Mode shift of the voltage sensors in Shaker K+ channels is caused by energetic coupling to the pore domain
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Voltage gated ion channel function: gating, conduction, and the role of water and protonsRegulation of KCNQ/Kv7 family voltage-gated K+ channels by lipids.Interfacial gating triad is crucial for electromechanical transduction in voltage-activated potassium channels.PIP₂-dependent coupling is prominent in Kv7.1 due to weakened interactions between S4-S5 and S6.Double mutant cycle analysis identified a critical leucine residue in the IIS4S5 linker for the activation of the Ca(V)2.3 calcium channel.Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channelConservation analysis of residues in the S4-S5 linker and the terminal part of the S5-P-S6 pore modulus in Kv and HCN channels: flexible determinants for the electromechanical coupling.Gating transitions in the selectivity filter region of a sodium channel are coupled to the domain IV voltage sensor.Regulation of Voltage-Activated K(+) Channel Gating by Transmembrane β Subunits.Opposite Effects of the S4-S5 Linker and PIP(2) on Voltage-Gated Channel Function: KCNQ1/KCNE1 and Other Channels.Coupling of voltage-sensors to the channel pore: a comparative viewVoltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channelsReinitiation at non-canonical start codons leads to leak expression when incorporating unnatural amino acids.Molecular mechanism for depolarization-induced modulation of Kv channel closure.A limited 4 Å radial displacement of the S4-S5 linker is sufficient for internal gate closing in Kv channels.Intermediate state trapping of a voltage sensorPerspectives on: conformational coupling in ion channels: thermodynamics of electromechanical coupling in voltage-gated ion channels.Intra- and Intersubunit Dynamic Binding in Kv4.2 Channel Closed-State InactivationDynamics of internal pore opening in K(V) channels probed by a fluorescent unnatural amino acid.The pore of voltage-gated potassium ion channels is strained when closed.Clinical heterogeneity associated with KCNA1 mutations include cataplexy and nonataxic presentationsA gating charge interaction required for late slow inactivation of the bacterial sodium channel NavAb.S3-S4 linker length modulates the relaxed state of a voltage-gated potassium channelThe isolated voltage sensing domain of the Shaker potassium channel forms a voltage-gated cation channel.Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel.Biochemical and structural analysis of the hyperpolarization-activated K(+) channel MVPMechanism of electromechanical coupling in voltage-gated potassium channels.PIP2 regulation of KCNQ channels: biophysical and molecular mechanisms for lipid modulation of voltage-dependent gating.Modeling ion channels: past, present, and futureMechanisms of activation of voltage-gated potassium channels.C-terminal modulatory domain controls coupling of voltage-sensing to pore opening in Cav1.3 L-type Ca(2+) channels.Voltage-Dependent Gating: Novel Insights from KCNQ1 Channels.Voltage-clamp Fluorometry in Xenopus Oocytes Using Fluorescent Unnatural Amino Acids.A novel mechanism for fine-tuning open-state stability in a voltage-gated potassium channel.Hysteresis of KcsA potassium channel's activation- deactivation gating is caused by structural changes at the channel's selectivity filter.Sequence of gating charge movement and pore gating in HERG activation and deactivation pathwaysInactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening.Gating mechanism of Kv11.1 (hERG) K+ channels without covalent connection between voltage sensor and pore domains.Stabilization of the Activated hERG Channel Voltage Sensor by Depolarization Involves the S4-S5 Linker.Kv4.2 autism and epilepsy mutation enhances inactivation of closed channels but impairs access to inactivated state after opening.
P2860
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P2860
Mode shift of the voltage sensors in Shaker K+ channels is caused by energetic coupling to the pore domain
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Mode shift of the voltage sens ...... ic coupling to the pore domain
@en
Mode shift of the voltage sens ...... ic coupling to the pore domain
@nl
type
label
Mode shift of the voltage sens ...... ic coupling to the pore domain
@en
Mode shift of the voltage sens ...... ic coupling to the pore domain
@nl
prefLabel
Mode shift of the voltage sens ...... ic coupling to the pore domain
@en
Mode shift of the voltage sens ...... ic coupling to the pore domain
@nl
P2860
P356
P1476
Mode shift of the voltage sens ...... ic coupling to the pore domain
@en
P2093
Georges A Haddad
P2860
P304
P356
10.1085/JGP.201010573
P577
2011-05-01T00:00:00Z