A fast and efficient metal-mediated oxidation of isoniazid and identification of isoniazid-NAD(H) adducts.
about
X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacyNew Insight into the Mechanism of Action of and Resistance to Isoniazid: Interaction of Mycobacterium tuberculosis enoyl-ACP Reductase with INH-NADPIsoniazid-resistance conferring mutations in Mycobacterium tuberculosis KatG: catalase, peroxidase, and INH-NADH adduct formation activitiesA novel metabolite of antituberculosis therapy demonstrates host activation of isoniazid and formation of the isoniazid-NAD+ adduct.Comparative analysis of mycobacterial NADH pyrophosphatase isoforms reveals a novel mechanism for isoniazid and ethionamide inactivationProteome-wide profiling of isoniazid targets in Mycobacterium tuberculosis.Diversity in enoyl-acyl carrier protein reductases.Enoyl acyl carrier protein reductase inhibitors: a patent review (2006 - 2010).Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.In vitro inhibition of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA by isoniazid.Preliminary investigations of the effect of lipophilic analogues of the active metabolite of isoniazid toward bacterial and plasmodial strains.Elucidating the structural basis of diphenyl ether derivatives as highly potent enoyl-ACP reductase inhibitors through molecular dynamics simulations and 3D-QSAR study.Studies on the 4-benzoylpyridine-3-carboxamide entity as a fragment model of the Isoniazid-NAD adduct.1H and 13C NMR characterization of pyridinium-type isoniazid-NAD adducts as possible inhibitors of InhA reductase of Mycobacterium tuberculosis.Ethionamide biomimetic activation and an unprecedented mechanism for its conversion into active and non-active metabolites.Isoniazid metal complex reactivity and insights for a novel anti-tuberculosis drug design.
P2860
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P2860
A fast and efficient metal-mediated oxidation of isoniazid and identification of isoniazid-NAD(H) adducts.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
A fast and efficient metal-med ...... dentification of isoniazid-NAD
@nl
A fast and efficient metal-med ...... n of isoniazid-NAD(H) adducts.
@en
type
label
A fast and efficient metal-med ...... dentification of isoniazid-NAD
@nl
A fast and efficient metal-med ...... n of isoniazid-NAD(H) adducts.
@en
prefLabel
A fast and efficient metal-med ...... dentification of isoniazid-NAD
@nl
A fast and efficient metal-med ...... n of isoniazid-NAD(H) adducts.
@en
P2093
P2860
P1433
P1476
A fast and efficient metal-med ...... n of isoniazid-NAD(H) adducts.
@en
P2093
P2860
P304
P356
10.1002/1439-7633(20011203)2:12<877::AID-CBIC877>3.0.CO;2-V
P577
2001-12-01T00:00:00Z