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"Back door" opening implied by the crystal structure of a carbamoylated acetylcholinesteraseThree-dimensional structure of a complex of galanthamine (Nivalin) with acetylcholinesterase from Torpedo californica: implications for the design of new anti-Alzheimer drugsStructure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteasesCrystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrierDissecting NGF interactions with TrkA and p75 receptors by structural and functional studies of an anti-NGF neutralizing antibodyProbing Torpedo californica acetylcholinesterase catalytic gorge with two novel bis-functional galanthamine derivativesInsights into the fatty acid chain length specificity of the carboxylesterase PA3859 from Pseudomonas aeruginosa: A combined structural, biochemical and computational studyInsights into subtle conformational differences in the substrate-binding loop of fungal 17β-hydroxysteroid dehydrogenase: a combined structural and kinetic approachKinetics of Torpedo californica acetylcholinesterase inhibition by bisnorcymserine and crystal structure of the complex with its leaving groupMultitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-β aggregation and to exert anticholinesterase and antioxidant effectsThe 2.3 A crystal structure of the catalytic domain of recombinant two-chain human tissue-type plasminogen activatorConformational plasticity of proNGFStructural and biochemical analysis of the Rv0805 cyclic nucleotide phosphodiesterase from Mycobacterium tuberculosisIsolation, characterization, and heterologous expression of a carboxylesterase of Pseudomonas aeruginosa PAO1The Structure of the T190M Mutant of Murine α-Dystroglycan at High Resolution: Insight into the Molecular Basis of a Primary DystroglycanopathyFunctional Characterization of Human ProNGF and NGF Mutants: Identification of NGF P61SR100E as a "Painless" Lead Investigational Candidate for Therapeutic ApplicationsSingle cycle structure-based humanization of an anti-nerve growth factor therapeutic antibodyNeutralization of NGF-TrkA receptor interaction by the novel antagonistic anti-TrkA monoclonal antibody MNAC13: a structural insight.Crystal structure of wild-type chaperonin GroEL.Efficient folding of the FcepsilonRI alpha-chain membrane-proximal domain D2 depends on the presence of the N-terminal domain D1.Direct intracellular selection and biochemical characterization of a recombinant anti-proNGF single chain antibody fragment.Role of metal ions on the activity of Mycobacterium tuberculosis pyrazinamidase.Solution conformation of a pectic acid fragment by 1H-NMR and molecular dynamics.Structural insights into a novel interkingdom signaling circuit by cartography of the ligand-binding sites of the homologous quorum sensing LuxR-family.Conformational Rigidity within Plasticity Promotes Differential Target Recognition of Nerve Growth Factor.Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography.Structural basis for inhibition of 17β-hydroxysteroid dehydrogenases by phytoestrogens: The case of fungal 17β-HSDcl.The conundrum of the high-affinity NGF binding site formation unveiled?A comparative analysis of the structural, functional and biological differences between Mouse and Human Nerve Growth Factor.The kiwifruit emerging pathogen Pseudomonas syringae pv. actinidiae does not produce AHLs but possesses three luxR solos.Studies on synthetic LuxR solo hybrids.Crystallization, X-ray diffraction analysis and phasing of 17beta-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus.Evaluation and computational characterization of the facilitated transport of Glc carbon C-1 oxime reactivators across a blood brain barrier model.Reassessing the melatonin pharmacophore--enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue.Functional and structural study of the dimeric inner membrane protein SbmA.In vitro characterization of Arabidopsis CP12 isoforms reveals common biochemical and molecular properties.Census of solo LuxR genes in prokaryotic genomes.Accurate prediction of the bound conformation of galanthamine in the active site of Torpedo californica acetylcholinesterase using molecular docking.Purification, crystallization and preliminary X-ray analysis of the Fab fragment from MNAC13, a novel antagonistic anti-tyrosine kinase A receptor monoclonal antibody.NADH interactions with WT- and S94A-acyl carrier protein reductase from Mycobacterium tuberculosis: an ab initio study.
P50
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P50
description
hulumtues
@sq
researcher
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wetenschapper
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հետազոտող
@hy
name
Doriano Lamba
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Doriano Lamba
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Doriano Lamba
@de
Doriano Lamba
@en
Doriano Lamba
@es
Doriano Lamba
@fr
Doriano Lamba
@nl
Doriano Lamba
@sl
type
label
Doriano Lamba
@ast
Doriano Lamba
@bar
Doriano Lamba
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Doriano Lamba
@en
Doriano Lamba
@es
Doriano Lamba
@fr
Doriano Lamba
@nl
Doriano Lamba
@sl
prefLabel
Doriano Lamba
@ast
Doriano Lamba
@bar
Doriano Lamba
@de
Doriano Lamba
@en
Doriano Lamba
@es
Doriano Lamba
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Doriano Lamba
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Doriano Lamba
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P1053
B-2961-2011
P106
P1153
7003374970
P21
P31
P3829
P496
0000-0001-6859-7868