Conditional knockin of Dnmt3a R878H initiates acute myeloid leukemia with mTOR pathway involvement.

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Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy.Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies.The DNMT3A R882H mutation does not cause dominant negative effects in purified mixed DNMT3A/R882H complexes

P2860

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Conditional knockin of Dnmt3a R878H initiates acute myeloid leukemia with mTOR pathway involvement.

Item

http://www.wikidata.org/entity/Q42776423

description

2017 nî lūn-bûn

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2017年の論文

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2017年論文

@yue

2017年論文

@zh-hant

2017年論文

@zh-hk

2017年論文

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2017年論文

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2017年论文

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2017年论文

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2017年论文

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name

Conditional knockin of Dnmt3a ...... with mTOR pathway involvement.

@en

Conditional knockin of Dnmt3a ...... with mTOR pathway involvement.

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type

Item

label

Conditional knockin of Dnmt3a ...... with mTOR pathway involvement.

@en

Conditional knockin of Dnmt3a ...... with mTOR pathway involvement.

@nl

prefLabel

Conditional knockin of Dnmt3a ...... with mTOR pathway involvement.

@en

Conditional knockin of Dnmt3a ...... with mTOR pathway involvement.

@nl

P1476

Conditional knockin of Dnmt3a ...... with mTOR pathway involvement.

@en

P2093

Jian-Qing Mi

http://www.w3.org/2001/XMLSchema#string

Jie Xu

http://www.w3.org/2001/XMLSchema#string

Jin-Yan Huang

http://www.w3.org/2001/XMLSchema#string

Jing Lu

http://www.w3.org/2001/XMLSchema#string

Li Xia

http://www.w3.org/2001/XMLSchema#string

Pan-Pan Wang

http://www.w3.org/2001/XMLSchema#string

Sai-Juan Chen

http://www.w3.org/2001/XMLSchema#string

Ting Huang

http://www.w3.org/2001/XMLSchema#string

Wei-Na Zhang

http://www.w3.org/2001/XMLSchema#string

Xian-Bin Su

http://www.w3.org/2001/XMLSchema#string

P2860

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs

The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers

DNMT3A Mutations in Acute Myeloid Leukemia

Recurrent DNMT3A mutations in patients with myelodysplastic syndromes

SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.

DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling

mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert)

Dnmt3a is essential for hematopoietic stem cell differentiation.

P304

5237-5242

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P31

scholarly article

P356

10.1073/PNAS.1703476114

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P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

114

http://www.w3.org/2001/XMLSchema#string

P50

Ze-Guang Han

Song-Fang Wu

P577

2017-05-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

28461508

http://www.w3.org/2001/XMLSchema#string

P921

RNA-Seq

P932

5441829

http://www.w3.org/2001/XMLSchema#string

Conditional knockin of Dnmt3a R878H initiates acute myeloid leukemia with mTOR pathway involvement.

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P2860

P2860

Conditional knockin of Dnmt3a R878H initiates acute myeloid leukemia with mTOR pathway involvement.

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P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P921

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P921

P932