De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells.
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The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramersNetwork of Cancer Genes (NCG 3.0): integration and analysis of genetic and network properties of cancer genesEpigenetic regulators and their impact on therapy in acute myeloid leukemiaMechanisms of epigenetic regulation of leukemia onset and progressionThe de novo DNA methyltransferase DNMT3A in development and cancerStem cell heterogeneity: implications for aging and regenerative medicineRecurrent DNMT3A mutations in patients with myelodysplastic syndromesDNMT3A and TET2 in the Pre-Leukemic Phase of Hematopoietic DisordersComprehensive methylome map of lineage commitment from haematopoietic progenitorsTen-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in miceLoss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesisSingle cell transcriptomics reveals unanticipated features of early hematopoietic precursorsIdentification of DNA methyltransferase 3a as a T cell receptor-induced regulator of Th1 and Th2 differentiation.2i Maintains a Naive Ground State in ESCs through Two Distinct Epigenetic Mechanisms.Novel impact of the DNMT3A R882H mutation on GSH metabolism in a K562 cell model established by TALENs.Epigenetic modifications in pluripotent and differentiated cells.Differential methylation in CN-AML preferentially targets non-CGI regions and is dictated by DNMT3A mutational status and associated with predominant hypomethylation of HOX genes.Dnmt3a is essential for hematopoietic stem cell differentiation.Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia.DNMT3A in haematological malignancies.GABP controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells.Chromatin regulatory mechanisms in pluripotency.DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cellsThe human melanoma side population displays molecular and functional characteristics of enriched chemoresistance and tumorigenesis.Measuring the aging process in stem cellsDNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis.Stem cell gene SALL4 suppresses transcription through recruitment of DNA methyltransferases.Dnmt3a Regulates Proliferation of Muscle Satellite Cells via p57Kip2.Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis.Genome-wide DNA methylation profiles in hematopoietic stem and progenitor cells reveal overrepresentation of ETS transcription factor binding sitesDnmt3a regulates both proliferation and differentiation of mouse neural stem cellsNetwork biology of tumor stem-like cells identified a regulatory role of CBX5 in lung cancer.Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencingTET proteins and 5-methylcytosine oxidation in hematological cancersMutations in DNA methyltransferase (DNMT3A) observed in acute myeloid leukemia patients disrupt processive methylationDNA methylation and hydroxymethylation in hematologic differentiation and transformation.Epigenetic regulation of hematopoiesis by DNA methylationApc regulates the function of hematopoietic stem cells largely through β-catenin-dependent mechanisms.Concise review: hematopoietic stem cell aging, life span, and transplantation.Cigarette smoking and DNA methylation
P2860
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P2860
De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
De novo DNA methyltransferase ...... , in hematopoietic stem cells.
@en
De novo DNA methyltransferase ...... , in hematopoietic stem cells.
@nl
type
label
De novo DNA methyltransferase ...... , in hematopoietic stem cells.
@en
De novo DNA methyltransferase ...... , in hematopoietic stem cells.
@nl
prefLabel
De novo DNA methyltransferase ...... , in hematopoietic stem cells.
@en
De novo DNA methyltransferase ...... , in hematopoietic stem cells.
@nl
P2093
P2860
P356
P1476
De novo DNA methyltransferase ...... , in hematopoietic stem cells.
@en
P2093
Hiromitsu Nakauchi
Masaki Okano
Yuko Tadokoro
P2860
P304
P356
10.1084/JEM.20060750
P407
P577
2007-04-09T00:00:00Z