Evidence of abundant purifying selection in humans for recently acquired regulatory functions.
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8.2% of the Human genome is constrained: variation in rates of turnover across functional element classes in the human lineageDynamics of DNA methylation in recent human and great ape evolutionThe case for junk DNAIntegrative annotation of variants from 1092 humans: application to cancer genomicsOn the immortality of television sets: "function" in the human genome according to the evolution-free gospel of ENCODEDefining functional DNA elements in the human genomeIs junk DNA bunk? A critique of ENCODEEnhancers: five essential questionsThe search for cis-regulatory driver mutations in cancer genomesVolatile evolution of long noncoding RNA repertoires: mechanisms and biological implicationsUsing the ENCODE Resource for Functional Annotation of Genetic VariantsComparative genomics as a tool to understand evolution and diseaseEpigenetics, chromatin and genome organization: recent advances from the ENCODE projectLineage-specific genomics: Frequent birth and death in the human genome: The human genome contains many lineage-specific elements created by both sequence and functional turnoverThe persistent contributions of RNA to eukaryotic gen(om)e architecture and cellular functionMany human accelerated regions are developmental enhancersExaptation of transposable elements into novel cis-regulatory elements: is the evidence always strong?Natural Selection and Functional Potentials of Human Noncoding Elements Revealed by Analysis of Next Generation Sequencing DataGenetic and epigenetic variation in the lineage specification of regulatory T cells.Friendship and natural selection.Length and GC content variability of introns among teleostean genomes in the light of the metabolic rate hypothesisMapping Bias Overestimates Reference Allele Frequencies at the HLA Genes in the 1000 Genomes Project Phase I Data.A statistical framework to predict functional non-coding regions in the human genome through integrated analysis of annotation data.Inferring Selective Constraint from Population Genomic Data Suggests Recent Regulatory Turnover in the Human Brain.Laying a solid foundation for Manhattan--'setting the functional basis for the post-GWAS era'.Alternative splicing governs cone cyclic nucleotide-gated (CNG) channel sensitivity to regulation by phosphoinositides.Applications of the 1000 Genomes Project resourcesEvolution of transcription factor binding in metazoans - mechanisms and functional implications.Longevity and plasticity of CFTR provide an argument for noncanonical SNP organization in hominid DNAA method for calculating probabilities of fitness consequences for point mutations across the human genomePartitioning heritability of regulatory and cell-type-specific variants across 11 common diseases.Role of non-coding sequence variants in cancer.Balancing selection on a regulatory region exhibiting ancient variation that predates human-neandertal divergenceTransposable elements are major contributors to the origin, diversification, and regulation of vertebrate long noncoding RNAs.Effects of gene regulatory reprogramming on gene expression in human and mouse developing heartsSelective constraint, background selection, and mutation accumulation variability within and between human populations.Contributions of protein-coding and regulatory change to adaptive molecular evolution in murid rodentsSystematically profiling and annotating long intergenic non-coding RNAs in human embryonic stem cell.In-silico analysis of inflammatory bowel disease (IBD) GWAS loci to novel connections.Approximation to the distribution of fitness effects across functional categories in human segregating polymorphisms.
P2860
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P2860
Evidence of abundant purifying selection in humans for recently acquired regulatory functions.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Evidence of abundant purifying ...... acquired regulatory functions.
@en
Evidence of abundant purifying ...... acquired regulatory functions.
@nl
type
label
Evidence of abundant purifying ...... acquired regulatory functions.
@en
Evidence of abundant purifying ...... acquired regulatory functions.
@nl
prefLabel
Evidence of abundant purifying ...... acquired regulatory functions.
@en
Evidence of abundant purifying ...... acquired regulatory functions.
@nl
P2860
P356
P1433
P1476
Evidence of abundant purifying ...... acquired regulatory functions.
@en
P2860
P304
P356
10.1126/SCIENCE.1225057
P407
P577
2012-09-05T00:00:00Z