Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits.
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Autoimmune diseases - connecting risk alleles with molecular traits of the immune system.Making sense of GWAS: using epigenomics and genome engineering to understand the functional relevance of SNPs in non-coding regions of the human genomeTranscriptional enhancers: functional insights and role in human diseaseEnhancer malfunction in cancerHijacked in cancer: the KMT2 (MLL) family of methyltransferases4DGenome: a comprehensive database of chromatin interactions.Constructing 3D interaction maps from 1D epigenomes.Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer TypesRestless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalonGenetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarizationEpigenomic comparison reveals activation of "seed" enhancers during transition from naive to primed pluripotencyMultiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein CholesterolAllele-specific quantitative proteomics unravels molecular mechanisms modulated by cis-regulatory PPARG locus variation.Global view of enhancer-promoter interactome in human cells.Transversions have larger regulatory effects than transitions.Systematic mapping of functional enhancer-promoter connections with CRISPR interference.Effects of Type 1 Diabetes Risk Alleles on Immune Cell Gene ExpressionMassively parallel quantification of the regulatory effects of noncoding genetic variation in a human cohort.Enhancer sequence variants and transcription-factor deregulation synergize to construct pathogenic regulatory circuits in B-cell lymphoma.Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1Models of human core transcriptional regulatory circuitries.Enhancer variants: evaluating functions in common disease.Approaches for establishing the function of regulatory genetic variants involved in disease.Identifying causal regulatory SNPs in ChIP-seq enhancersFine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1.Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.Path from schizophrenia genomics to biology: gene regulation and perturbation in neurons derived from induced pluripotent stem cells and genome editing.Characterisation of genetic variation in ST8SIA2 and its interaction region in NCAM1 in patients with bipolar disorderMultiple functional risk variants in a SMAD7 enhancer implicate a colorectal cancer risk haplotype.Genetics of the dentofacial variation in human malocclusionZNF143 provides sequence specificity to secure chromatin interactions at gene promoters.Multiple functional variants in long-range enhancer elements contribute to the risk of SNP rs965513 in thyroid cancer.Expression quantitative trait locus analysis for translational medicine.Functional FLT1 Genetic Variation is a Prognostic Factor for Recurrence in Stage I-III Non-Small-Cell Lung CancerMotif signatures in stretch enhancers are enriched for disease-associated genetic variants.Enrichment of Genetic Variants for Rheumatoid Arthritis within T-Cell and NK-Cell Enhancer Regions.Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170.Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancerIdentification of novel genetic markers of breast cancer survival.Local Joint Testing Improves Power and Identifies Hidden Heritability in Association Studies.
P2860
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P2860
Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Combinatorial effects of multi ...... sceptibility to common traits.
@en
Combinatorial effects of multi ...... sceptibility to common traits.
@nl
type
label
Combinatorial effects of multi ...... sceptibility to common traits.
@en
Combinatorial effects of multi ...... sceptibility to common traits.
@nl
prefLabel
Combinatorial effects of multi ...... sceptibility to common traits.
@en
Combinatorial effects of multi ...... sceptibility to common traits.
@nl
P2093
P2860
P356
P1433
P1476
Combinatorial effects of multi ...... sceptibility to common traits.
@en
P2093
Alina Saiakhova
Batool Akhtar-Zaidi
Joseph Willis
Lois Myeroff
Olivia Corradin
Peter C Scacheri
Richard Cowper-Sal lari
Sanford Markowitz
P2860
P356
10.1101/GR.164079.113
P577
2013-11-06T00:00:00Z