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A thermodynamic and kinetic analysis of the folding pathway of an SH3 domain entropically stabilised by a redesigned hydrophobic coreThe high-resolution NMR structure of a single-chain chimeric protein mimicking a SH3-peptide complexCrystallization by capillary counter-diffusion and structure determination of the N114A mutant of the SH3 domain of Abl tyrosine kinase complexed with a high-affinity peptide ligandRole of Interfacial Water Molecules in Proline-rich Ligand Recognition by the Src Homology 3 Domain of AblNovel conformational aspects of the third PDZ domain of the neuronal post-synaptic density-95 protein revealed from two 1.4A X-ray structuresObligatory steps in protein folding and the conformational diversity of the transition stateThermodynamic analysis of alpha-spectrin SH3 and two of its circular permutants with different loop lengths: discerning the reasons for rapid folding in proteinsPost-translational modifications modulate ligand recognition by the third PDZ domain of the MAGUK protein PSD-95The impact of extra-domain structures and post-translational modifications in the folding/misfolding behaviour of the third PDZ domain of MAGUK neuronal protein PSD-95.Understanding the polymorphic behaviour of a mutant of the α-spectrin SH3 domain by means of two 1.1 Å resolution structures.Evaluation of folding co-operativity of a chimeric protein based on the molecular recognition between polyproline ligands and SH3 domains.A miniprotein scaffold used to assemble the polyproline II binding epitope recognized by SH3 domains.Thermodynamic dissection of the binding energetics of proline-rich peptides to the Abl-SH3 domain: implications for rational ligand design.A binding event converted into a folding event.Structural cooperativity in the SH3 domain studied by site-directed mutagenesis and amide hydrogen exchange.pH dependence of the hydrogen exchange in the SH3 domain of alpha-spectrin.The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved.Thermodynamic and kinetic analysis of the SH3 domain of spectrin shows a two-state folding transition.Thermodynamic impact of embedded water molecules in the unfolding of human CD2BP2-GYF domain.Structure of human TSG101 UEV domain.The interconversion between a flexible β-sheet and a fibril β-arrangement constitutes the main conformational event during misfolding of PSD95-PDZ3 domainAlteration of the C-terminal ligand specificity of the erbin PDZ domain by allosteric mutational effects.An error analysis for two-state protein-folding kinetic parameters and phi-values: progress toward precision by exploring pH dependencies on Leffler plots.An oligomeric equilibrium intermediate as the precursory nucleus of globular and fibrillar supramacromolecular assemblies in a PDZ domain.Common features in the unfolding and misfolding of PDZ domains and beyond: the modulatory effect of domain swapping and extra-elements.Thermodynamic characterization of the folding equilibrium of the human Nedd4-WW4 domain: at the frontiers of cooperative folding.The denaturation of circular enterocin AS-48 by urea and guanidinium hydrochloride.Analysis of the thermodynamics of binding of an SH3 domain to proline-rich peptides using a chimeric fusion protein.A thermodynamic study of the third PDZ domain of MAGUK neuronal protein PSD-95 reveals a complex three-state folding behavior.Approaching the thermodynamic view of protein folding through the reproduction of Anfinsen's experiment by undergraduate physical biochemistry students.Towards the improvement in stability of an anti-Aβ single-chain variable fragment, scFv-h3D6, as a way to enhance its therapeutic potential.Understanding the contribution of disulfide bridges to the folding and misfolding of an anti-Aβ scFv.Thermodynamic analysis of the chemotactic protein from Escherichia coli, CheY.A comparative analysis of the folding and misfolding pathways of the third PDZ domain of PSD95 investigated under different pH conditionsKinetic analysis and modelling of the allosteric behaviour of liver and muscle glycogen phosphorylasesStructure of the transition state in the folding process of human procarboxypeptidase A2 activation domainProtein Folding Cooperativity and Thermodynamic Barriers of the Simplest β-Sheet Fold: A Survey of WW DomainsChapter 12. Biocalorimetry: Differential Scanning Calorimetry of Protein SolutionsBinding curves by continuous gradient flow-mix calorimetryAS-48: a circular protein with an extremely stable globular structure
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Jose C Martinez
@ast
Jose C Martinez
@en
Jose C Martinez
@es
Jose C Martinez
@nl
Jose C Martinez
@sl
type
label
Jose C Martinez
@ast
Jose C Martinez
@en
Jose C Martinez
@es
Jose C Martinez
@nl
Jose C Martinez
@sl
prefLabel
Jose C Martinez
@ast
Jose C Martinez
@en
Jose C Martinez
@es
Jose C Martinez
@nl
Jose C Martinez
@sl
P1053
J-8721-2012
P106
P21
P31
P3829
P496
0000-0003-2657-2456