about
Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments.Discovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV InhibitorsSimple, potent, and selective pyrrole inhibitors of monoamine oxidase types A and BAn high-throughput in vivo screening system to select H3K4-specific histone demethylase inhibitorsPYRROLO[1,2-b][1,2,5]BENZOTHIADIAZEPINES (PBTDs) induce apoptosis in K562 cells.New arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modeling studies.Discovery of biarylaminoquinazolines as novel tubulin polymerization inhibitorsHigh potency of indolyl aryl sulfone nonnucleoside inhibitors towards drug-resistant human immunodeficiency virus type 1 reverse transcriptase mutants is due to selective targeting of different mechanistic forms of the enzyme.New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancerDesign, synthesis, and biological evaluation of 1-phenylpyrazolo[3,4-e]pyrrolo[3,4-g]indolizine-4,6(1H,5H)-diones as new glycogen synthase kinase-3β inhibitors.Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability.New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer.Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitorsMitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules.Arylsulfone-based HIV-1 non-nucleoside reverse transcriptase inhibitors.New Inhibitors of Indoleamine 2,3-Dioxygenase 1: Molecular Modeling Studies, Synthesis, and Biological Evaluation.Violacein, an indole-derived purple-colored natural pigment produced by Janthinobacterium lividum, inhibits the growth of head and neck carcinoma cell lines both in vitro and in vivo.Pharmacological folding chaperones act as allosteric ligands of Frizzled4.New 1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides inhibit hepatitis C virus replication via suppression of cyclooxygenase-2.New indolylarylsulfones as highly potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors.Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents.Mechanism of interaction of novel indolylarylsulfone derivatives with K103N and Y181I mutant HIV-1 reverse transcriptase in complex with its substrates.New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors.Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies.Indolyl aryl sulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: role of two halogen atoms at the indole ring in developing new analogues with improved antiviral activity.Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies.Chiral Indolylarylsulfone Non-Nucleoside Reverse Transcriptase Inhibitors as New Potent and Broad Spectrum Anti-HIV-1 Agents.New arylthioindoles: potent inhibitors of tubulin polymerization. 2. Structure-activity relationships and molecular modeling studies.Arylthioindoles, potent inhibitors of tubulin polymerization.Imidazole analogues of fluoxetine, a novel class of anti-Candida agents.Simple, short peptide derivatives of a sulfonylindolecarboxamide (L-737,126) active in vitro against HIV-1 wild type and variants carrying non-nucleoside reverse transcriptase inhibitor resistance mutations.Apple can act as anti-aging on yeast cells.Indolylarylsulfones carrying a heterocyclic tail as very potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors.Indole-2-carboxamides as allosteric modulators of the cannabinoid CB₁ receptor.Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: new cyclic substituents at indole-2-carboxamide.Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands.Anti-HIV-1 activity of pyrryl aryl sulfone (PAS) derivatives: synthesis and SAR studies of novel esters and amides at the position 2 of the pyrrole nucleus.p38 MAPK differentially controls NK activating ligands at transcriptional and post-transcriptional level on multiple myeloma cells.Docking and 3-D QSAR studies on indolyl aryl sulfones. Binding mode exploration at the HIV-1 reverse transcriptase non-nucleoside binding site and design of highly active N-(2-hydroxyethyl)carboxamide and N-(2-hydroxyethyl)carbohydrazide derivatives
P50
Q27308091-062F7B74-371F-4F57-88E6-5FFBC3679BC8Q27702516-00F14D80-12C8-422A-A01C-25E3A24D812FQ28180971-D3F56AEB-66B1-4152-B1CF-CBB98FD0924DQ28539276-EBF87FBA-8538-4FB1-893E-1393FBFAA181Q30837349-371FBDEE-40B2-4665-B99D-38BE39FECAF5Q33555754-E8549AD8-5F01-42E9-A1A3-99C8BA767EA3Q33863809-815407C8-9714-4910-82BF-2820918F2AC5Q34123716-067699F4-FBDC-4C16-A207-6E9D1DDB3C18Q34133912-1625D904-843B-41A0-9FE6-1F8A67C5FBD7Q35057450-29234899-E384-44DA-93C5-C54BBAB455F5Q35682298-72BA32A5-99C2-4C83-91E4-A2471DF6DB94Q36004162-77EC2ABD-6748-4F36-8C40-3B174E1E59C0Q36584618-695F1A23-DB32-478C-B526-7F68C699B8F7Q37746123-15F1C005-3C9E-4A01-A7EF-C4A76066A183Q38164839-18664AEC-4BE3-44A1-8B77-EDB944C14B6CQ38743007-95B5A8AD-052B-416C-8B06-F7B8972DBCA2Q38828235-F81DB295-F602-453B-9358-CF66E7752364Q38902274-4C5F7AB6-F8C9-4916-B4B9-456F66AAF79FQ38931340-66354783-6C9D-42E3-97EC-8203283B163CQ39000998-2C9D3677-50D7-489E-9FA9-6B3140A4AE34Q39041318-C397977C-B0A8-4388-AE18-3860D0B36535Q39290873-953B3387-B667-4DCC-A28D-B95E2C2D5E71Q39328586-BB02C297-3F10-44D5-BF21-11E5F7F041EDQ39873922-05925F48-AEB4-4722-AD87-1FB431C58FCEQ39974996-16E1B91A-3114-4F9E-A12E-1A65205A6487Q40084817-D30E76C9-7664-4240-9D6B-5C6921D4BF8FQ40133738-1DC13F96-77EA-422C-B62C-3515E19B80F4Q40154491-1A5C868E-9DA0-4220-87C4-B704E9BDD547Q40322294-9364CE76-CC0B-4DC2-8127-EAA0DFCFB030Q40487677-6917E199-59B5-4E82-9E88-8F1C00756D75Q40532963-B4715AF6-9761-46F9-89BB-73CA6AE0442BQ40538441-83601031-8F9E-4B4E-B5D9-A681D2A10DA7Q41852175-AA8D7CF6-6F03-41FF-8B2F-2653CF2F755EQ42180880-785CE2AF-8AA5-4C71-9D98-D91F3353DF20Q42718275-50007CBF-B5E3-4004-9DB1-3FBC09EA7C25Q42747760-DF8C9A3B-4633-46ED-AA35-D75DE30B0CA8Q42860115-259CE783-3704-487A-A33D-EF60558A5337Q44779040-72969EEA-BAFF-4707-B186-93D86758180AQ45160655-95ABB688-5661-48B2-9D83-4C3404257AAFQ45212833-2D255114-EFC6-4561-B8DA-01B2085CFB05
P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Giuseppe La Regina
@ast
Giuseppe La Regina
@en
Giuseppe La Regina
@es
Giuseppe La Regina
@nl
Giuseppe La Regina
@sl
type
label
Giuseppe La Regina
@ast
Giuseppe La Regina
@en
Giuseppe La Regina
@es
Giuseppe La Regina
@nl
Giuseppe La Regina
@sl
prefLabel
Giuseppe La Regina
@ast
Giuseppe La Regina
@en
Giuseppe La Regina
@es
Giuseppe La Regina
@nl
Giuseppe La Regina
@sl
P1053
I-2161-2012
P106
P1153
6602306518
P21
P31
P3829
P496
0000-0003-3252-1161