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Differential adaptive responses to 1- or 2-day fasting in various mouse tissues revealed by quantitative PCR analysisMurine cystathionine gamma-lyase: complete cDNA and genomic sequences, promoter activity, tissue distribution and developmental expressionCystathionine gamma-Lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury.S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species.The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation.Dual regulation of actin rearrangement through lysophosphatidic acid receptor in neuroblast cell lines: actin depolymerization by Ca(2+)-alpha-actinin and polymerization by rhoHypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway.Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2).Lysophosphatidic acid as a novel cell survival/apoptotic factor.2D DIGE proteomic analysis highlights delayed postnatal repression of α-fetoprotein expression in homocystinuria model mice.The H2S-generating enzymes cystathionine β-synthase and cystathionine γ-lyase play a role in vascular development during normal lung alveolarization.Cystathionine-Gamma-Lyase Gene Deletion Protects Mice against Inflammation and Liver Sieve Injury following Polymicrobial SepsisBlockade of sphingosine 1-phosphate receptor 2 signaling attenuates streptozotocin-induced apoptosis of pancreatic beta-cellsImproved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation.Blockade of Sphingosine 1-Phosphate Receptor 2 Signaling Attenuates High-Fat Diet-Induced Adipocyte Hypertrophy and Systemic Glucose Intolerance in Mice.Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2.Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion.Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3.Hydrogen sulfide-producing cystathionine γ-lyase is critical in the progression of kidney fibrosis.Reactive Sulfur Species-Mediated Activation of the Keap1-Nrf2 Pathway by 1,2-Naphthoquinone through Sulfenic Acids Formation under Oxidative Stress.Pyrvinium pamoate inhibits proliferation of myeloma/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3.Protein phosphorylation involved in the gene expression of the hydrogen sulphide producing enzyme cystathionine γ-lyase in the pancreatic β-cell.Hydrogen sulfide is a novel prosecretory neuromodulator in the Guinea-pig and human colon.Hemizygosity of transsulfuration genes confers increased vulnerability against acetaminophen-induced hepatotoxicity in mice.Role of Cystathionine Gamma-Lyase in Immediate Renal Impairment and Inflammatory Response in Acute Ischemic Kidney Injury.Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis.Anandamide-induced neuroblastoma cell rounding via the CB1 cannabinoid receptors.Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors.Abnormal lipid metabolism in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia.Involvement of reactive persulfides in biological bismethylmercury sulfide formation.Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury.Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia.Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions.Alanine exchanges of polar amino acids in the transmembrane domains of a platelet-activating factor receptor generate both constitutively active and inactive mutants.Agonist-induced sequestration, recycling, and resensitization of platelet-activating factor receptor. Role of cytoplasmic tail phosphorylation in each process.Increased expression of the lysosomal protease cathepsin S in hippocampal microglia following kainate-induced seizures.Dietary deprivation of each essential amino acid induces differential systemic adaptive responses in mice.Hydrogen sulfide inhibits the NLRP3 inflammasome and reduces cytokine production both in vitro and in a mouse model of inflammation.The Capture of Cadmium by Reactive Polysulfides Attenuates Cadmium-Induced Adaptive Responses and Hepatotoxicity.Rapid 2D DIGE Proteomic Analysis of Mouse Liver.
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Isao Ishii
@ast
Isao Ishii
@en
Isao Ishii
@es
Isao Ishii
@nl
Isao Ishii
@sl
type
label
Isao Ishii
@ast
Isao Ishii
@en
Isao Ishii
@es
Isao Ishii
@nl
Isao Ishii
@sl
prefLabel
Isao Ishii
@ast
Isao Ishii
@en
Isao Ishii
@es
Isao Ishii
@nl
Isao Ishii
@sl
P106
P1153
7006829833
P31
P496
0000-0002-5367-205X