Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist.
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One-pot isomerization-cross metathesis-reduction (ICMR) synthesis of lipophilic tetrapeptidesSynthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics.Conformationally Constrained Peptidomimetics as Inhibitors of the Protein Arginine Methyl Transferases.Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities.Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activitiesTachykinins and their receptors: contributions to physiological control and the mechanisms of disease.The design of multitarget ligands for chronic and neuropathic pain.Neurokinin 1 and opioid receptors: relationships and interactions in nervous system.In vivo antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist-neurokinin 1 receptor antagonist chimeraDesign, Synthesis, and Evaluation of a Neurokinin-1 Receptor-Targeted Near-IR Dye for Fluorescence-Guided Surgery of Neuroendocrine Cancers.Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics.Analgesic Properties of Opioid/NK1 Multitarget Ligands with Distinct in Vitro Profiles in Naive and Chronic Constriction Injury Mice.Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: Effect on Opioid Activity and Biodistribution.From receptor binding kinetics to signal transduction; a missing link in predicting in vivo drug-action.Design, Synthesis and Biological Evaluation of Two Opioid Agonist and Cav 2.2 Blocker Multitarget Ligands.Cooperative use of VCD and XRD for the determination of tetrahydrobenzoisoquinolines absolute configuration: a reliable proof of memory of chirality and retention of configuration in enediyne rearrangements.One-pot Crabbé homologation-radical cascade cyclisation with memory of chirality.Hydrazone Linker as a Useful Tool for Preparing Chimeric Peptide/Nonpeptide Bifunctional Compounds.Efficient one-pot synthesis of amino-benzotriazolodiazocinone scaffolds via catalyst-free tandem Ugi-Huisgen reactions.
P2860
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P2860
Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Design of novel neurokinin 1 r ...... rokinin 1 receptor antagonist.
@en
Design of novel neurokinin 1 r ...... rokinin 1 receptor antagonist.
@nl
type
label
Design of novel neurokinin 1 r ...... rokinin 1 receptor antagonist.
@en
Design of novel neurokinin 1 r ...... rokinin 1 receptor antagonist.
@nl
prefLabel
Design of novel neurokinin 1 r ...... rokinin 1 receptor antagonist.
@en
Design of novel neurokinin 1 r ...... rokinin 1 receptor antagonist.
@nl
P2093
P2860
P356
P1476
Design of novel neurokinin 1 r ...... rokinin 1 receptor antagonist.
@en
P2093
Attila Keresztes
Carole Lemieux
Debby Feytens
Dirk Tourwé
Frank Porreca
Joost Van Duppen
Josephine Lai
Jozef Vanden Broeck
Koen Buysse
P2860
P304
P356
10.1021/JM1016285
P407
P577
2011-03-17T00:00:00Z