Structural mechanism for the regulation of HCN ion channels by the accessory protein TRIP8b.Functional analysis of human CNGA3 mutations associated with colour blindness suggests impaired surface expression of channel mutants A3(R427C) and A3(R563C).Energetics of cyclic AMP binding to HCN channel C terminus reveal negative cooperativity.Deciphering the function of the CNGB1b subunit in olfactory CNG channels.State-dependent cAMP binding to functioning HCN channels studied by patch-clamp fluorometry.Activation and desensitization of the olfactory cAMP-gated transduction channel: identification of functional modules.Distinct structural determinants of efficacy and sensitivity in the ligand-binding domain of cyclic nucleotide-gated channels.Action of internal pronase on the f-channel kinetics in the rabbit SA node.Functional roles of loops 3 and 4 in the cyclic nucleotide binding domain of cyclic AMP receptor protein from Escherichia coli.Structural insights into the mechanisms of CNBD channel function.Molecular mechanism of cAMP modulation of HCN pacemaker channels.
P2860
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P2860
A state-independent interaction between ligand and a conserved arginine residue in cyclic nucleotide-gated channels reveals a functional polarity of the cyclic nucleotide binding site.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
A state-independent interactio ...... yclic nucleotide binding site.
@en
A state-independent interactio ...... yclic nucleotide binding site.
@nl
type
label
A state-independent interactio ...... yclic nucleotide binding site.
@en
A state-independent interactio ...... yclic nucleotide binding site.
@nl
prefLabel
A state-independent interactio ...... yclic nucleotide binding site.
@en
A state-independent interactio ...... yclic nucleotide binding site.
@nl
P2093
P2860
P356
P1476
A state-independent interactio ...... yclic nucleotide binding site.
@en
P2093
P2860
P304
P356
10.1074/JBC.273.8.4497
P407
P577
1998-02-01T00:00:00Z