Disruption of the Man-6-P targeting pathway in mice impairs osteoclast secretory lysosome biogenesis.
about
Osteopetrorickets due to Snx10 deficiency in mice results from both failed osteoclast activity and loss of gastric acid-dependent calcium absorption.Autophagy proteins regulate the secretory component of osteoclastic bone resorption.Excessive activity of cathepsin K is associated with cartilage defects in a zebrafish model of mucolipidosis II.Monocytes/Macrophages Upregulate the Hyaluronidase HYAL1 and Adapt Its Subcellular Trafficking to Promote Extracellular Residency upon Differentiation into Osteoclasts.Protein kinase C-delta deficiency perturbs bone homeostasis by selective uncoupling of cathepsin K secretion and ruffled border formation in osteoclastsCathepsin-Mediated Alterations in TGFß-Related Signaling Underlie Disrupted Cartilage and Bone Maturation Associated With Impaired Lysosomal Targeting.Membrane trafficking in osteoblasts and osteoclasts: new avenues for understanding and treating skeletal diseasesPLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis.Regulation of lysosome biogenesis and functions in osteoclasts.Decreased bone formation and increased osteoclastogenesis cause bone loss in mucolipidosis II.TGN exit of the cation-independent mannose 6-phosphate receptor does not require acid hydrolase binding.Subcellular Trafficking of Mammalian Lysosomal Proteins: An Extended View.The R740S mutation in the V-ATPase a3 subunit increases lysosomal pH, impairs NFATc1 translocation, and decreases in vitro osteoclastogenesis.Distinctive subdomains in the resorbing surface of osteoclasts.N-acetylglucosamine-1-Phosphate Transferase Suppresses Lysosomal Hydrolases in Dysfunctional Osteoclasts: A Potential Mechanism for Vascular Calcification.Essential Role of the a3 Isoform of V-ATPase in Secretory Lysosome Trafficking via Rab7 Recruitment.Effect of methotrexate upon antigen-induced arthritis of the rabbit temporomandibular joint.Histomorphometry in antigen-induced arthritis of the rabbit temporomandibular joint.
P2860
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P2860
Disruption of the Man-6-P targeting pathway in mice impairs osteoclast secretory lysosome biogenesis.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Disruption of the Man-6-P targ ...... secretory lysosome biogenesis.
@en
Disruption of the Man-6-P targ ...... secretory lysosome biogenesis.
@nl
type
label
Disruption of the Man-6-P targ ...... secretory lysosome biogenesis.
@en
Disruption of the Man-6-P targ ...... secretory lysosome biogenesis.
@nl
prefLabel
Disruption of the Man-6-P targ ...... secretory lysosome biogenesis.
@en
Disruption of the Man-6-P targ ...... secretory lysosome biogenesis.
@nl
P2093
P2860
P50
P1433
P1476
Disruption of the Man-6-P targ ...... secretory lysosome biogenesis.
@en
P2093
Eline van Meel
F Patrick Ross
Haibo Zhao
Marielle Boonen
Stuart Kornfeld
P2860
P304
P356
10.1111/J.1600-0854.2011.01203.X
P577
2011-05-05T00:00:00Z